ID A6RB90_AJECN Unreviewed; 1134 AA.
AC A6RB90;
DT 21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT 21-AUG-2007, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE RecName: Full=26S proteasome regulatory subunit RPN2 {ECO:0000256|PIRNR:PIRNR015947};
GN ORFNames=HCAG_06228 {ECO:0000313|EMBL:EDN10425.1};
OS Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus)
OS (Histoplasma capsulatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX NCBI_TaxID=2059318 {ECO:0000313|EMBL:EDN10425.1, ECO:0000313|Proteomes:UP000009297};
RN [1] {ECO:0000313|Proteomes:UP000009297}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NAm1 / WU24 {ECO:0000313|Proteomes:UP000009297};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
CC -!- FUNCTION: Acts as a regulatory subunit of the 26S proteasome which is
CC involved in the ATP-dependent degradation of ubiquitinated proteins.
CC {ECO:0000256|PIRNR:PIRNR015947}.
CC -!- SIMILARITY: Belongs to the proteasome subunit S1 family.
CC {ECO:0000256|ARBA:ARBA00006308, ECO:0000256|PIRNR:PIRNR015947}.
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DR EMBL; CH476661; EDN10425.1; -; Genomic_DNA.
DR AlphaFoldDB; A6RB90; -.
DR STRING; 339724.A6RB90; -.
DR VEuPathDB; FungiDB:HCAG_06228; -.
DR HOGENOM; CLU_002323_0_1_1; -.
DR OMA; IMFGRQE; -.
DR OrthoDB; 151732at2759; -.
DR Proteomes; UP000009297; Unassembled WGS sequence.
DR GO; GO:0008540; C:proteasome regulatory particle, base subcomplex; IEA:UniProtKB-UniRule.
DR GO; GO:0030234; F:enzyme regulator activity; IEA:UniProtKB-UniRule.
DR GO; GO:0042176; P:regulation of protein catabolic process; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR016642; 26S_Psome_Rpn2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR002015; Proteasome/cyclosome_rpt.
DR InterPro; IPR048570; PSMD1_RPN2_N.
DR InterPro; IPR040623; RPN2_C.
DR PANTHER; PTHR10943; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10943:SF2; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1; 1.
DR Pfam; PF13646; HEAT_2; 1.
DR Pfam; PF01851; PC_rep; 1.
DR Pfam; PF18004; RPN2_C; 1.
DR Pfam; PF21505; RPN2_N; 2.
DR PIRSF; PIRSF015947; 26S_Psome_Rpn2; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
PE 3: Inferred from homology;
KW Proteasome {ECO:0000256|ARBA:ARBA00022942, ECO:0000256|PIRNR:PIRNR015947};
KW Reference proteome {ECO:0000313|Proteomes:UP000009297};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 6..134
FT /note="26S proteasome non-ATPase regulatory subunit 1/RPN2
FT N-terminal"
FT /evidence="ECO:0000259|Pfam:PF21505"
FT DOMAIN 197..439
FT /note="26S proteasome non-ATPase regulatory subunit 1/RPN2
FT N-terminal"
FT /evidence="ECO:0000259|Pfam:PF21505"
FT DOMAIN 886..1059
FT /note="26S proteasome regulatory subunit RPN2 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18004"
FT REGION 358..403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 939..1006
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1112..1134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 378..396
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 941..955
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 970..1006
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1134 AA; 124275 MW; F559EED4832E15BD CRC64;
MVGLVSADGL VGFLSEPDPE LKIFALKALD AQVDLLWTEI ADSIDRIEAL YEDESFPERE
LAALLASKVY YHLQEYNESM VFALGAGKLL NLDHGGEFEE TIISKCIDTF ISISASPKTQ
NAAQTANKTP RLNTSFPLTT NGATSTSAGL TSPITPFSQS ALPSKSLLSR KDSISLETGG
EDTGAYPSEL TLVVQRGVQK QLQAVIERLF EQCFREKRYR QVVGIAVEAK NLDVLRAAIL
RASEDEKKTE ESSRSGEELK EYVLDICMSV VQERAFRNEI LKLILELLNE IPSPDYFSIA
KCVVYLNEHS MASEILRQLV EKGDPRSLSV AYQISFDLYD NSTQEFLRKV RQEISQLIPA
SNESESQDTE DDGSAAKETD SLLQNQEGTV NSSNSRRLGS REEKYKLSED AQAALKSIGD
IIDGVNSIQL NLEFLYRNNK ADIAVLNKIK DSLEARNSIF HNAVTLCNAF MHAGTTHDKF
FRDNLEWLGK AVNWSKFTAT AALGVIHRGN LTQGQKLLAP YLPKDNIAGV GGSGSVYSQG
GSLYAFGLIY ANHEGWAVDL IREHFTKATE EVVQHGGALG LGVAGMATGD EGIYNDLKAV
LETDSALNGE AVGLAMGLVM LGTGNMKALE DMIRYAHDTQ HEKIIRGVAM GMALIMYGRQ
EAADELINGL LGDPDPTLRY GGIMAIALAY CGTGSNRAVR RLLHVAVSDV SDDVRRVAVL
SLGFISSAKH QSVPRIVELL SESYNPHVRY GATMALGISC AGTGLDEAVD LLEPMLKDPT
DFVRQGALIA LAMVLVQQNE TMNPKVGIIR KTMQKMITDR HEDAMAKFGC ALALGIIDAG
GRNCTISLQT QTGNLNMPGI IGMAVFIQYW YWFPLSHFLS LSFTPTAVIG VDQRLEVPIF
KFHSNTRPSL FDYPPEQQVK ADEAPEKVKT AVLSTTAQAI RRAQRREKQQ RRESMDIDQT
PATPKVSTQH LDKMDVDETE VKTEEEGNDR VKEETPTEAP KRKAEKEKVG YELENMSRVL
PAQLKFLTFP DPRYEPVKRP TGGVVVVLDK TPSEPREIIE LRASRETKLA AAGETIQDRI
NAAMSALEQP AVAGTFGGAA AAAGVLTAVD EDEEGAEEAP VPNEFDYYSD AAED
//
