ID A6QTJ5_AJECN Unreviewed; 2501 AA.
AC A6QTJ5;
DT 21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT 21-AUG-2007, sequence version 1.
DT 27-MAR-2024, entry version 90.
DE RecName: Full=Myosin type II heavy chain {ECO:0008006|Google:ProtNLM};
GN ORFNames=HCAG_00701 {ECO:0000313|EMBL:EDN02837.1};
OS Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus)
OS (Histoplasma capsulatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX NCBI_TaxID=2059318 {ECO:0000313|EMBL:EDN02837.1, ECO:0000313|Proteomes:UP000009297};
RN [1] {ECO:0000313|Proteomes:UP000009297}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NAm1 / WU24 {ECO:0000313|Proteomes:UP000009297};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ISY1 family.
CC {ECO:0000256|ARBA:ARBA00007002}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CH476655; EDN02837.1; -; Genomic_DNA.
DR STRING; 339724.A6QTJ5; -.
DR VEuPathDB; FungiDB:HCAG_00701; -.
DR HOGENOM; CLU_000192_5_3_1; -.
DR OMA; QRAMDIE; -.
DR OrthoDB; 1094820at2759; -.
DR Proteomes; UP000009297; Unassembled WGS sequence.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0000350; P:generation of catalytic spliceosome for second transesterification step; IEA:InterPro.
DR GO; GO:0006996; P:organelle organization; IEA:UniProt.
DR CDD; cd01377; MYSc_class_II; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.340; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 3.30.70.1590; -; 1.
DR Gene3D; 1.10.287.660; Helix hairpin bin; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 2.30.30.360; Myosin S1 fragment, N-terminal; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 4.10.270.10; Myosin, subunit A; 1.
DR InterPro; IPR029012; Helix_hairpin_bin_sf.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR009360; Isy1.
DR InterPro; IPR037200; Isy1_sf.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR008989; Myosin_S1_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45615:SF40; MYOSIN HEAVY CHAIN, MUSCLE-RELATED; 1.
DR PANTHER; PTHR45615; MYOSIN HEAVY CHAIN, NON-MUSCLE; 1.
DR Pfam; PF06246; Isy1; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF02736; Myosin_N; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF140102; ISY1 domain-like; 1.
DR SUPFAM; SSF90257; Myosin rod fragments; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Coiled coil {ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000009297}.
FT DOMAIN 86..136
FT /note="Myosin N-terminal SH3-like"
FT /evidence="ECO:0000259|PROSITE:PS51844"
FT DOMAIN 140..835
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REGION 1..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 714..736
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 1616..1654
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1686..1708
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2124..2155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 913..947
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 983..1520
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1556..1590
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1791..1818
