ID A6H1H4_FLAPJ Unreviewed; 754 AA.
AC A6H1H4;
DT 24-JUL-2007, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2007, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN OrderedLocusNames=FP2137 {ECO:0000313|EMBL:CAL44198.1}, FP2147
GN {ECO:0000313|EMBL:CAL44208.1};
OS Flavobacterium psychrophilum (strain ATCC 49511 / DSM 21280 / CIP 103535 /
OS JIP02/86).
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Flavobacterium.
OX NCBI_TaxID=402612 {ECO:0000313|EMBL:CAL44198.1, ECO:0000313|Proteomes:UP000006394};
RN [1] {ECO:0000313|EMBL:CAL44198.1, ECO:0000313|Proteomes:UP000006394}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 49511 / DSM 21280 / CIP 103535 / JIP02/86
RC {ECO:0000313|Proteomes:UP000006394}, and JIP02/86
RC {ECO:0000313|EMBL:CAL44198.1};
RX PubMed=17592475; DOI=10.1038/nbt1313;
RA Duchaud E., Boussaha M., Loux V., Bernardet J.F., Michel C., Kerouault B.,
RA Mondot S., Nicolas P., Bossy R., Caron C., Bessieres P., Gibrat J.F.,
RA Claverol S., Dumetz F., Le Henaff M., Benmansour A.;
RT "Complete genome sequence of the fish pathogen Flavobacterium
RT psychrophilum.";
RL Nat. Biotechnol. 25:763-769(2007).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR EMBL; AM398681; CAL44198.1; -; Genomic_DNA.
DR EMBL; AM398681; CAL44208.1; -; Genomic_DNA.
DR RefSeq; WP_011964235.1; NC_009613.3.
DR RefSeq; YP_001297000.1; NC_009613.3.
DR RefSeq; YP_001297010.1; NC_009613.3.
DR AlphaFoldDB; A6H1H4; -.
DR STRING; 402612.FP2137; -.
DR EnsemblBacteria; CAL44198; CAL44198; FP2137.
DR EnsemblBacteria; CAL44208; CAL44208; FP2147.
DR GeneID; 66551674; -.
DR KEGG; fps:FP2137; -.
DR KEGG; fps:FP2147; -.
DR PATRIC; fig|402612.5.peg.2164; -.
DR eggNOG; COG0286; Bacteria.
DR eggNOG; COG0732; Bacteria.
DR HOGENOM; CLU_021520_0_0_10; -.
DR OrthoDB; 9814572at2; -.
DR Proteomes; UP000006394; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR Gene3D; 3.90.220.20; DNA methylase specificity domains; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR044946; Restrct_endonuc_typeI_TRD_sf.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR42933:SF1; SITE-SPECIFIC DNA-METHYLTRANSFERASE (ADENINE-SPECIFIC); 1.
DR PANTHER; PTHR42933; SLR6095 PROTEIN; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF116734; DNA methylase specificity domain; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:CAL44198.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006394};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:CAL44198.1}.
FT DOMAIN 279..557
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
FT COILED 725..752
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 754 AA; 86232 MW; B1A2D569EC766232 CRC64;
MAKNTKGVSE TVTENIFREF YGSSTFIEKS AIPSELGFQS KKNSSSSKGY PDFLLEEEDY
IIVVEAKATS QNDAIVEVQH YMQKNNVTKD IIGIAVSGQK LDQLKVDYFL KTNDSNNCLN
IQENSSLLTL KNIYNIYWQK RYGESVTTES LIKTLNELNK TFNDNNKVKD TERSLFFSGL
MIALKDNTFR NTYKNIQAPS KEEISTIKIT ILECHNLNNA ILEAITRQLA DKINNLSKGY
SWKDRFSFIK NVDYSLLEYK KIITKIEKNI FKPFQNDEKQ DILGKAYKIF LKRAGKIDNK
NIILTPDHMK SLMVELARLN VNDVVLDTCT GTGGFLMEAM EVLIKKANNN ETLIKNIKEN
QLIGFEVDSV LFALACSNMF LHGDGRTNLL FRSSLLDDKN ENIINNKDKD LLNYINSLKP
TKCIINPPYE TNNSIKFTLQ ALKYLEQNGK LVIIMPTPTL TQNQNGITAD ILKIAKLDFV
IKMPYNLFAE QKRTVNTSVF GFTKTPHNQN DEVLFYNLEE DGFVSIQHKG RVDKFNKWED
IRSNIVDSIF NSKEAKGISE KKKIYKDDIL NCAGIQKNIS SNSTLLKIEE LFNIEDGTLA
SDNSEEGEFD FITGAEEWKK HSEYKYDKEA IVYVVSAGGS LGRSHYANGK FIASNLCIVL
TPKNQEKYPI NLQFYNTYLN NLRKKIVSDL ADGTSKLTIG KTLFKQYYID YIEKDIQDEF
VKNHITKYTE KVNELKKLVQ KAETNINNKL SELI
//
