ID   A6QVM2_AJECN            Unreviewed;       433 AA.
AC   A6QVM2;
DT   21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT   21-AUG-2007, sequence version 1.
DT   27-MAR-2024, entry version 57.
DE   RecName: Full=RNase H type-1 domain-containing protein {ECO:0000259|PROSITE:PS50879};
GN   ORFNames=HCAG_01429 {ECO:0000313|EMBL:EDN03564.1};
OS   Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus)
OS   (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX   NCBI_TaxID=2059318 {ECO:0000313|EMBL:EDN03564.1, ECO:0000313|Proteomes:UP000009297};
RN   [1] {ECO:0000313|Proteomes:UP000009297}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NAm1 / WU24 {ECO:0000313|Proteomes:UP000009297};
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
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DR   EMBL; CH476655; EDN03564.1; -; Genomic_DNA.
DR   AlphaFoldDB; A6QVM2; -.
DR   VEuPathDB; FungiDB:HCAG_01429; -.
DR   HOGENOM; CLU_000680_26_0_1; -.
DR   OMA; REICKSP; -.
DR   OrthoDB; 3040536at2759; -.
DR   Proteomes; UP000009297; Unassembled WGS sequence.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:InterPro.
DR   CDD; cd09276; Rnase_HI_RT_non_LTR; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR002156; RNaseH_domain.
DR   InterPro; IPR036397; RNaseH_sf.
DR   PANTHER; PTHR33481; REVERSE TRANSCRIPTASE; 1.
DR   PANTHER; PTHR33481:SF1; REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00075; RNase_H; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS50879; RNASE_H_1; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000009297}.
FT   DOMAIN          125..266
FT                   /note="RNase H type-1"
FT                   /evidence="ECO:0000259|PROSITE:PS50879"
SQ   SEQUENCE   433 AA;  48300 MW;  5687EAFC6A0DAF6D CRC64;
     MAARGVLPVF RTTPIATLYR DAGLPSAMVA LEEAKIRFAT RLQVVDEKHP LASRIAPPMI
     TRGRGAGTRQ RSKSKVQRLG ALLPAVNRPT LAIPHYSEGC GTDPTEGVDK KSAAQAFKKW
     WRSQPSTDLY VFSDGSERSL DNSRQVGYGF IVYQGNKQLA SFSAALSPMS HVFDAEAVGA
     CRALECAVKL LPCVTEDSSN PQIWLCLDNT SVIWGIRGSA AASSNWAYNR CHELLRQHNV
     GLKWAPGHMG IEGNEEADRL AKRAVSSTAA PAYGLEATPT VSGVRTVAKQ LSQEARQKWW
     SGACGKLSDW YRGWSFSRPT VEYQVKAPPE LTMPRHALHR WLALRSSHGD FSWYHRRFQH
     ADARLTCVCG HNKSPEHLVL CRHSQRHFLH WPKRPAARPH NRATAVAYLG SLTPTDFVEL
     LDRTQFYTRY CTR
//