ID   A6H1T3_FLAPJ            Unreviewed;       807 AA.
AC   A6H1T3;
DT   24-JUL-2007, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2007, sequence version 1.
DT   27-MAR-2024, entry version 75.
DE   SubName: Full=Efflux transporter, RND superfamily {ECO:0000313|EMBL:CAL44307.1};
GN   OrderedLocusNames=FP2251 {ECO:0000313|EMBL:CAL44307.1};
OS   Flavobacterium psychrophilum (strain ATCC 49511 / DSM 21280 / CIP 103535 /
OS   JIP02/86).
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Flavobacterium.
OX   NCBI_TaxID=402612 {ECO:0000313|EMBL:CAL44307.1, ECO:0000313|Proteomes:UP000006394};
RN   [1] {ECO:0000313|EMBL:CAL44307.1, ECO:0000313|Proteomes:UP000006394}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49511 / DSM 21280 / CIP 103535 / JIP02/86
RC   {ECO:0000313|Proteomes:UP000006394};
RX   PubMed=17592475; DOI=10.1038/nbt1313;
RA   Duchaud E., Boussaha M., Loux V., Bernardet J.F., Michel C., Kerouault B.,
RA   Mondot S., Nicolas P., Bossy R., Caron C., Bessieres P., Gibrat J.F.,
RA   Claverol S., Dumetz F., Le Henaff M., Benmansour A.;
RT   "Complete genome sequence of the fish pathogen Flavobacterium
RT   psychrophilum.";
RL   Nat. Biotechnol. 25:763-769(2007).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; AM398681; CAL44307.1; -; Genomic_DNA.
DR   RefSeq; WP_011964341.1; NC_009613.3.
DR   RefSeq; YP_001297108.1; NC_009613.3.
DR   AlphaFoldDB; A6H1T3; -.
DR   STRING; 402612.FP2251; -.
DR   EnsemblBacteria; CAL44307; CAL44307; FP2251.
DR   GeneID; 66553355; -.
DR   KEGG; fps:FP2251; -.
DR   PATRIC; fig|402612.5.peg.2302; -.
DR   eggNOG; COG1033; Bacteria.
DR   HOGENOM; CLU_008861_1_0_10; -.
DR   OrthoDB; 9805018at2; -.
DR   Proteomes; UP000006394; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR001036; Acrflvin-R.
DR   InterPro; IPR004869; MMPL_dom.
DR   InterPro; IPR000731; SSD.
DR   PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR   PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR   Pfam; PF03176; MMPL; 2.
DR   PRINTS; PR00702; ACRIFLAVINRP.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   PROSITE; PS50156; SSD; 2.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006394};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        21..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        230..249
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        256..276
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        282..303
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        323..346
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        358..382
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        414..432
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        620..639
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        646..668
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        715..739
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        745..771
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          256..381
FT                   /note="SSD"
FT                   /evidence="ECO:0000259|PROSITE:PS50156"
FT   DOMAIN          644..772
FT                   /note="SSD"
FT                   /evidence="ECO:0000259|PROSITE:PS50156"
SQ   SEQUENCE   807 AA;  91256 MW;  A9D50E1B1D4D324C CRC64;
     MKKMLNIGFW AFVARVILRN RIVFLSGIVL ITILFSMQWK NIKFTQTEAN LIPFDDQINV
     DYRSFLKNFG EEGNLVVIAT KDPKLFTPKV YKAWNNLMAT IQSHKEVDLV ISISNLKKLV
     KNDSLEKFEL RPLIDTNKTQ NQAYLSQIKS DLLNKLPFYE GLLFNKKSGA IRSAIYLDKK
     IINTKARKDF VLNQLIPEIE SFEKEAGVDL RTSGMPYIRT LNAKTILDEI GLFIGAALLI
     TGLIFFFFFR SFRATLISLV IVIIGVMWSF GLLGLLGYEI TVLTALVPTL VIVIGIPNCI
     FLINKYHQEY QVHGNKAKSL QRVITKTGTA TLMTNLTTAL GFATFIVTNN VLLTEFGVVT
     SINIIALYLL CLFIIPIFFS YIPAPIPRHL GHLEREYLTS FMGWILRTVK YNRIGVYITS
     ILLLVLGIIG IYEIRISGSI IEDMPKRTAF FDDIRFFEKE FDGVMPLEIM IDTKRKKGVM
     KLSMLKRMEE LEETIQEIPE LAKPLSIVNL VKYSKQAYYN GNPEYYELPT QQEQAFILSY
     AKKATQNSKE NLMKSYVDST GQFARITTFI KDENGEKMNA IEAQIRAKAN KLFPSPQYNV
     IITGKALVFQ KGTQYLLDNL LSSLAFAFLI TSLLVLIMFR SVKMVIVSLI PNLLPLILTA
     GLMGFLGIPL KPSTILVFGI AYGLSVDDTL RFLAQYRLEL ARNDWKIKKS VIATFNDAGI
     SMFYTSIVLF FGFSVFMLSS FGGTVALGGL VAITLFFGML SNLVLLPALV LSLNKTLSNE
     QEFIEPTIDI LERTDAEVDA MENKNKN
//