ID A6QUB3_AJECN Unreviewed; 1765 AA.
AC A6QUB3;
DT 21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT 21-AUG-2007, sequence version 1.
DT 24-JAN-2024, entry version 72.
DE RecName: Full=Sister chromatid cohesion protein {ECO:0000256|RuleBase:RU364107};
GN ORFNames=HCAG_00969 {ECO:0000313|EMBL:EDN03105.1};
OS Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus)
OS (Histoplasma capsulatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX NCBI_TaxID=2059318 {ECO:0000313|EMBL:EDN03105.1, ECO:0000313|Proteomes:UP000009297};
RN [1] {ECO:0000313|Proteomes:UP000009297}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NAm1 / WU24 {ECO:0000313|Proteomes:UP000009297};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364107}.
CC -!- SIMILARITY: Belongs to the SCC2/Nipped-B family.
CC {ECO:0000256|ARBA:ARBA00009252, ECO:0000256|RuleBase:RU364107}.
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DR EMBL; CH476655; EDN03105.1; -; Genomic_DNA.
DR STRING; 339724.A6QUB3; -.
DR VEuPathDB; FungiDB:HCAG_00969; -.
DR HOGENOM; CLU_000901_0_0_1; -.
DR OMA; GSTDWPA; -.
DR OrthoDB; 1409889at2759; -.
DR Proteomes; UP000009297; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003682; F:chromatin binding; IEA:InterPro.
DR GO; GO:0061780; P:mitotic cohesin loading; IEA:InterPro.
DR GO; GO:0010468; P:regulation of gene expression; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR026003; Cohesin_HEAT.
DR InterPro; IPR024986; Nipped-B_C.
DR InterPro; IPR033031; Scc2/Nipped-B.
DR PANTHER; PTHR21704:SF18; NIPPED-B-LIKE PROTEIN; 1.
DR PANTHER; PTHR21704; NIPPED-B-LIKE PROTEIN DELANGIN SCC2-RELATED; 1.
DR Pfam; PF12765; Cohesin_HEAT; 1.
DR Pfam; PF12830; Nipped-B_C; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|RuleBase:RU364107};
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364107};
KW Reference proteome {ECO:0000313|Proteomes:UP000009297};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU364107};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..24
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1440..1559
FT /note="Sister chromatid cohesion C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12830"
FT REGION 264..311
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 684..730
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1566..1593
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1721..1765
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 357..387
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 282..309
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1750..1765
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1765 AA; 195325 MW; CB8C319928C04D5B CRC64;
MKIQQSLLIN ILQLFASSLL MFFSDIPSRY YYIYEYFKCI YLRIKELAKI FKTADFLYIL
ADLKVSRCGR AGKGNNTPLS VVEPSAAKLR RHGIPPGKIS AMQQARNPSI QVVISGHGVS
NSNGAGERLA KALSVDEALQ FSPMTSAPIF GLDSILRPDV GQPSLANLSS THDRKAAGEI
IDTLDDETQA NAGESTRLET TRRHLQEILS GDMTEYEFKL PSRSRVTHNS LKAQLPDTES
LSRGHLGPFA KMVLDNTDVR YRYPSPVTPS PKKKLIVSKP LPSPTLTENV SAARIPESSH
HTESKATLGL QKPMQKPVVL VPSLPLSSQP DEYVHICDQS PSKRRKLNTE DDEKLAALRL
KDQKEEADAA LVKLQELLQE VFEAEDQLEP DTSATEHQSS SKMFRLPKAI DGLGPVLSSE
THSLLQTAMQ KVTGYGRLRD IPTEYLNRIQ KLCEPPVISA QTPDLKLEHV PAEDDTEMWL
RKLDDMRNAL LAICTLLHTM SGEVTIKDLC PEDVIQAIPN VLNHVFDDCL IPVVECRPNG
RDAELFTFFS AHRNILAGLV HQTKKVLHLL ARFLSNVDVA EGTITATEFL ATKLIFVENA
HSDRDSTLGF QKYEAVRRGS MDVLAKIFAK YPEQRPFILD EILVSLEKLP STRQSARQFK
LIDGKHIQLL SALVMQLVQT TALQKSSKGS RRPKRRLLLP KFGQGEGSES EDTDDEADDD
GPRRGTPLEL LSDKVEPLFD NALRSAQYIT KFIVQRAMTS TKTGDQPYRN LLDLFTGDLV
SVLGSTDWPA AELLLRVLAS QMIGLADHDK SPANAKNMAL ELLGWMGCAI SDLTSSVQHL
IPSMDEGDSE LSDYLRQLFD EHLNRSLHAE DVVSVDGPYR IVLESLQERD LGNWQLSSAR
GYVLAQWAKN VCSFYYDPEN RGNISDGESV DHLARTLRNM LSDPRWLESH NNFERIGPHH
ARFAYLLTLL HMGFCKAFDK ILKVLLNSIT SDQAKVRSRS LKSVIQMLEK DPTLLDRDDS
VTTLILRCST DSSPMVRDSA LSLIAKCITL RPALEEDGCR TILSCSADPT VGVRKRCIGS
LKDIYLQTSR KDLKIAIADN LLQRITDMES SVVTQARQVL EEIWFGPFHH PIDSIQDSPQ
TKVSLGELVD LIVGSVEKSD AIVTAFEKFV KSILSDDTKA ASANFKVCKA IVATMFERII
DHADSPNKPT LQALLQSVTV FAKANAKLFT PDQLETLHPY IGHLSTADDL LLFRSVVVIY
RCVLPYLSTA HNTLLKEIQN DLFKSVSKLA RTELNEVMAC LWTIDRVLQN TERLVKLTIS
VLKGIAQAKT LNFDNSSKTD ALGRYPFELR IMALESLGSI CQTWPAQYSQ QQARMALSSV
FEGDSPDLQN IILKSFLEFF SIHEGKAETL VQTSDSAADA ESSTRLAGSL KASENDGAAA
LIAQQFLQNM LHAALSKQDT YALTAIELIA SINRQGLIHP KECAGVLVAL ETSTNPTISK
IAFDTHKMLH EQHESMFDRE YMRAVQDAFH YQRDVVGDPS GAFVRPYTSK LAPLFDIIKP
INGNSNAAQS QTMDGSPVSE EVPAAPTTSS AAAAAGESVD GQLLRQLATA AGSLLMLWEA
RSYLRRLYGI NFHARQKEGK GSSKELNRPP SKVQGVTGDR FWEVVSNLMH CIDSTETMVT
TCRDFALLLS IDDELKVAGD DDRGSHDTTG EGDEIGILLA AAGNSKPGKR KSSVSAGGTP
KKKARGKTLG KKRMSTDIDD ELASD
//
