ID A6CZY4_9VIBR Unreviewed; 196 AA.
AC A6CZY4;
DT 24-JUL-2007, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2007, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=nicotinate-nucleotide adenylyltransferase {ECO:0000256|ARBA:ARBA00012389};
DE EC=2.7.7.18 {ECO:0000256|ARBA:ARBA00012389};
DE AltName: Full=Deamido-NAD(+) diphosphorylase {ECO:0000256|ARBA:ARBA00033353};
DE AltName: Full=Deamido-NAD(+) pyrophosphorylase {ECO:0000256|ARBA:ARBA00033140};
DE AltName: Full=Nicotinate mononucleotide adenylyltransferase {ECO:0000256|ARBA:ARBA00031253};
GN ORFNames=VSAK1_21699 {ECO:0000313|EMBL:EDL54158.1};
OS Vibrio mediterranei AK1.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=391591 {ECO:0000313|EMBL:EDL54158.1, ECO:0000313|Proteomes:UP000003769};
RN [1] {ECO:0000313|EMBL:EDL54158.1, ECO:0000313|Proteomes:UP000003769}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AK1 {ECO:0000313|EMBL:EDL54158.1,
RC ECO:0000313|Proteomes:UP000003769};
RA Rosenberg E., Ferriera S., Johnson J., Kravitz S., Beeson K., Sutton G.,
RA Rogers Y.-H., Friedman R., Frazier M., Venter J.C.;
RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the reversible adenylation of nicotinate
CC mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
CC {ECO:0000256|ARBA:ARBA00002324}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H(+) + nicotinate beta-D-ribonucleotide = deamido-NAD(+)
CC + diphosphate; Xref=Rhea:RHEA:22860, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57502,
CC ChEBI:CHEBI:58437; EC=2.7.7.18;
CC Evidence={ECO:0000256|ARBA:ARBA00001785};
CC -!- PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+)
CC from nicotinate D-ribonucleotide: step 1/1.
CC {ECO:0000256|ARBA:ARBA00005019}.
CC -!- SIMILARITY: Belongs to the NadD family.
CC {ECO:0000256|ARBA:ARBA00009014}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDL54158.1}.
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DR EMBL; ABCH01000010; EDL54158.1; -; Genomic_DNA.
DR AlphaFoldDB; A6CZY4; -.
DR UniPathway; UPA00253; UER00332.
DR Proteomes; UP000003769; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004515; F:nicotinate-nucleotide adenylyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0009435; P:NAD biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd02165; NMNAT; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR InterPro; IPR004821; Cyt_trans-like.
DR InterPro; IPR005248; NadD/NMNAT.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR PANTHER; PTHR39321; NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE-RELATED; 1.
DR PANTHER; PTHR39321:SF3; PHOSPHOPANTETHEINE ADENYLYLTRANSFERASE; 1.
DR Pfam; PF01467; CTP_transf_like; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Nucleotidyltransferase {ECO:0000313|EMBL:EDL54158.1};
KW Pyridine nucleotide biosynthesis {ECO:0000256|ARBA:ARBA00022642};
KW Transferase {ECO:0000313|EMBL:EDL54158.1}.
FT DOMAIN 32..168
FT /note="Cytidyltransferase-like"
FT /evidence="ECO:0000259|Pfam:PF01467"
SQ SEQUENCE 196 AA; 22230 MW; D85492664B60147F CRC64;
MIPTKIAEKK LQLGSIYAER RFIEIHMTKI AIFGSAFNPP SFGHKSVIQS LNHFDKVLLV
PSISHAWGKS MLDYSIRCQL VDMFISDIGQ ANVERSNIEE SLYEPGTSVT TFAVLEALEK
RYPEAELTFV VGPDNFFSFS KFYKAQDIVE RWSILACPEK VKIRSTTIRY SLSQGLNVDH
LTTLSVAQHL VAHKLY
//
