ID A6LJB5_THEM4 Unreviewed; 404 AA.
AC A6LJB5;
DT 24-JUL-2007, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2007, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE SubName: Full=Iron-containing alcohol dehydrogenase {ECO:0000313|EMBL:ABR30016.1};
GN OrderedLocusNames=Tmel_0139 {ECO:0000313|EMBL:ABR30016.1};
OS Thermosipho melanesiensis (strain DSM 12029 / CIP 104789 / BI429).
OC Bacteria; Thermotogota; Thermotogae; Thermotogales; Fervidobacteriaceae;
OC Thermosipho.
OX NCBI_TaxID=391009 {ECO:0000313|EMBL:ABR30016.1, ECO:0000313|Proteomes:UP000001110};
RN [1] {ECO:0000313|EMBL:ABR30016.1, ECO:0000313|Proteomes:UP000001110}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 12029 / CIP 104789 / BI429
RC {ECO:0000313|Proteomes:UP000001110};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Detter J.C.,
RA Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA Mikhailova N., Nelson K., Gogarten J.P., Noll K., Richardson P.;
RT "Complete sequence of Thermosipho melanesiensis BI429.";
RL Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ABR30016.1, ECO:0000313|Proteomes:UP000001110}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 12029 / CIP 104789 / BI429
RC {ECO:0000313|Proteomes:UP000001110};
RX PubMed=19307556; DOI=10.1073/pnas.0901260106;
RA Zhaxybayeva O., Swithers K.S., Lapierre P., Fournier G.P., Bickhart D.M.,
RA DeBoy R.T., Nelson K.E., Nesbo C.L., Doolittle W.F., Gogarten J.P.,
RA Noll K.M.;
RT "On the chimeric nature, thermophilic origin, and phylogenetic placement of
RT the Thermotogales.";
RL Proc. Natl. Acad. Sci. U.S.A. 106:5865-5870(2009).
CC -!- SIMILARITY: Belongs to the iron-containing alcohol dehydrogenase
CC family. {ECO:0000256|ARBA:ARBA00007358}.
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DR EMBL; CP000716; ABR30016.1; -; Genomic_DNA.
DR RefSeq; WP_012056377.1; NC_009616.1.
DR AlphaFoldDB; A6LJB5; -.
DR STRING; 391009.Tmel_0139; -.
DR KEGG; tme:Tmel_0139; -.
DR eggNOG; COG1454; Bacteria.
DR HOGENOM; CLU_007207_0_4_0; -.
DR OrthoDB; 5445534at2; -.
DR Proteomes; UP000001110; Chromosome.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR CDD; cd08186; Fe-ADH-like; 1.
DR Gene3D; 3.40.50.1970; -; 1.
DR Gene3D; 1.20.1090.10; Dehydroquinate synthase-like - alpha domain; 1.
DR InterPro; IPR001670; ADH_Fe/GldA.
DR InterPro; IPR018211; ADH_Fe_CS.
DR InterPro; IPR045910; AdhA-like.
DR InterPro; IPR039697; Alcohol_dehydrogenase_Fe.
DR PANTHER; PTHR11496; ALCOHOL DEHYDROGENASE; 1.
DR PANTHER; PTHR11496:SF102; ALCOHOL DEHYDROGENASE 4; 1.
DR Pfam; PF00465; Fe-ADH; 1.
DR SUPFAM; SSF56796; Dehydroquinate synthase-like; 1.
DR PROSITE; PS00913; ADH_IRON_1; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT DOMAIN 18..375
FT /note="Alcohol dehydrogenase iron-type/glycerol
FT dehydrogenase GldA"
FT /evidence="ECO:0000259|Pfam:PF00465"
SQ SEQUENCE 404 AA; 44056 MW; 29E6CE912C365FEF CRC64;
MWESKVDIYN VFELRCKTTC YFGVGAINKV GDIFDTLKNQ GIDNVIFVTD KVAYKVTGAW
DVIKPELEKR GIKYVIYEDV SPNPTTTQIN EATKLALENG AKAVIGIGGG SPIDAAKSVA
VLLEYTDKTA EELYEGKFVP TKAKPIIAIN TTHGTGTEVD RFAVASILEK EYKPAIAYDC
IYPTFAIDDP QLMKTLPKNQ TIFTAIDAIN HVTEAATTLA ASPYSILLAK ETIRLISRYL
PQAVAHPDDL TARYYLLYAS AIAGISFDNG LLHFTHALEH PLSAVKPDLA HGLGLAILLP
AVVKQIYVAK PEVLADIYNP IVPGLKGIPG EAEKIAVGIE KWLFSLGVTE KLENLGFVEK
DIPKLTKLAL ETPSLGLLLS MAPIKADEKA ISSIYRDSLT YISR
//
