ID   A6QUC1_AJECN            Unreviewed;       419 AA.
AC   A6QUC1;
DT   21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT   21-AUG-2007, sequence version 1.
DT   27-MAR-2024, entry version 58.
DE   RecName: Full=Ribosome biogenesis protein NOP53 {ECO:0000256|ARBA:ARBA00018339, ECO:0000256|PIRNR:PIRNR017302};
GN   ORFNames=HCAG_00977 {ECO:0000313|EMBL:EDN03113.1};
OS   Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus)
OS   (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX   NCBI_TaxID=2059318 {ECO:0000313|EMBL:EDN03113.1, ECO:0000313|Proteomes:UP000009297};
RN   [1] {ECO:0000313|Proteomes:UP000009297}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NAm1 / WU24 {ECO:0000313|Proteomes:UP000009297};
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
CC   -!- FUNCTION: May play a role in ribosome biogenesis.
CC       {ECO:0000256|PIRNR:PIRNR017302}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000256|PIRNR:PIRNR017302}. Nucleus, nucleoplasm
CC       {ECO:0000256|PIRNR:PIRNR017302}.
CC   -!- SIMILARITY: Belongs to the NOP53 family.
CC       {ECO:0000256|ARBA:ARBA00008838, ECO:0000256|PIRNR:PIRNR017302}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CH476655; EDN03113.1; -; Genomic_DNA.
DR   AlphaFoldDB; A6QUC1; -.
DR   STRING; 339724.A6QUC1; -.
DR   VEuPathDB; FungiDB:HCAG_00977; -.
DR   HOGENOM; CLU_035888_1_0_1; -.
DR   OMA; TEKWTHK; -.
DR   OrthoDB; 2912665at2759; -.
DR   Proteomes; UP000009297; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
DR   InterPro; IPR011687; Nop53/GLTSCR2.
DR   PANTHER; PTHR14211; GLIOMA SUPPRESSOR CANDIDATE REGION GENE 2; 1.
DR   PANTHER; PTHR14211:SF7; RIBOSOME BIOGENESIS PROTEIN NOP53; 1.
DR   Pfam; PF07767; Nop53; 1.
DR   PIRSF; PIRSF017302; Gltscr2; 1.
PE   3: Inferred from homology;
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR017302};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009297};
KW   Ribosome biogenesis {ECO:0000256|ARBA:ARBA00022517,
KW   ECO:0000256|PIRNR:PIRNR017302}.
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          94..114
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          170..204
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          226..304
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          328..356
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        97..114
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        226..262
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        281..296
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        328..354
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   419 AA;  47906 MW;  67E2DCBB5D34B8E3 CRC64;
     MATTIGAPHQ YKQPSRKGKK AWRKHVDMTE VDVGLQRVRE EEIEGGVIAE KSSEDLFVLD
     SKGSDELQRK VRSIKLLKCD EILAQRSAIP SIDNRKRGSS KVTDGITEPK NKRTKSDWVA
     HKEWMRLKQV AKDANLLEHD DNRVISHDPW GEDVAPEFAE ETKFNFLEKP KPIVAPPTTK
     LPPLSLAANR KPVPSIKSPD AGISYNPSFE DWDRLLTMEG QKEVEAEKKR LEEEKAEQER
     LARIEAAKDD NGQARSDDES AWEGFESEYE TAEWLKKKRP ERKTKAQRNK IKRRKEAERK
     AKWEAQLKKR EEQAARAKAI AEAVAAKEEA EKQLKKADDE SSVEGDDRIL RRRPFGKNPV
     PVKPLEIVLP DELQDSLRLL KPEGNLLGDR FRNLIVQGKL EARNPVPLNG KAKRDYTEK
//