ID A6D2R9_9VIBR Unreviewed; 456 AA.
AC A6D2R9;
DT 24-JUL-2007, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2007, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=Multidrug resistance protein NorM {ECO:0000256|ARBA:ARBA00013489};
DE AltName: Full=Multidrug-efflux transporter {ECO:0000256|ARBA:ARBA00031636};
DE AltName: Full=Na(+)/drug antiporter {ECO:0000256|ARBA:ARBA00030855};
GN ORFNames=VSAK1_25785 {ECO:0000313|EMBL:EDL53145.1};
OS Vibrio mediterranei AK1.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=391591 {ECO:0000313|EMBL:EDL53145.1, ECO:0000313|Proteomes:UP000003769};
RN [1] {ECO:0000313|EMBL:EDL53145.1, ECO:0000313|Proteomes:UP000003769}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AK1 {ECO:0000313|EMBL:EDL53145.1,
RC ECO:0000313|Proteomes:UP000003769};
RA Rosenberg E., Ferriera S., Johnson J., Kravitz S., Beeson K., Sutton G.,
RA Rogers Y.-H., Friedman R., Frazier M., Venter J.C.;
RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDL53145.1}.
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DR EMBL; ABCH01000021; EDL53145.1; -; Genomic_DNA.
DR RefSeq; WP_006072451.1; NZ_ABCH01000021.1.
DR AlphaFoldDB; A6D2R9; -.
DR GeneID; 64086057; -.
DR Proteomes; UP000003769; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR CDD; cd13131; MATE_NorM_like; 1.
DR InterPro; IPR002528; MATE_fam.
DR InterPro; IPR048279; MdtK-like.
DR NCBIfam; TIGR00797; matE; 1.
DR PANTHER; PTHR43298:SF2; FMN_FAD EXPORTER YEEO-RELATED; 1.
DR PANTHER; PTHR43298; MULTIDRUG RESISTANCE PROTEIN NORM-RELATED; 1.
DR Pfam; PF01554; MatE; 2.
DR PIRSF; PIRSF006603; DinF; 1.
PE 4: Predicted;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 12..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 51..72
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 92..109
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 129..146
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 158..180
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 186..212
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 240..263
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 275..296
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 308..335
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 355..380
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 392..412
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 418..441
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 456 AA; 49469 MW; 5AEF5C82FC132A29 CRC64;
MQRYQTEAKN LIKLASPVLI ASIAQTGMGF VDTIMAGGVS AVDMAAVSIA ASVWLPSILF
GIGLLMALVP VVAQLNGAGK QKQIPYEIHQ GFIMALLISV PIVLVLLQIE TILDLMSVET
IMADKTVGYI YAVIFAVPAF LLFQALRSYT DGMSLTKPAM VIGFIGLLIN IPLNWIFVYG
KFGAPALGGV GCGVATTIVY WIMFFMMLFY AVTTERLKHI ELFKTWHKPE RKAQVRLFKL
GFPIAAAIFF EVSLFAVVSL LVAPLGSLVV ASHQVAMNFS SLVFMIPMSI GAAVSIRVGH
KLGETDTAGA VIACRVGLGV GLGAAIFTAI CTLIFKQQIV HLYTDNVEVV ALAMHLLIFA
AIYQCTDAIQ VVAAGALRGY KDMKAIFNRT FIAYWLIGLP LGYVLGMTDL IIEPMGIVGF
WIGFIAGLSS AAIMLTIRLL WMHRQNDELQ LEYASR
//
