ID   A6R6R8_AJECN            Unreviewed;       628 AA.
AC   A6R6R8;
DT   21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT   21-AUG-2007, sequence version 1.
DT   27-MAR-2024, entry version 64.
DE   RecName: Full=DUF676 domain-containing protein {ECO:0000259|Pfam:PF05057};
GN   ORFNames=HCAG_05326 {ECO:0000313|EMBL:EDN08827.1};
OS   Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus)
OS   (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX   NCBI_TaxID=2059318 {ECO:0000313|EMBL:EDN08827.1, ECO:0000313|Proteomes:UP000009297};
RN   [1] {ECO:0000313|Proteomes:UP000009297}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NAm1 / WU24 {ECO:0000313|Proteomes:UP000009297};
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
CC   -!- SIMILARITY: Belongs to the putative lipase ROG1 family.
CC       {ECO:0000256|ARBA:ARBA00007920}.
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DR   EMBL; CH476659; EDN08827.1; -; Genomic_DNA.
DR   AlphaFoldDB; A6R6R8; -.
DR   STRING; 339724.A6R6R8; -.
DR   VEuPathDB; FungiDB:HCAG_05326; -.
DR   HOGENOM; CLU_008869_0_0_1; -.
DR   OMA; HVVHSKI; -.
DR   OrthoDB; 2575120at2759; -.
DR   Proteomes; UP000009297; Unassembled WGS sequence.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR007751; DUF676_lipase-like.
DR   PANTHER; PTHR47842:SF3; DUF676 DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR47842; EXPRESSED PROTEIN; 1.
DR   Pfam; PF05057; DUF676; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000009297}.
FT   DOMAIN          88..223
FT                   /note="DUF676"
FT                   /evidence="ECO:0000259|Pfam:PF05057"
FT   REGION          34..74
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          350..381
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          506..537
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        40..66
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        514..537
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   628 AA;  70488 MW;  097E7E9436E4BD28 CRC64;
     MSEQITQRPA SPGGSPDFNI PITMHRADTI HLTPYSAPLP HVDDDHDAQI ERKGRSPTRS
     RVKEDNRSPS MQSLLPVCSN RDGRRTLLLI YIHGFVGSDT SFKKFPVHVH NLLTVMLSES
     HVVHSKIYPR YKTRKAIELV RDDLSYWLCP HESPDTDIVL VGHSLGGILA AEIALLGPSD
     PQGPEMFKHR IMGTINLDVP FLGLHHRVIT TGFGSLFRSK IKKKDPRNQP FPVDSSIMKP
     SISSPDDPNF DPMFLNDTRL TERSQLDGAF NFILKNSNQL VDATKKYISS HVEFGLCIAD
     YSGLKRRYKR LRELEDIDDC SPRRDGSGRS YRRIRFINYY TASTGKIKYP ASGSNGDNCP
     NTSVLDGRSA STAPTSPSEL GHVVSLSVDP RTPTEEKTGN PVALSQAKNE EEISAEIHQL
     VVEHTHSAPE NSHTILAEDT YLDFSPQPRR PPEFDHPSSY VSKALLKEAQ KDHSRQMKAY
     EKAVKEGEKK IKAVHKLTSK QELAAEKEQM QRNKESLFPT SSPTNHSHSP QANGVLLDGN
     NEVESTRKVK KDRKFCALPP RETNGERDPL WVRVYMEGVD EVTAHQSLFV SRNAAYDRLV
     GDVAARIEGW VQDDLTTQVL KNALEEKE
//