ID   A6LDZ6_PARD8            Unreviewed;       513 AA.
AC   A6LDZ6;
DT   24-JUL-2007, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2007, sequence version 1.
DT   27-MAR-2024, entry version 84.
DE   SubName: Full=Glycoside hydrolase family 43, candidate beta-glycosidase {ECO:0000313|EMBL:ABR43910.1};
GN   OrderedLocusNames=BDI_2179 {ECO:0000313|EMBL:ABR43910.1};
OS   Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / CIP 104284 / JCM
OS   5825 / NCTC 11152).
OC   Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Tannerellaceae;
OC   Parabacteroides.
OX   NCBI_TaxID=435591 {ECO:0000313|EMBL:ABR43910.1, ECO:0000313|Proteomes:UP000000566};
RN   [1] {ECO:0000313|EMBL:ABR43910.1, ECO:0000313|Proteomes:UP000000566}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8503 / DSM 20701 / CIP 104284 / JCM 5825 / NCTC 11152
RC   {ECO:0000313|Proteomes:UP000000566};
RX   PubMed=17579514; DOI=10.1371/journal.pbio.0050156;
RA   Xu J., Mahowald M.A., Ley R.E., Lozupone C.A., Hamady M., Martens E.C.,
RA   Henrissat B., Coutinho P.M., Minx P., Latreille P., Cordum H.,
RA   Van Brunt A., Kim K., Fulton R.S., Fulton L.A., Clifton S.W., Wilson R.K.,
RA   Knight R.D., Gordon J.I.;
RT   "Evolution of symbiotic bacteria in the distal human intestine.";
RL   PLoS Biol. 5:1574-1586(2007).
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 43 family.
CC       {ECO:0000256|ARBA:ARBA00009865, ECO:0000256|RuleBase:RU361187}.
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DR   EMBL; CP000140; ABR43910.1; -; Genomic_DNA.
DR   RefSeq; WP_011966744.1; NC_009615.1.
DR   AlphaFoldDB; A6LDZ6; -.
DR   STRING; 435591.BDI_2179; -.
DR   CAZy; GH43; Glycoside Hydrolase Family 43.
DR   PaxDb; 435591-BDI_2179; -.
DR   KEGG; pdi:BDI_2179; -.
DR   PATRIC; fig|435591.13.peg.2162; -.
DR   eggNOG; COG3507; Bacteria.
DR   HOGENOM; CLU_543697_0_0_10; -.
DR   BioCyc; PDIS435591:G1G5A-2237-MONOMER; -.
DR   Proteomes; UP000000566; Chromosome.
DR   GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd08999; GH43_ABN-like; 1.
DR   Gene3D; 2.60.120.200; -; 1.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR041542; GH43_C2.
DR   InterPro; IPR006710; Glyco_hydro_43.
DR   InterPro; IPR023296; Glyco_hydro_beta-prop_sf.
DR   PANTHER; PTHR42812; BETA-XYLOSIDASE; 1.
DR   PANTHER; PTHR42812:SF5; ENDO-ARABINASE; 1.
DR   Pfam; PF17851; GH43_C2; 1.
DR   Pfam; PF04616; Glyco_hydro_43; 1.
DR   SUPFAM; SSF75005; Arabinanase/levansucrase/invertase; 1.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361187};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361187};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000566};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..513
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5002698774"
FT   DOMAIN          330..472
FT                   /note="Beta-xylosidase C-terminal Concanavalin A-like"
FT                   /evidence="ECO:0000259|Pfam:PF17851"
FT   ACT_SITE        36
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR606710-1"
FT   ACT_SITE        198
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR606710-1"
FT   SITE            143
FT                   /note="Important for catalytic activity, responsible for
FT                   pKa modulation of the active site Glu and correct
FT                   orientation of both the proton donor and substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR606710-2"
SQ   SEQUENCE   513 AA;  57829 MW;  55E3DA25661386FE CRC64;
     MRKIFTLFFC AASLATGLAQ QESYFTNPVI HGDVADPSII RIDQTYYITG TSSEWAPYYP
     VFTSTDLVNW QQTGHVFDEK PEWTKSSFWA PEWYQHKGKV YVYYTARKQS DNISCIGVAV
     ADSPTGKFKD HGPVVEFGKE AIDAFILEDK GKLYISWKAY GLDNQPIELL ACKLTDDGLR
     LDGKPFSLLR DDERQGMEGQ HWFKKDGYYY IIYSVRGCCG PQSDYAVSVA RSKKLEGPYE
     KYLGNPILHG SKEVLSIGHG TITTTPDGRM YYLCHAYQPG SGFYQGRQPY LQEVRMGEDH
     WPHFVTGEYA SRTQPMPFAE SAQVPVFDFS DDFTGATLRP EWSWNYPYTD VKTEIKNGKL
     SLSGTPKPGV KTGAALCLRP TSPNYTLETA IVNRNDSWKG ITMYGDANNL ITCGCAGDRL
     ILKYILEGKE HQLADLPLPA SPLYLQMKVT DGTHSTFYWS KDGQAWNEIV GEALSAKETR
     SLIQWDRISR PGLYQEGDPT APAVYAYCLL KNE
//