ID A6QX29_AJECN Unreviewed; 1520 AA.
AC A6QX29;
DT 21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT 21-AUG-2007, sequence version 1.
DT 27-MAR-2024, entry version 90.
DE RecName: Full=Reverse transcriptase {ECO:0008006|Google:ProtNLM};
GN ORFNames=HCAG_01936 {ECO:0000313|EMBL:EDN04071.1};
OS Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus)
OS (Histoplasma capsulatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX NCBI_TaxID=2059318 {ECO:0000313|EMBL:EDN04071.1, ECO:0000313|Proteomes:UP000009297};
RN [1] {ECO:0000313|Proteomes:UP000009297}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NAm1 / WU24 {ECO:0000313|Proteomes:UP000009297};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
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DR EMBL; CH476655; EDN04071.1; -; Genomic_DNA.
DR VEuPathDB; FungiDB:HCAG_01936; -.
DR HOGENOM; CLU_000384_0_1_1; -.
DR OrthoDB; 2150499at2759; -.
DR Proteomes; UP000009297; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006338; P:chromatin remodeling; IEA:UniProt.
DR GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR CDD; cd00024; CD_CSD; 1.
DR CDD; cd09274; RNase_HI_RT_Ty3; 1.
DR CDD; cd01647; RT_LTR; 1.
DR Gene3D; 1.10.340.70; -; 1.
DR Gene3D; 2.40.50.40; -; 1.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR016197; Chromo-like_dom_sf.
DR InterPro; IPR000953; Chromo/chromo_shadow_dom.
DR InterPro; IPR023780; Chromo_domain.
DR InterPro; IPR023779; Chromodomain_CS.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR041588; Integrase_H2C2.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR041373; RT_RNaseH.
DR PANTHER; PTHR24559:SF437; RIBONUCLEASE H; 1.
DR PANTHER; PTHR24559; TRANSPOSON TY3-I GAG-POL POLYPROTEIN; 1.
DR Pfam; PF00385; Chromo; 1.
DR Pfam; PF17921; Integrase_H2C2; 1.
DR Pfam; PF17917; RT_RNaseH; 1.
DR Pfam; PF00665; rve; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SMART; SM00298; CHROMO; 1.
DR SUPFAM; SSF54160; Chromo domain-like; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS00598; CHROMO_1; 1.
DR PROSITE; PS50013; CHROMO_2; 1.
DR PROSITE; PS50994; INTEGRASE; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000009297};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW Transposable element {ECO:0000256|ARBA:ARBA00022464}.
FT DOMAIN 479..658
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT DOMAIN 1137..1299
FT /note="Integrase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50994"
FT DOMAIN 1458..1517
FT /note="Chromo"
FT /evidence="ECO:0000259|PROSITE:PS50013"
FT REGION 1..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 235..259
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1024..1043
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..25
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1520 AA; 172645 MW; 1806F7F015ADA261 CRC64;
MAPRTRAGTA PSGGASTSSP RARTPLPRQE SEIPEPAAHL GMGPPAALPP PRPLHSYVYH
GDNGIKVGDP PNYKGKTLSE FHSFTRALER KFRLNLSQFN THEVRVIYAA SLLEGTPATT
WATKERELER SNAAMTWEEF KNFLLDQIED HRNRAFTAAQ RFNSLRQRDD ENPSDFNARF
EEYWEELSDD LNLLKTQLYL AKLTHKVRTT ISQYQSPPTN RTELVNLASR IYLNNQHHEK
KGNKTPSKQP TTGSKRRHDG SDWITTFVLT AESQAILPVI AGWKKIGPPG HAKFTDGTKC
HRFGIIQTKC EATDSEGTSK GSSLLLHAVN IIDEDVILGL PWLRENNPLI DWVTQAWRYR
LTDEEAAIEE PEEFHRKNLE DKIESIYCVA GDLDLEAGGE AATLTARLAV MSATEGGRTQ
RLFTDYKDVF SEKEAAKFPD TKVRHKIHLE EGATAPYGPL YNLSVKELDV LRKYLEEAQS
KNWIRPSKSP AGAPILFVPK KDGRLRLCVD YRGLNKVTVK DRYPLPLIDE MIDRLSGARV
FSKIDIRDTY HRIRVNENDI WKTAFRTKYG NFEYLVLPFG LCNAPATFQA YINEALRGLV
DVSCIVYLDD ILIFSKTEKE HDTHVREVLD RLKQHQLYAN TEKCSFYTQE IDFLGYIVGV
DGISMDRSRV SAIEDWPAPR TYREVQVFLG FANFYRRFIY AYSRIAAPLT DLLKGSVKGR
KTGPFILTQD AVRAFEELKQ AFADATMLNH FDPGLPSQCE TDASGNGVCG IFSQLTPETF
QRWKDRGLIT SGDTGNGMPV GEGFFTEPTR RREWRPVAFF SKKLSLTQRR YDTHDQEMLA
IVESFKIWRH YLQGCKYPVQ VLTDHANLRY FLTTKSLTGR QARWAELLSE YDFFIRYRPG
RLNPADAPSR RPDYDIVDGD EDPTKGPLPS LQKKLAAGGW GSLKLGNGAG KAAARPYTGG
GELGSPQGTG TEGHELLVPR FAAIELAEDE TVYNLPTQRL LEFIGELQQG DALTAARIQK
LKEEGSGSNL EGASPERGGA AEEPSRWQLG ECGLLLLNGS VFVPRSRAVR QELLRIHHDD
PHAGHFGLEK TEELLRRKYV WDKLRTDVKE YVETCDVCQR IKVPRHKQYG ELAPLPVPKG
PWQDLSMDFI VDLPKSTRVK GYDSILVIVD RFTKMAKYIP THKKVKAPEL ADLFLDAIIR
DHGSPKSLVS DRGSLFTSKY WSAFCYHLTI RRFLSTAFHP QTDGQTERQN QTLEHHLRAF
CSYHQNDWPR HLPTAEFAYN NAKNATLKVS PFYACYGYNP SLPSDVADDV LKGGIDSRNV
ERDRGTEYPS VPEVKARLEL LDRIHGEAAK SIRRAQERQA EYYNRKHLPM KFSIGDQVLL
SAKNIKTTRP CKKLSERWLG PFPIIRVVGK QAYELKLTSG FKSIHPVFHI SYLEPYKQRP
GAEPPRPDGV EIEGNTEYLV EGILDKRMHY SKVQYLVKWE GYPSSENSWE PLEHLENAEE
EIAKYEVASR DRPAARQRCG
//
