ID A6LGD0_PARD8 Unreviewed; 458 AA.
AC A6LGD0;
DT 24-JUL-2007, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2007, sequence version 1.
DT 27-MAR-2024, entry version 83.
DE RecName: Full=Multidrug export protein MepA {ECO:0000256|ARBA:ARBA00022106};
GN OrderedLocusNames=BDI_3037 {ECO:0000313|EMBL:ABR44744.1};
OS Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / CIP 104284 / JCM
OS 5825 / NCTC 11152).
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Tannerellaceae;
OC Parabacteroides.
OX NCBI_TaxID=435591 {ECO:0000313|EMBL:ABR44744.1, ECO:0000313|Proteomes:UP000000566};
RN [1] {ECO:0000313|EMBL:ABR44744.1, ECO:0000313|Proteomes:UP000000566}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8503 / DSM 20701 / CIP 104284 / JCM 5825 / NCTC 11152
RC {ECO:0000313|Proteomes:UP000000566};
RX PubMed=17579514; DOI=10.1371/journal.pbio.0050156;
RA Xu J., Mahowald M.A., Ley R.E., Lozupone C.A., Hamady M., Martens E.C.,
RA Henrissat B., Coutinho P.M., Minx P., Latreille P., Cordum H.,
RA Van Brunt A., Kim K., Fulton R.S., Fulton L.A., Clifton S.W., Wilson R.K.,
RA Knight R.D., Gordon J.I.;
RT "Evolution of symbiotic bacteria in the distal human intestine.";
RL PLoS Biol. 5:1574-1586(2007).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC 2.A.66.1) family. MepA subfamily. {ECO:0000256|ARBA:ARBA00008417}.
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DR EMBL; CP000140; ABR44744.1; -; Genomic_DNA.
DR RefSeq; WP_011967114.1; NC_009615.1.
DR AlphaFoldDB; A6LGD0; -.
DR PaxDb; 435591-BDI_3037; -.
DR KEGG; pdi:BDI_3037; -.
DR PATRIC; fig|435591.13.peg.2998; -.
DR eggNOG; COG0534; Bacteria.
DR HOGENOM; CLU_012893_0_0_10; -.
DR BioCyc; PDIS435591:G1G5A-3113-MONOMER; -.
DR Proteomes; UP000000566; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR CDD; cd13143; MATE_MepA_like; 1.
DR InterPro; IPR002528; MATE_fam.
DR InterPro; IPR045070; MATE_MepA-like.
DR InterPro; IPR048279; MdtK-like.
DR NCBIfam; TIGR00797; matE; 1.
DR PANTHER; PTHR43823:SF3; MULTIDRUG EXPORT PROTEIN MEPA; 1.
DR PANTHER; PTHR43823; SPORULATION PROTEIN YKVU; 1.
DR Pfam; PF01554; MatE; 2.
DR PIRSF; PIRSF006603; DinF; 1.
PE 3: Inferred from homology;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000566};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 21..43
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 63..86
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 98..120
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 140..161
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 168..192
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 198..219
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 239..263
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 283..307
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 319..340
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 360..378
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 390..413
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 419..440
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 458 AA; 50053 MW; EF85F0E28F0D7812 CRC64;
MKNKYEARLG TERMLPLVFK MALPAVAAQF VNLLYNIVDR IYIGHIPEIG TNALAGIGVT
TSIVILISSF SAIVGAGGSP LAAIALGQGD RERAGKIVGN GFILLILFTI FTSLITYTFM
EPILLFTGAS KYTLGYAVDY LSIYLLGTLF VEISTGLNAF INAQGRPSIA MCSVLIGALL
NIVLDPIFIF WLDMGIKGAA LATILSQACS AIWVLSFLFS RRASLPLERR YMRLDRRIVL
SMFALGISPF IMASTESLVG FVLNSSLKNF GDIYVSALAI LQSAMQFASV PLTGFAQGFV
PIISYNYGHG DKQRVKDCFR IVLIVMFSFN LILMLFMILF PSTVASAFTS DEELIDTVRW
VMPIFLAGMT IFGLQRACQN MFVALGQAKI SIFIALLRKV ILLIPLALLL PHFMGVTGVY
AAEAVSDATA AICCTLLFIW KFPKILGKIK QKEERAAQ
//
