ID   A6R1X6_AJECN            Unreviewed;       487 AA.
AC   A6R1X6;
DT   21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT   21-AUG-2007, sequence version 1.
DT   27-MAR-2024, entry version 53.
DE   RecName: Full=Reverse transcriptase domain-containing protein {ECO:0000259|PROSITE:PS50878};
GN   ORFNames=HCAG_03634 {ECO:0000313|EMBL:EDN07103.1};
OS   Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus)
OS   (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX   NCBI_TaxID=2059318 {ECO:0000313|EMBL:EDN07103.1, ECO:0000313|Proteomes:UP000009297};
RN   [1] {ECO:0000313|Proteomes:UP000009297}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NAm1 / WU24 {ECO:0000313|Proteomes:UP000009297};
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CH476657; EDN07103.1; -; Genomic_DNA.
DR   AlphaFoldDB; A6R1X6; -.
DR   VEuPathDB; FungiDB:HCAG_03634; -.
DR   HOGENOM; CLU_560154_0_0_1; -.
DR   OMA; FILIPNN; -.
DR   OrthoDB; 2202233at2759; -.
DR   Proteomes; UP000009297; Unassembled WGS sequence.
DR   CDD; cd01650; RT_nLTR_like; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR000477; RT_dom.
DR   PANTHER; PTHR33481; REVERSE TRANSCRIPTASE; 1.
DR   PANTHER; PTHR33481:SF1; REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000009297}.
FT   DOMAIN          97..374
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
SQ   SEQUENCE   487 AA;  54897 MW;  2AA4C5E8985C75FC CRC64;
     MLIRDLKFSQ QRQFNVPEKT RAAPVFQKPP EGHGDVATLE KTQLIAKDFS ELRIHFWPDR
     NTIGVQSTSP GTDGITVRML KACWQHVSLF IQQLYNCCLR LCHFPRAWKL AEVAMIPKVG
     KRDRSSVRSW RPIALLSVIS KGLERIIARR LAYTALIHGI VSPQHGGALP RRSAMDLVAA
     FTHEVEAAFA QNKEVSMVTM DVQGAFDAVL RRRLLQRMAQ QGWPRELLQL IDSFLTERRA
     QVRLEGTTTA AHQMQCGTPQ GSPLSPILFL LYLAELLWQN SELRFGYADD LNIWRATHSL
     DNNATLLRQD IQSILRWGEI NKVAFAPEKL EMIHLTRKRH NEAPAVVVSE DLTVHPVTAP
     AGQEPALRWL GVHFDRRLTW RPHVSTRAKK ARAVAQHIRS LGKTRDGPPA DALRKAVTTC
     VVPSLLYGTE AWYGGRTQPT RCGCAAARLD TYLYELSVFP ICKGCIKQAV NLVSHPVTLS
     LVQSFRL
//