ID MUTS_FLAPJ Reviewed; 866 AA.
AC A6GWN3;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 1.
DT 27-MAR-2024, entry version 88.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=FP0395;
OS Flavobacterium psychrophilum (strain ATCC 49511 / DSM 21280 / CIP 103535 /
OS JIP02/86).
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Flavobacterium.
OX NCBI_TaxID=402612;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 49511 / DSM 21280 / CIP 103535 / JIP02/86;
RX PubMed=17592475; DOI=10.1038/nbt1313;
RA Duchaud E., Boussaha M., Loux V., Bernardet J.-F., Michel C., Kerouault B.,
RA Mondot S., Nicolas P., Bossy R., Caron C., Bessieres P., Gibrat J.-F.,
RA Claverol S., Dumetz F., Le Henaff M., Benmansour A.;
RT "Complete genome sequence of the fish pathogen Flavobacterium
RT psychrophilum.";
RL Nat. Biotechnol. 25:763-769(2007).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR EMBL; AM398681; CAL42506.1; -; Genomic_DNA.
DR RefSeq; WP_011962564.1; NC_009613.3.
DR RefSeq; YP_001295324.1; NC_009613.3.
DR AlphaFoldDB; A6GWN3; -.
DR SMR; A6GWN3; -.
DR STRING; 402612.FP0395; -.
DR EnsemblBacteria; CAL42506; CAL42506; FP0395.
DR GeneID; 66551531; -.
DR KEGG; fps:FP0395; -.
DR PATRIC; fig|402612.5.peg.406; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_3_1_10; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000006394; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..866
FT /note="DNA mismatch repair protein MutS"
FT /id="PRO_0000335154"
FT BINDING 618..625
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ SEQUENCE 866 AA; 97456 MW; 73B74145CCC98BAE CRC64;
MSTKEIKETP LMKQYNEIKR KYPDACLLFR VGDFYETFGD DAVRASKILG ITLTKRGAGS
PTETALAGFP HHSINTYLPK LVKAGLRVAI CDQLEDPKMT KTIVKRGVTE LVTPGVSMND
EVLNSKTNNF LASIYFGKKI IGVSFLDVST GEFLTSEGNE EYIDKLLQNF SPSEILVPKQ
NKGDFKEKFG DNFHAFYLED WVYKEDYATE TLTNHFQTNS LKGFGIEELA SGIIASGAIL
YYLSETQHNK IQHITSIHRI AEDAYVWMDR FTIRNLELYH SYNPNAVTLL DIIDKTLSPM
GGRMLKRWLA LPLKNATIIK SRHEVVAYFK DHQEILQKVQ NQIKQISDLE RLISKVAAGR
ISPREIIYLK ESLDAIIPIK ELALKSPQEA VKVIGDSLHS CDLLREKIKT TLNQEAPVAI
SKGNAIAAGI HPELDELRGI SALGKEYLEG IEKRESEKTG ISSLKISFNN VFGYYIEVRN
THKDKVPTEW IRKQTLVNAE RYITEELKEY ETKILGAEEK IQQIENQLFE QLVSWIATYI
KPVQLNANLI AQLDCLISFT QLAIDNKYVC PQINDSFALD IKNGRHPVIE KQLPIGVPYI
ANDVYLDRDT QQLIMITGPN MSGKSAILRQ TALIVLLAQM GSFVPAESVQ MGIVDKIFTR
VGASDNISMG ESTFMVEMNE TASILNNISD RSLVLLDEIG RGTSTYDGVS IAWAIAEFLH
ENPAQPKTLF ATHYHELNEM TESLPRIQNY NVSVKELKDT VLFIRKLVKG GSAHSFGIHV
AKMAGMPQIV LQKAEKILKK LEKNHSAEAL SGTKGNKDDI QLSIFNLDDP LLEEIKEEIL
NLDINTLTPV EALMKLNEIK RMLSKK
//
