ID A6D6U2_9VIBR Unreviewed; 354 AA.
AC A6D6U2;
DT 24-JUL-2007, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2007, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=HemY protein {ECO:0000313|EMBL:EDL51648.1};
GN ORFNames=VSAK1_12255 {ECO:0000313|EMBL:EDL51648.1};
OS Vibrio mediterranei AK1.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=391591 {ECO:0000313|EMBL:EDL51648.1, ECO:0000313|Proteomes:UP000003769};
RN [1] {ECO:0000313|EMBL:EDL51648.1, ECO:0000313|Proteomes:UP000003769}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AK1 {ECO:0000313|EMBL:EDL51648.1,
RC ECO:0000313|Proteomes:UP000003769};
RA Rosenberg E., Ferriera S., Johnson J., Kravitz S., Beeson K., Sutton G.,
RA Rogers Y.-H., Friedman R., Frazier M., Venter J.C.;
RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in a late step of protoheme IX synthesis.
CC {ECO:0000256|ARBA:ARBA00002962}.
CC -!- PATHWAY: Porphyrin-containing compound metabolism; protoheme
CC biosynthesis. {ECO:0000256|ARBA:ARBA00004744}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDL51648.1}.
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DR EMBL; ABCH01000050; EDL51648.1; -; Genomic_DNA.
DR AlphaFoldDB; A6D6U2; -.
DR UniPathway; UPA00252; -.
DR Proteomes; UP000003769; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042168; P:heme metabolic process; IEA:InterPro.
DR GO; GO:0006779; P:porphyrin-containing compound biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR005254; Heme_biosyn_assoc_TPR_pro.
DR InterPro; IPR010817; HemY_N.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR NCBIfam; TIGR00540; TPR_hemY_coli; 1.
DR Pfam; PF07219; HemY_N; 1.
DR Pfam; PF14559; TPR_19; 1.
DR SMART; SM00028; TPR; 1.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS50005; TPR; 1.
PE 4: Predicted;
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Porphyrin biosynthesis {ECO:0000256|ARBA:ARBA00023244};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 11..93
FT /note="HemY N-terminal"
FT /evidence="ECO:0000259|Pfam:PF07219"
FT REPEAT 288..321
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
SQ SEQUENCE 354 AA; 40453 MW; 541240D58239C219 CRC64;
MSVHSSRVCY CALAGLFLLE YIIKKVLYTS VTTFNYFSVR KMRRSRRYTN EGIVKLLEGD
WKLAEKKVTR WANYHDMPLL CYLVASEAAL GQGDKAKRDH YLALAAKQEN SDLAVQLTRA
KQAVREEEWE VAASTLETLK AEHPNNSIVL SLQKTTYREL GEWQALIDLL PKLHKAKLID
ELEQNELNER AQCGLLEDIA SQQGSEGLIN HWNKLPRKTR QSTHLVGCFS KQLIARKADA
EAFTVIKETL KKQGHEDLYK VLPELNLADT HPVVVLLEDV VKKQPDTPEA QSALAQFYFR
EEKWPEAQRH FERALSLRPD VSDYAYLADT LEKQNLSKAA SEVSRKALTL IESK
//
