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Database: UniProt
Entry: A6FKX6_9RHOB
LinkDB: A6FKX6_9RHOB
Original site: A6FKX6_9RHOB 
ID   A6FKX6_9RHOB            Unreviewed;       473 AA.
AC   A6FKX6;
DT   24-JUL-2007, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2007, sequence version 1.
DT   16-JAN-2019, entry version 78.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS01081161};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=RAZWK3B_02450 {ECO:0000313|EMBL:EDM73044.1};
OS   Roseobacter sp. AzwK-3b.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC   Rhodobacteraceae; Roseobacter.
OX   NCBI_TaxID=351016 {ECO:0000313|EMBL:EDM73044.1, ECO:0000313|Proteomes:UP000004119};
RN   [1] {ECO:0000313|EMBL:EDM73044.1, ECO:0000313|Proteomes:UP000004119}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AzwK-3b {ECO:0000313|EMBL:EDM73044.1,
RC   ECO:0000313|Proteomes:UP000004119};
RA   Francis C., Ferriera S., Johnson J., Kravitz S., Beeson K., Sutton G.,
RA   Rogers Y.-H., Friedman R., Frazier M., Venter J.C.;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756121}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS01082709}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EDM73044.1}.
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DR   EMBL; ABCR01000001; EDM73044.1; -; Genomic_DNA.
DR   RefSeq; WP_007811692.1; NZ_ABCR01000001.1.
DR   ProteinModelPortal; A6FKX6; -.
DR   STRING; 351016.RAZWK3B_02450; -.
DR   EnsemblBacteria; EDM73044; EDM73044; RAZWK3B_02450.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   OrthoDB; 219876at2; -.
DR   Proteomes; UP000004119; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756129};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000004119};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS01082702};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00756116};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS01082706};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756117};
KW   Reference proteome {ECO:0000313|Proteomes:UP000004119}.
FT   DOMAIN      165    295       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      381    450       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     173    180       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
FT   COILED      450    470       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   473 AA;  53070 MW;  29D4B862174E470F CRC64;
     MTQEQWGQLK QDLLKSIGKN NYTNWIEPLE LADVNEGVAT FSVPTSFLGN YVSQNFGDLI
     LYKMNTFAPD IRRVQFRVAA NSAARPAMAS PAGARPDVDG AADAPASAAR SGVTTDAGQP
     QSASDIRLNT APLDERFTFD SFVVGKPNEL AHAAARRVAE GGPVTFNPLF LYGGVGLGKT
     HLMHAIAWEL KQRSPELTVL YLSAEQFMYR FVQALRDRKM MDFKELFRSV DVLMVDDVQF
     IAGKESTQEE FFHTFNALVD QNKQIVISGD RAPGEIANLE DRIKSRLQCG LVVDLHPTDY
     ELRLGILQSK SEHYARQYPD LKLSNGVLEF LAHRISTNVR VLEGALTRLF AFASLVGHEI
     TLELTQDCLA DILRASERKV SVEEIQRQVA DHYNIRLSEM IGPKRLRAFA RPRQVAMYLC
     KQMTSRSLPE IGRRFGGRDH TTVMHGVKRI EELQMQDAQI AEDLEILRRT LEG
//
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