ID   A6QWF8_AJECN            Unreviewed;       465 AA.
AC   A6QWF8;
DT   21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT   21-AUG-2007, sequence version 1.
DT   27-MAR-2024, entry version 56.
DE   RecName: Full=D-serine dehydratase-like domain-containing protein {ECO:0000259|SMART:SM01119};
GN   ORFNames=HCAG_01715 {ECO:0000313|EMBL:EDN03850.1};
OS   Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus)
OS   (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX   NCBI_TaxID=2059318 {ECO:0000313|EMBL:EDN03850.1, ECO:0000313|Proteomes:UP000009297};
RN   [1] {ECO:0000313|Proteomes:UP000009297}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NAm1 / WU24 {ECO:0000313|Proteomes:UP000009297};
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
CC   -!- SIMILARITY: Belongs to the DSD1 family.
CC       {ECO:0000256|ARBA:ARBA00005323}.
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DR   EMBL; CH476655; EDN03850.1; -; Genomic_DNA.
DR   AlphaFoldDB; A6QWF8; -.
DR   STRING; 339724.A6QWF8; -.
DR   VEuPathDB; FungiDB:HCAG_01715; -.
DR   HOGENOM; CLU_031639_0_0_1; -.
DR   OMA; EIRPGNF; -.
DR   OrthoDB; 5473289at2759; -.
DR   Proteomes; UP000009297; Unassembled WGS sequence.
DR   GO; GO:0016829; F:lyase activity; IEA:UniProt.
DR   CDD; cd06817; PLPDE_III_DSD; 1.
DR   Gene3D; 3.20.20.10; Alanine racemase; 1.
DR   Gene3D; 2.40.37.20; D-serine dehydratase-like domain; 1.
DR   InterPro; IPR001608; Ala_racemase_N.
DR   InterPro; IPR026956; D-ser_dehydrat-like_dom.
DR   InterPro; IPR042208; D-ser_dehydrat-like_sf.
DR   InterPro; IPR029066; PLP-binding_barrel.
DR   PANTHER; PTHR28004:SF2; D-SERINE DEHYDRATASE; 1.
DR   PANTHER; PTHR28004; ZGC:162816-RELATED; 1.
DR   Pfam; PF01168; Ala_racemase_N; 1.
DR   Pfam; PF14031; D-ser_dehydrat; 1.
DR   SMART; SM01119; D-ser_dehydrat; 1.
DR   SUPFAM; SSF51419; PLP-binding barrel; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000009297}.
FT   DOMAIN          324..444
FT                   /note="D-serine dehydratase-like"
FT                   /evidence="ECO:0000259|SMART:SM01119"
SQ   SEQUENCE   465 AA;  51076 MW;  2F5EE17E67F1055A CRC64;
     MSGVTNYPNA SREGLKAQYV GRMLRDVDGP AAIIDVAVAR KNCQLMLDAA EALGVLFRSH
     VKTHKTTELT KFQVGEQSNP VRLVVSTLAE AEQLQPYLEE CKANGRSIDL IYGLPVQPSS
     FKRLTALGKS LGTASISVLV DNPDIIPFLS QYRETTSDTL GVFIKLDTGN NRAGILPESQ
     QFKDLVAAVH AAEHDDSIGI SLRGFYSHLG HSYSSDSTNE AMDYLAQEVE RCGIAAAYAS
     TVGKYSGSRF LISVGATPTT TAAQNLTSPD TVDPTIKRVK ELFDRSKESY DIELHAGAYV
     TLDMQQLAAH ARPTSSHLSF NDIALTVLAE VGSLYPHREK PEALAACGSL CLGREACRNY
     PGWGVVTPWL EGGEGIRTAE TGWYDPEGDR RGWIMDRISQ EHGILAWHGP RDKVRLLKIG
     EKIRIWPNHC CICIAGFSYV LVVDSSLEGA ERDRVQDVWF SWRGW
//