ID   A6QSD6_AJECN            Unreviewed;      1390 AA.
AC   A6QSD6;
DT   21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT   21-AUG-2007, sequence version 1.
DT   27-MAR-2024, entry version 73.
DE   RecName: Full=Reverse transcriptase domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=HCAG_00292 {ECO:0000313|EMBL:EDN02428.1};
OS   Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus)
OS   (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX   NCBI_TaxID=2059318 {ECO:0000313|EMBL:EDN02428.1, ECO:0000313|Proteomes:UP000009297};
RN   [1] {ECO:0000313|Proteomes:UP000009297}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NAm1 / WU24 {ECO:0000313|Proteomes:UP000009297};
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
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DR   EMBL; CH476655; EDN02428.1; -; Genomic_DNA.
DR   VEuPathDB; FungiDB:HCAG_00292; -.
DR   HOGENOM; CLU_000680_23_1_1; -.
DR   OMA; PSPSEFC; -.
DR   OrthoDB; 2202746at2759; -.
DR   Proteomes; UP000009297; Unassembled WGS sequence.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd01650; RT_nLTR_like; 1.
DR   Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR   Gene3D; 4.10.60.10; Zinc finger, CCHC-type; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR   InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR   InterPro; IPR000477; RT_dom.
DR   InterPro; IPR001878; Znf_CCHC.
DR   InterPro; IPR036875; Znf_CCHC_sf.
DR   PANTHER; PTHR33481; REVERSE TRANSCRIPTASE; 1.
DR   PANTHER; PTHR33481:SF1; REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF14529; Exo_endo_phos_2; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SMART; SM00343; ZnF_C2HC; 2.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF56219; DNase I-like; 1.
DR   SUPFAM; SSF57756; Retrovirus zinc finger-like domains; 1.
DR   PROSITE; PS50878; RT_POL; 1.
DR   PROSITE; PS50158; ZF_CCHC; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00047};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009297};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00047};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00047}.
FT   DOMAIN          298..314
FT                   /note="CCHC-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50158"
FT   DOMAIN          765..1029
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        9..23
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1390 AA;  155795 MW;  8914143856538E00 CRC64;
     MVVMEEIVGR ADGRPREENS DKRQQPTTCG AILTQLSNVL CNGSEDPAIN GKGKEVVEEA
     ARLVRELKVK LGEVMLAKVE DATVATRAQR QPEGVKEAKL SSWAKVAGQG IPEKPVPNRT
     LREITVLRRD CEALPAEEAT PPAIVAAVNA RIVDVTKGKV LAARCLPSGD IILTTDARET
     REALTKSSTW LEVLGQKAKA KHTLYPVMVK GVPMGNTNWK EEQQAIKAIY AQNEGLRRGV
     QIERLSLRRN ASLQAKVGSL VLSVTSPQQA NLLVDNGLII DSIFCDVEIF HREAQVTRCF
     NCHEYGHTAR FCRQAKRCGF CAAKEHDDKE CPARKAGEQP STTELTTWVS ATGGPNGLHA
     DPSPHATMRD TLNLLQYNVH NSARVMVNVY APPPGGYSSE PEESPIGQLQ EVAGMGTDAE
     LVILGDLNVH HERWGGVRVE RNFRMAWQLI AQVDRLGLQL ATPVGATTWQ DRGSPGTTID
     LTFLSPLLHD KLRRCAIAEE ACKGSDHKPI ETTLELTPIP KEAERRNWKN AEPEEVARDC
     QKLYVPQSLD SRQAVKEYAD YLVGFVGTLA DKHATVSKAG LKSKTWWSPR VAKAVEEYKQ
     ARRSQLPEME RLRARCKRNR EIHLAKTANF RDLVDRTRGD PRLMWGLAKW GKERSHLPPQ
     APTVPPLRTG EGADATVETS FEGKAEALRQ RFFPQPEPAD LSDTNMELLQ AEREASNDTI
     SVEDMESLIQ RLPNRKAPGR SGITNEFLKM LGRTFVEAIT ALTNACWHWE TYPDTFKEAK
     TVALRKPGKA DYQTAGAWRP IALLDTIGKI VEAATAKRLR KIAEDHNLLP SQQMGARRGR
     STETAIAQLL AQIRTVWQHP GQVASVLSLD MTGAYDKVLR ERMVHILRRL GIPRDLVGWV
     ASFMTNRKST IAFEGQESDT FDIPAGIPQG SPLSPILFLF YNEELVRICS RPGRPVVCIA
     FVDDVNVMAY GQSTEDNCRE LLRMHRACEE WAARHGAVFA PQKYELMHFT RARNQFNLQA
     ELRLPGQTIQ PKQVMRVLGV WLDSRLRWKG HLDAVAGKMK TQVRALSQTT QSTWGLPLQQ
     ARMVYNMVIR PALTYGAIAW HQPQGQGGTG PAKSGLALKL TTVQNSCLRI VAGAYKRTPT
     STLEAETHTV PLDIHLDGLV AKAVNRMKAS GMAQQIENAC AAIRTRLRHR GVTRGAQRHM
     GAVVHPAALP VDWEQQWIQG AKERATAEMT PEQRANLDQA SYNHWLKREQ LWRWVQRWKR
     REPPWGERHG RPPDKKILKW HTGLRKARST IIIQLRSGKT GLAAFLNRCK VPEFPTPQCP
     CGYEWETVEH VLIHCERWEQ QRQGLIRNGR LDKRMLLDTK EGLHLLSNWW MESGILGQFT
     LARELTHYVP
//