ID   A6RA28_AJECN            Unreviewed;       662 AA.
AC   A6RA28;
DT   21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT   21-AUG-2007, sequence version 1.
DT   24-JAN-2024, entry version 74.
DE   RecName: Full=NUC153 domain-containing protein {ECO:0000259|Pfam:PF08159};
GN   ORFNames=HCAG_05816 {ECO:0000313|EMBL:EDN10013.1};
OS   Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus)
OS   (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX   NCBI_TaxID=2059318 {ECO:0000313|EMBL:EDN10013.1, ECO:0000313|Proteomes:UP000009297};
RN   [1] {ECO:0000313|Proteomes:UP000009297}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NAm1 / WU24 {ECO:0000313|Proteomes:UP000009297};
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000256|ARBA:ARBA00004604}.
CC   -!- SIMILARITY: Belongs to the WD repeat NOL10/ENP2 family.
CC       {ECO:0000256|ARBA:ARBA00005264}.
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DR   EMBL; CH476661; EDN10013.1; -; Genomic_DNA.
DR   AlphaFoldDB; A6RA28; -.
DR   STRING; 339724.A6RA28; -.
DR   VEuPathDB; FungiDB:HCAG_05816; -.
DR   HOGENOM; CLU_009923_0_1_1; -.
DR   OMA; CFDSEVT; -.
DR   OrthoDB; 152730at2759; -.
DR   Proteomes; UP000009297; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR040382; NOL10/Enp2.
DR   InterPro; IPR012580; NUC153.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   PANTHER; PTHR14927:SF0; NUCLEOLAR PROTEIN 10; 1.
DR   PANTHER; PTHR14927; UNCHARACTERIZED; 1.
DR   Pfam; PF08159; NUC153; 1.
DR   Pfam; PF00400; WD40; 1.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
PE   3: Inferred from homology;
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009297};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   WD repeat {ECO:0000256|ARBA:ARBA00022574}.
FT   DOMAIN          492..520
FT                   /note="NUC153"
FT                   /evidence="ECO:0000259|Pfam:PF08159"
FT   REGION          464..489
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          510..662
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        515..529
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        595..616
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        644..662
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   662 AA;  73980 MW;  084CEC569D75B8FB CRC64;
     MKLSNSSSVP VYTISGSSTA RPLPEWLARK RKRSLKNDPE YANRVELLQD FEFEEASQCI
     RVSEDGQWVM STGCHYTTRL PRYGRDLIYD RQSAEALIPS VGVNQDGMGE VYRLNLEQGR
     YMKAYEVEVG GDDFSSAGGG ALQGGINTGS VNTAAIAEES HNLLAFGTSI GTVELWDPRA
     RARAGILLPP SDSQLGDTKS EITALEFHRS GLTLATGSSQ GLVHLFDLRS PTPLLKKDQG
     YGYPIHTINF LTSSIATREQ TLEPKILTSD KRIIKIWDAR DGKPWTSVEP AVDINSVAWC
     KDSGMLLTAN EGRQQHAFFI PQLGPAPKWC AFLDNIVEEM AENPNDPQAF AGQAGSVYDN
     FKFLTVPQLR SLNLDHLIGR TTLLRPYMHG FFVAQRLYEE ARLISHPFVW EEERAKRIKE
     KIDQERESRI RGKRKISVNV NKKLAEKLLE KENRNARRQV QRVLEHGGDE EMGDTAEAEP
     SQSSRPDNLL NDSRFAKLFE DEDFAVDETS REFRELNSST ATTTPAVRPE RGLTTVEEEV
     IDEVPGSSSE EESSADEKFS HAKSSGRIST ASYKKSKRPP PRMQVSSSSK TTQARDKSFE
     SKVHKLRTKD RTPKTTAVGE KTVTFAPQPK SRPRPAIVPE NGNASKHSKD RRSASGNTFR
     RM
//