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1896..1958
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 38..59
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1628..1654
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 233..240
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 2501 AA; 286294 MW; 27D7A9F93625FB74 CRC64;
MDDELEVSRR RRCESLPSQV TASRPKGAHG PPHPGSGSNL LRTKQRSNSR TNLATSNTFA
PQFIKSEELR RGADQIRGIE GDNDFSGKRY VWLSDPEKAF IKGMVLDDTQ DGHLLVQCDD
GSQREVDSES VDKVNPAKFD RADDMAELTH LNEGSVVHNL LTRYKSDLIY TYSGLFLVTV
NPYCPLPIYT NEYVKMYNGR SREETRPHIF AMADQAFRNL VEEGRNQSIL VTGESGAGKT
ENTKKVIQYL ATVASSPEGS QGRLTSKQNS NLSQQILRAN PILEAFGNAQ TVRNNNSSRF
GKFIRIEFSR AGQISGAFID FYLLEKSRVV KVNSQERSYH IFYQLLRGAD KELRHHLQLS
EQGIEDFWYI RDGNDSISGV SDLDEWNNLM EAFSIMNFSG NDQLSILRTV AAVMHLGNVT
VTKESLRADQ ATLTPEGYES AAKACQLLGI PIDPFVKGLL HPKVKAGREW VEKVQTPEQV
RLALDALAKG IYERGFADLV SRINKQLDRS GTAGDDSCFI GVLDIAGFEI FETNSFEQLC
INYTNEKLQQ FFNHHMFVLE QEEYAREQIE WQFIDFGKDL QPTIDLIELP NPIGIFSCLD
EDCVMPKATD KSFTEKLHSL WGRKSPKYRS SRLNQGFILT HYAAEVEYST EGWLEKNKDP
LNDNVTRLLS SSSDKHIANL FADWAEVDGE HEVSKSRVKK GLFRTVAQRH KEQLSSLMAQ
LHSTHPHFVR CILPNHKKRP KLFDGPLVLD QLRCNGVLEG IRIARTGFPN RLSFTEFRQR
YEVLCPLTAK GYLDGQSAAS LIVENLGLDK SLYRIGLTKM FFRAGVLAEL EEQRDTLIRD
IMTRFQSVVR GFVQRRIANK RLYRTEATRI IQRNFHVYLD LKSSPWWTLF VRMKPLLGAT
RTAGEVKKRD EQIKQLEEKV RNDIVERQKL EEERRRADVE VQRIRKTLES ERALALDKEE
IFKRLQFREI ELSEKLAGAI VDQEGLEDQM DELIASKKKT EEELELRRSQ LEQAAQIISR
LESEKKELQG QITELEKQLQ DIENNHQKRD SEVDRLSQEV KMLNSHLSLK ERKLQDLEAK
LLKSNQNLDI KLANATKELQ FSRKQVKDLV EENRSIRQQI SDLSSTSTGY EELVRRKEGE
ISILRGDVKK LESEKITLEA EKQTLTRRHS DMQQRLRELQ AQTDAMTSEK KNLEREAADV
KKLLEAKISE DAEAGQCRKL LDQQIKDLKE QLNLTSLNES KITNREKKCI SPIDTLRRAT
EARAAAEASC KELQKELINL RERFTKVERA HLDAETAIEK KIVAQASERQ ASLRRDLTAK
SNELDEVEKE RARLAAQVQD LTRTMAESEA FRIRHDQHKE RLERELVTIK GRLAASENDN
RALLNKIQQK NLDIARSNSR ASDTQRSRMV QIQNEKSRLE EVNKQLLRQL GDAQLSITAL
EKQKEKLALS VEDLNHEVTR EHKATRSAEK ASSASNIQLA EANRNLETER QLRIQAQANT
RKLQASVDQA NKELQDCHQQ LILLHKVFNP EADENPSSWE AVKPNLSKSV DMAAVLESVQ
NKLRVTEEKC ARAESQLAEM RRRHADEMAE LDARYSSSKR ALLEEIDQNQ VAVSRSPNHF
KKNSDPVKRY SNPCTPNNRR FNFNDGANDS GRSDRTVDTV AFQKRMDTAA EIGMLQNQLQ
LTEMQNRQLQ SQLERSSPGR DSWQDESPSI RRMQLLEREN GRLHEKLDDS AKKVSALERS
IQSGELTLRD VQARSHEELY DLLNSQEQSR KSLLHAHKSA LADLTDAKGQ LDKIKHSRVS
LEVELRDATS ELKELQLARD QDAAGRSQLL QEFADLQIRL DAETSKVSDL TSSLELYKGR
ADEYFGKLEQ AEIAVLKASR AEQFAKAQAK EAEDTCATIM AERKQMDSLI EDLQRQTQSY
EEKVEDLAAD LDAALQAKRR LQNELEDYRS QRAMDIEDKE ISLEQTRKKY QMEFSTLTNE
LEIEHDISNE RDALLKEKRT LEERLNEASD RLAELAQGEN PSVRNAAEID RELLELRTKL
AQQEDLSSAA VGKMRRAEAL ATEIQKEIVA ERESNAQLFK EKAALEKQLK EAQLKCVDLE
TKGYTSPSQD VRFLHKRIQE LETQLDEQES KRNADQRSIR NVDRTVKDLQ SQIDRRDKMN
AQLSEDISKS RDKIERLLKT VEELQSSDSE NQLQARRAER ELREEREKSL RLERELEAWK
GLRVERGSAT GRSGTVIGLS EVGDRFGGVN ARNSEKAQSM LFRFRAAQAA DLGILDIGRT
RRPKAITSVT SIPVCEKWRG QVLKEISRKV SRIQDQSLSD YQIRDLNDEI NKAMREKWMW
EVQIRNLGGP NYTRGGGRVY DDDGREIPGG GKGYRYFGRA KELPGVKEMF EAAAKKQSRR
GKEEDTDGGG RVVDISRRHV DAAYFGYGLD EEDGTLLEYE SQKEKEAFEN MLKRGEDEAA
DGWAPLPGDA GDGVEWRLPT LEEVQEELVD RRRRRLLDKI L
//
