ID   A6RBD4_AJECN            Unreviewed;       720 AA.
AC   A6RBD4;
DT   21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT   21-AUG-2007, sequence version 1.
DT   24-JAN-2024, entry version 76.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EDN10469.1};
GN   ORFNames=HCAG_06272 {ECO:0000313|EMBL:EDN10469.1};
OS   Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus)
OS   (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX   NCBI_TaxID=2059318 {ECO:0000313|EMBL:EDN10469.1, ECO:0000313|Proteomes:UP000009297};
RN   [1] {ECO:0000313|Proteomes:UP000009297}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NAm1 / WU24 {ECO:0000313|Proteomes:UP000009297};
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000256|ARBA:ARBA00006082}.
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DR   EMBL; CH476661; EDN10469.1; -; Genomic_DNA.
DR   AlphaFoldDB; A6RBD4; -.
DR   STRING; 339724.A6RBD4; -.
DR   VEuPathDB; FungiDB:HCAG_06272; -.
DR   HOGENOM; CLU_011171_2_0_1; -.
DR   OMA; LVCKRSC; -.
DR   OrthoDB; 1369806at2759; -.
DR   Proteomes; UP000009297; Unassembled WGS sequence.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0061982; P:meiosis I cell cycle process; IEA:UniProt.
DR   GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 2.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms-like.
DR   InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR   InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR   PANTHER; PTHR10073:SF41; MISMATCH REPAIR PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05820)-RELATED; 1.
DR   Pfam; PF13589; HATPase_c_3; 1.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR   SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009297}.
FT   REGION          297..337
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          405..428
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          603..631
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          649..672
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        303..320
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        323..337
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        603..620
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        652..672
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   720 AA;  79905 MW;  D8175027B5A39F66 CRC64;
     MSIAQLPPDT IRAVRSNSVL SDPCALAKEL IDNSLDAGAT CISVEVAANT LDTIQVKDNG
     TGIHPNDRHL VCKRSCTSKL RSIDDLENIG GSTLGFRGEA LASAAEMCGT TVRVDEFLRF
     VPVRKRRALK SASKTLNRMK KVLNAYVLSR PEIRLSFKIL KRKNDSSWIY ASNKHPTVST
     AMLRVIGAEA ISQCTTITWP QIQDERDDSL RPMSTSNGVA KELVELFKSH IRSGSLCDSG
     QTPPVDPFCF IHLHCRPGIY DVNVEPLKND VLFEDSKLVI SMAGNLFKTV YGETKPRHTH
     QRNCQIENQP SSSRMIRPLD SRPANNQRDH EVEESPLFRH ISSSATKDCH SIECICASSS
     KAKKDNMLAG SCVDTYACPR AAESNLSLLN SSLLTNPWLL AKGQHVTPRK EDAQSRDLNS
     QLLTPAYQDG RSRLDEKRIK NCGANSVFAG PPYPTPVSTR TLETRLVEGD NDKSSTDVRK
     PQTSELCNVP QLTASHKSKQ RKSSGVLGSL DAWIRNCRDA PSHSTEESHA VGILQQSEPD
     GNELTETDIA GRFGKEDNAV TTSLSHGDFS AGLSPRTSLN ALGIHLNSAH TNTKNHCQPL
     AISQEEDDDP DYRIHRLTDN RPTSRPTSPS HEMIAEALDF EYRKKTAIQL HRKRQQQQQQ
     QQQQQISTQS TLHSWAGANN AKISQGSPHQ NRYRRAKAHL VNQLPELELP RHEITSRRPK
//