ID A6QYC0_AJECN Unreviewed; 616 AA.
AC A6QYC0;
DT 21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT 21-AUG-2007, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE RecName: Full=Anaphase-promoting complex subunit 4-like WD40 domain-containing protein {ECO:0000259|Pfam:PF12894};
GN ORFNames=HCAG_02377 {ECO:0000313|EMBL:EDN05774.1};
OS Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus)
OS (Histoplasma capsulatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX NCBI_TaxID=2059318 {ECO:0000313|EMBL:EDN05774.1, ECO:0000313|Proteomes:UP000009297};
RN [1] {ECO:0000313|Proteomes:UP000009297}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NAm1 / WU24 {ECO:0000313|Proteomes:UP000009297};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
CC -!- SIMILARITY: Belongs to the WD repeat CDC20/Fizzy family.
CC {ECO:0000256|ARBA:ARBA00006445}.
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DR EMBL; CH476656; EDN05774.1; -; Genomic_DNA.
DR AlphaFoldDB; A6QYC0; -.
DR STRING; 339724.A6QYC0; -.
DR VEuPathDB; FungiDB:HCAG_02377; -.
DR HOGENOM; CLU_014831_6_0_1; -.
DR OMA; PVKSHHG; -.
DR OrthoDB; 20041at2759; -.
DR Proteomes; UP000009297; Unassembled WGS sequence.
DR GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR GO; GO:0010997; F:anaphase-promoting complex binding; IEA:InterPro.
DR GO; GO:0097027; F:ubiquitin-protein transferase activator activity; IEA:InterPro.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR024977; Apc4-like_WD40_dom.
DR InterPro; IPR033010; Cdc20/Fizzy.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19918; CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED; 1.
DR PANTHER; PTHR19918:SF68; FI02843P; 1.
DR Pfam; PF12894; ANAPC4_WD40; 1.
DR Pfam; PF00400; WD40; 3.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000009297};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT DOMAIN 328..394
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
FT REPEAT 338..379
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 421..453
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 552..585
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 1..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 80..139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 594..616
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 30..58
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 83..107
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 616 AA; 66824 MW; B6AE5114F2997A15 CRC64;
MATATVSTPL KSHHGLFSSK TAGGRMPLTP SPRSRTTSIA TNVSNHSSPF TPPRQSSDST
YVAAQSVYGG NLSSHFARSI SRTVSRTHRD SPKSNIAKTR KSPRHLELGV SDWTLTGTGP
ATGQTPTKKK EPAFRSRTSK TTIRLPHNTA DRFIPNRSAS EGLATAGTAK PDEHQRPKTS
EGSAVLANAA SAFHIGSREN DDDIASALEN LGLDDHDNTT YSRPAPDAVA YKSSLASACD
ISLNTRILAF KPPPPESSKP IDLRSQYNRP LKPANSQSAQ FRRRVQTAPE RVLDAPGLVD
DYYLNLLDWS SGNQVAIGLE RNVYVWSAET GSVNCLLETS PDTYVSSVKW SGDGAYVGVG
LGTGEVQIWD VEEGTKLRSM FGHETRVGVM GWNKHTLSTG ARSGLIFNHD VRIAQHKTAE
LVSHTSEVCG LEWRSDGAQL ATGGNDNLVS IWDARFLSAP KFTKTNHRAA VKALSWCPWQ
LNLLATGGGS YDRHIHFWNT TTGARTNSID TGSQVTSLRW SNHYRELVSS SGFPDNSLSI
WSYPSLVRNV EIPAHETRVL HSCLSPDGQM LATAAADESL KFWKVFERKP GTTAAASREG
AVGSKGSQMA KQMTIR
//
