ID A6QUB2_AJECN Unreviewed; 615 AA.
AC A6QUB2;
DT 21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT 21-AUG-2007, sequence version 1.
DT 27-MAR-2024, entry version 83.
DE RecName: Full=EF-hand domain-containing protein {ECO:0000259|PROSITE:PS50222};
GN ORFNames=HCAG_00968 {ECO:0000313|EMBL:EDN03104.1};
OS Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus)
OS (Histoplasma capsulatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX NCBI_TaxID=2059318 {ECO:0000313|EMBL:EDN03104.1, ECO:0000313|Proteomes:UP000009297};
RN [1] {ECO:0000313|Proteomes:UP000009297}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NAm1 / WU24 {ECO:0000313|Proteomes:UP000009297};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000256|ARBA:ARBA00004137}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004137}; Intermembrane side
CC {ECO:0000256|ARBA:ARBA00004137}.
CC -!- SIMILARITY: Belongs to the NADH dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00005272}.
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DR EMBL; CH476655; EDN03104.1; -; Genomic_DNA.
DR AlphaFoldDB; A6QUB2; -.
DR STRING; 339724.A6QUB2; -.
DR VEuPathDB; FungiDB:HCAG_00968; -.
DR HOGENOM; CLU_021377_1_1_1; -.
DR OMA; QNNRHAL; -.
DR OrthoDB; 48029at2759; -.
DR Proteomes; UP000009297; Unassembled WGS sequence.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005777; C:peroxisome; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0003954; F:NADH dehydrogenase activity; IEA:InterPro.
DR GO; GO:0006116; P:NADH oxidation; IEA:InterPro.
DR Gene3D; 3.50.50.100; -; 2.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR023753; FAD/NAD-binding_dom.
DR InterPro; IPR045024; NDH-2.
DR PANTHER; PTHR43706; NADH DEHYDROGENASE; 1.
DR PANTHER; PTHR43706:SF50; NADH DEHYDROGENASE (UBIQUINONE)-RELATED; 1.
DR Pfam; PF00036; EF-hand_1; 1.
DR Pfam; PF07992; Pyr_redox_2; 1.
DR SMART; SM00054; EFh; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 2.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Peroxisome {ECO:0000256|ARBA:ARBA00023140};
KW Reference proteome {ECO:0000313|Proteomes:UP000009297};
KW Transit peptide {ECO:0000256|ARBA:ARBA00022946};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 27..48
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 462..497
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
SQ SEQUENCE 615 AA; 69561 MW; 367F3741F1058C33 CRC64;
MGNLFTTSSH YEFILLRSRT VRIIYNLFAY CGIFVVIGGV LVVGFFVYDA TTYRHDLSFD
NIQVSELALN PRLGGPKNLP IADVLIDDHD SEAMREQRDK PKLVILGTGW GSVSLLKTLR
PGDYHVTVVS PVNYFLFTPM LPSATVGTIG LRSLVEPVRS IVQRVRGHFL RAEAVDVEFS
EKLVEVSQLD SNGQERRFYL PYDKLVIGVG STTNPHGVKG LEHCNFLKSI DDARKIKNKV
LDNLELACLP STSDEERRRL LSFVVCGGGP TGVEFAAEIF DMLNEDLLRS FPRILRNEIS
VHLIQSRSHI LNTYDQTLSE YAERRFANDQ VDVLTNSRVK EVKKDKILFT QIEDGKPILK
ELPMGFSQST FCKQLAEKLN SQTNKLTLLT DSHLRVNGTP MGDVYAIGDC SSVQNNVADH
IITFLRTIAW EKGKDPEKVH LTFAEWRNVA QRVKRRFPQA SGHLRRLDRL FEQYDKDRSG
TLDFDELREL LVQIDSKLTS LPATAQRANQ QGKYLGLKFN KIAQAMPGMK ANEIDYGDLD
EAVYKAFQYK HLGSLAYIGN AAIFDFNGMS WGGGLLGVYL WRSIYFAQSV SLRTRILLAM
DWSKRAIFGR DMTSF
//
