ID A6RA07_AJECN Unreviewed; 523 AA.
AC A6RA07;
DT 21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT 21-AUG-2007, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=Carboxylic ester hydrolase {ECO:0000256|RuleBase:RU361235};
DE EC=3.1.1.- {ECO:0000256|RuleBase:RU361235};
GN ORFNames=HCAG_05795 {ECO:0000313|EMBL:EDN09992.1};
OS Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus)
OS (Histoplasma capsulatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX NCBI_TaxID=2059318 {ECO:0000313|EMBL:EDN09992.1, ECO:0000313|Proteomes:UP000009297};
RN [1] {ECO:0000313|Proteomes:UP000009297}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NAm1 / WU24 {ECO:0000313|Proteomes:UP000009297};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
CC -!- SIMILARITY: Belongs to the type-B carboxylesterase/lipase family.
CC {ECO:0000256|ARBA:ARBA00005964, ECO:0000256|RuleBase:RU361235}.
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DR EMBL; CH476661; EDN09992.1; -; Genomic_DNA.
DR AlphaFoldDB; A6RA07; -.
DR ESTHER; ajecg-c0ns03; Fungal_carboxylesterase_lipase.
DR VEuPathDB; FungiDB:HCAG_05795; -.
DR HOGENOM; CLU_006586_10_3_1; -.
DR OMA; SIAHHIM; -.
DR OrthoDB; 3203989at2759; -.
DR Proteomes; UP000009297; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 2.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR002018; CarbesteraseB.
DR InterPro; IPR019826; Carboxylesterase_B_AS.
DR PANTHER; PTHR11559; CARBOXYLESTERASE; 1.
DR PANTHER; PTHR11559:SF240; CARBOXYLIC ESTER HYDROLASE; 1.
DR Pfam; PF00135; COesterase; 2.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR PROSITE; PS00122; CARBOXYLESTERASE_B_1; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361235};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009297};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..28
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 67..128
FT /note="Carboxylesterase type B"
FT /evidence="ECO:0000259|Pfam:PF00135"
FT DOMAIN 129..484
FT /note="Carboxylesterase type B"
FT /evidence="ECO:0000259|Pfam:PF00135"
SQ SEQUENCE 523 AA; 58064 MW; C7DF4D3E5479C7C4 CRC64;
MPLIKRAIWL ISVPIIFLLV LLALRLSVLN TYLDVEDLCY RWFPFISWQV ILPSWARVAV
VLGGTETPAV TLRQGTVVGK VLRDNLPKPV EAFLGIPYAL PPTNERRFTP PVPVHASNDA
IDATSYGKRL GAFGFLSSKV AAKGNALNVG LRDQNLLLRW VHENIEAFGG NPDDVALFGL
SAGAHSEGMP SLFRRVIMES GAATSRAVYP YNHSLHELQF KEFLVEAGCS GLEEDGIMPC
LRSKPALTIA LASSKIFSRY ESSDRWAFQP VIDGDIIKQA PIQAWKAGNW NKVSILTGFN
TNEGTSFVPS EMSESEEFIN FFRLLIPAMP EKDLEKLDQL YPDPLKYPSS PYVETRNIRV
GAQFKRVEAA YGNFAYICPV RQTVHHASAG QQAPVYLYHW ALNKTVKGGA SHADQTEYET
YSRGVRQISA AQKEIAGTLH AYFTSFLTTG DPNDVPGRFP DRPEWKSFGG RWSKKNRTLM
LFGEGNDERA GGGGIGIPAQ IANDVWSQDE CEFWSNRSIL TES
//
