ID A6LAJ3_PARD8 Unreviewed; 780 AA.
AC A6LAJ3;
DT 24-JUL-2007, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2007, sequence version 1.
DT 27-MAR-2024, entry version 93.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN OrderedLocusNames=BDI_0939 {ECO:0000313|EMBL:ABR42707.1};
OS Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / CIP 104284 / JCM
OS 5825 / NCTC 11152).
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Tannerellaceae;
OC Parabacteroides.
OX NCBI_TaxID=435591 {ECO:0000313|EMBL:ABR42707.1, ECO:0000313|Proteomes:UP000000566};
RN [1] {ECO:0000313|EMBL:ABR42707.1, ECO:0000313|Proteomes:UP000000566}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8503 / DSM 20701 / CIP 104284 / JCM 5825 / NCTC 11152
RC {ECO:0000313|Proteomes:UP000000566};
RX PubMed=17579514; DOI=10.1371/journal.pbio.0050156;
RA Xu J., Mahowald M.A., Ley R.E., Lozupone C.A., Hamady M., Martens E.C.,
RA Henrissat B., Coutinho P.M., Minx P., Latreille P., Cordum H.,
RA Van Brunt A., Kim K., Fulton R.S., Fulton L.A., Clifton S.W., Wilson R.K.,
RA Knight R.D., Gordon J.I.;
RT "Evolution of symbiotic bacteria in the distal human intestine.";
RL PLoS Biol. 5:1574-1586(2007).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP000140; ABR42707.1; -; Genomic_DNA.
DR RefSeq; WP_011966254.1; NC_009615.1.
DR AlphaFoldDB; A6LAJ3; -.
DR STRING; 435591.BDI_0939; -.
DR PaxDb; 435591-BDI_0939; -.
DR KEGG; pdi:BDI_0939; -.
DR PATRIC; fig|435591.13.peg.920; -.
DR eggNOG; COG0210; Bacteria.
DR HOGENOM; CLU_004585_5_2_10; -.
DR BioCyc; PDIS435591:G1G5A-972-MONOMER; -.
DR Proteomes; UP000000566; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF21196; PcrA_UvrD_tudor; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000000566}.
FT DOMAIN 8..293
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 294..577
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 29..36
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 780 AA; 88327 MW; 10EED10E7DED443C CRC64;
MNVEEYLNQL NESQREAVVY NEGPSLVVAG AGSGKTRVLT YKIAYLLQLG LPPYSILALT
FTNKAAREMK ERIAAITGDQ TARRLWMGTF HSIFSRILRN EAEHIGYPSN FTIYDATDSK
SLLKSIIKEM QLDDKVYRLG MVQSRISNAK NSLITYTAYE QNKELVESDM NAKVPLLREI
YKRYQSRCLQ AGAMDFDDLL LQTNILFRDH PAVLEKYRNF FRYVLVDEYQ DTNFAQHLIV
QRLCERHGHI CVVGDDAQSI YSFRGANIDN ILQFKNLYTG CRIFKLERNY RSTQNIVNAA
NSLIDKNTRQ IPKTVYSEKE AGNKVSVFTS YSDYEEGYTV AARINEMHGI LGKFSYADFA
ILYRTNAQSR ILEEALRKRG IPYKIYGGLS FYQRKEIKDV ISYFRLIVNP HDEEALKRII
NYPTRGIGDT TVGKLVGAAT EYGVSLWTVL QAPLEYSLPI NNGTAKKLSD FRSLIEVFIE
ENKKLSAEEL ATLVVKRSGI VSDLFQDRSV EGVSKQENLQ ELLKGIAEFC EIRREEGMEQ
VAMSDFLAEV SLLTDQDNDK EENSDKVTMM TVHAAKGLEF TNVFVVGLEE DLFPSSLSKD
NPRAVEEERR LFYVAITRAE QNCVLSYAKS RYRNGKTDMC TPSRFLKDID AKYLDMPSDA
GASDAFASAR ERYGRPAFAS PFRQPRAVED DFVSPVKQAA QRQGHLTKLK NTMESSFSAA
PATDLSGLHV GSKVRHDRFG EGEIVSIEGE GGNAKATVAF DHFGQKQLLL KFAKLTMLND
//
