ID A6H7C1_BOVIN Unreviewed; 287 AA.
AC A6H7C1;
DT 24-JUL-2007, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2007, sequence version 1.
DT 27-MAR-2024, entry version 114.
DE RecName: Full=Mortality factor 4-like protein 2 {ECO:0000256|ARBA:ARBA00013933};
GN Name=MORF4L2 {ECO:0000313|EMBL:AAI46191.1,
GN ECO:0000313|Ensembl:ENSBTAP00000001731.3,
GN ECO:0000313|VGNC:VGNC:31557};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|EMBL:AAI46191.1};
RN [1] {ECO:0000313|EMBL:AAI46191.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=L1 Hereford {ECO:0000313|EMBL:AAI46191.1};
RC TISSUE=Fetal skin {ECO:0000313|EMBL:AAI46191.1};
RA Moore S., Alexander L., Brownstein M., Guan L., Lobo S., Meng Y.,
RA Tanaguchi M., Wang Z., Yu J., Prange C., Schreiber K., Shenmen C.,
RA Wagner L., Bala M., Barbazuk S., Barber S., Babakaiff R., Beland J.,
RA Chun E., Del Rio L., Gibson S., Hanson R., Kirkpatrick R., Liu J.,
RA Matsuo C., Mayo M., Santos R.R., Stott J., Tsai M., Wong D., Siddiqui A.,
RA Holt R., Jones S.J., Marra M.A.;
RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000001731.3, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000001731.3,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSBTAP00000001731.3}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000001731.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of the NuA4 histone acetyltransferase complex which
CC is involved in transcriptional activation of select genes principally
CC by acetylation of nucleosomal histone H4 and H2A. This modification may
CC both alter nucleosome - DNA interactions and promote interaction of the
CC modified histones with other proteins which positively regulate
CC transcription. This complex may be required for the activation of
CC transcriptional programs associated with oncogene and proto-oncogene
CC mediated growth induction, tumor suppressor mediated growth arrest and
CC replicative senescence, apoptosis, and DNA repair. The NuA4 complex
CC ATPase and helicase activities seem to be, at least in part,
CC contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4
CC may also play a direct role in DNA repair when directly recruited to
CC sites of DNA damage. Also a component of the MSIN3A complex which acts
CC to repress transcription by deacetylation of nucleosomal histones.
CC {ECO:0000256|ARBA:ARBA00034084}.
CC -!- SUBUNIT: Component of the NuA4 histone acetyltransferase complex which
CC contains the catalytic subunit KAT5/TIP60 and the subunits EP400,
CC TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2,
CC ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP,
CC YEATS4/GAS41 and VPS72/YL1. The NuA4 complex interacts with MYC and the
CC adenovirus E1A protein. MORF4L1 may also participate in the formation
CC of NuA4 related complexes which lack the KAT5/TIP60 catalytic subunit,
CC but which include the SWI/SNF related protein SRCAP. Component of the
CC MSIN3A histone deacetylase complex, which includes SIN3A, HDAC2,
CC ARID4B, MORF4L1, RBBP4/RbAp48, and RBBP7/RbAp46. Interacts with MRFAP1
CC and RB1. May also interact with one or more as yet undefined members of
CC the TLE (transducin-like enhancer of split) family of transcriptional
CC repressors. {ECO:0000256|ARBA:ARBA00025930}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; BC146190; AAI46191.1; -; mRNA.
DR RefSeq; NP_001092554.1; NM_001099084.1.
DR RefSeq; XP_005227905.1; XM_005227848.3.
DR RefSeq; XP_005227906.1; XM_005227849.3.
DR RefSeq; XP_005227908.1; XM_005227851.2.
DR RefSeq; XP_005227909.1; XM_005227852.3.
DR RefSeq; XP_005227911.1; XM_005227854.3.
DR STRING; 9913.ENSBTAP00000001731; -.
DR PaxDb; 9913-ENSBTAP00000001731; -.
DR Ensembl; ENSBTAT00000001731.4; ENSBTAP00000001731.3; ENSBTAG00000001311.4.
DR GeneID; 538442; -.
DR KEGG; bta:538442; -.
DR CTD; 9643; -.
DR VEuPathDB; HostDB:ENSBTAG00000001311; -.
DR VGNC; VGNC:31557; MORF4L2.
DR eggNOG; KOG3001; Eukaryota.
DR GeneTree; ENSGT00950000182965; -.
DR HOGENOM; CLU_039566_4_0_1; -.
DR OMA; PTRGNMQ; -.
DR OrthoDB; 2878816at2759; -.
DR TreeFam; TF323400; -.
DR Proteomes; UP000009136; Chromosome X.
DR Bgee; ENSBTAG00000001311; Expressed in adenohypophysis and 105 other cell types or tissues.
DR GO; GO:0035267; C:NuA4 histone acetyltransferase complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 1.10.274.30; MRG domain; 1.
DR InterPro; IPR008676; MRG.
DR InterPro; IPR038217; MRG_C_sf.
DR InterPro; IPR026541; MRG_dom.
DR PANTHER; PTHR10880; MORTALITY FACTOR 4-LIKE PROTEIN; 1.
DR PANTHER; PTHR10880:SF25; MORTALITY FACTOR 4-LIKE PROTEIN 2; 1.
DR Pfam; PF05712; MRG; 1.
DR PROSITE; PS51640; MRG; 1.
PE 2: Evidence at transcript level;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 100..276
FT /note="MRG"
FT /evidence="ECO:0000259|Pfam:PF05712"
FT REGION 1..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..26
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 30..45
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 96..112
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 287 AA; 32252 MW; E03470932E3F75F9 CRC64;
MSSRKQGSQT RGHQSAEEDN FKKPTRSNMQ RSKMRGSSGK KTAGPQQKNL EAALPGRWGG
RSAENPPSGS VRKTRRNKQK TPGNGDGGST SEAPQPPRKK RARADPTVES EDAFKNRMEV
KVKIPEELKP WLVEDWDLVT RQKQLFQLPA KKNVDTILEE YANCKRSQGN VDNKEYAVNE
VVGGIKEYFN VMLGTQLLYK FERPQYAEIL LAHPDAPMSQ VYGAPHLLRL FVRIGAMLAY
TPLDEKSLAL LLGYLHDFLK YLAKNAASLF TASDYKVASA EYHRKAL
//
