ID POTEM_HUMAN Reviewed; 508 AA.
AC A6NI47;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 2.
DT 27-MAR-2024, entry version 116.
DE RecName: Full=Putative POTE ankyrin domain family member M;
GN Name=POTEM;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
CC -!- SIMILARITY: Belongs to the POTE family. {ECO:0000305}.
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DR EMBL; AL589182; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL929601; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS73609.1; -.
DR RefSeq; NP_001138914.1; NM_001145442.1.
DR AlphaFoldDB; A6NI47; -.
DR SMR; A6NI47; -.
DR BioGRID; 534980; 2.
DR STRING; 9606.ENSP00000448062; -.
DR iPTMnet; A6NI47; -.
DR PhosphoSitePlus; A6NI47; -.
DR BioMuta; POTEM; -.
DR MassIVE; A6NI47; -.
DR MaxQB; A6NI47; -.
DR PaxDb; 9606-ENSP00000448062; -.
DR PeptideAtlas; A6NI47; -.
DR Antibodypedia; 58500; 19 antibodies from 6 providers.
DR DNASU; 641455; -.
DR Ensembl; ENST00000547889.6; ENSP00000448062.2; ENSG00000222036.8.
DR GeneID; 641455; -.
DR KEGG; hsa:641455; -.
DR MANE-Select; ENST00000547889.6; ENSP00000448062.2; NM_001145442.1; NP_001138914.1.
DR AGR; HGNC:37096; -.
DR CTD; 641455; -.
DR DisGeNET; 641455; -.
DR GeneCards; POTEM; -.
DR HGNC; HGNC:37096; POTEM.
DR HPA; ENSG00000222036; Tissue enriched (prostate).
DR neXtProt; NX_A6NI47; -.
DR OpenTargets; ENSG00000222036; -.
DR PharmGKB; PA165479276; -.
DR VEuPathDB; HostDB:ENSG00000222036; -.
DR eggNOG; KOG0676; Eukaryota.
DR GeneTree; ENSGT00940000163068; -.
DR HOGENOM; CLU_000134_9_2_1; -.
DR InParanoid; A6NI47; -.
DR OMA; VCWERPS; -.
DR OrthoDB; 4734228at2759; -.
DR PhylomeDB; A6NI47; -.
DR TreeFam; TF337879; -.
DR PathwayCommons; A6NI47; -.
DR SignaLink; A6NI47; -.
DR BioGRID-ORCS; 641455; 197 hits in 1009 CRISPR screens.
DR ChiTaRS; POTEM; human.
DR GenomeRNAi; 641455; -.
DR Pharos; A6NI47; Tdark.
DR PRO; PR:A6NI47; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; A6NI47; Protein.
DR Bgee; ENSG00000222036; Expressed in buccal mucosa cell and 65 other cell types or tissues.
DR ExpressionAtlas; A6NI47; baseline and differential.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR PANTHER; PTHR24147; ANKYRIN REPEAT DOMAIN 36-RELATED; 1.
DR PANTHER; PTHR24147:SF66; POTE ANKYRIN DOMAIN FAMILY MEMBER D; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 2.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 6.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 4.
PE 3: Inferred from homology;
KW ANK repeat; Reference proteome; Repeat.
FT CHAIN 1..508
FT /note="Putative POTE ankyrin domain family member M"
FT /id="PRO_0000332150"
FT REPEAT 172..201
FT /note="ANK 1"
FT REPEAT 205..234
FT /note="ANK 2"
FT REPEAT 238..267
FT /note="ANK 3"
FT REPEAT 271..300
FT /note="ANK 4"
FT REPEAT 304..333
FT /note="ANK 5"
FT REGION 369..487
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 378..393
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 405..425
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 508 AA; 57067 MW; 786971B0BAFAC804 CRC64;
MVAEAGSMPA ASSVKKPFGL RSKMGKWCRH CFPWCRGSGK SNVGTSGDHD DSAMKTLRSK
MGKWCRHCFP WCRGSGKSNV GTSGDHDDSA MKTLRSKMGK WCCHCFPCCR GSGKSKVGPW
GDYDDSAFME PRYHVRREDL DKLHRAAWWG KVPRKDLIVM LKDTDMNKKD KQKRTALHLA
SANGNSEVVK LLLDRRCQLN ILDNKKRTAL TKAVQCQEDE CALMLLEHGT DPNIPDEYGN
TALHYAIYNE DKLMAKALLL YGADIESKNK HGLTPLLLGV HEQKQQVVKF LIKKKANLNA
LDRYGRTVLI LAVCCGSASI VSLLLEQNID VSSQDLSGQT AREYAVSSRH NVICQLLSDY
KEKQILKVSS ENSNPEQDLK LTSEEESQRL KGSENSQPEE MSQEPEINKG GDRKVEEEMK
KHGSTHMGFP ENLPNGATAD NGDDGLIPPR KSRTPESQQF PDTENEQYHS DEQNDTQKQL
SEEQNTGILQ DEILIHEEKQ IEVAENEF
//
