ID A6RCX1_AJECN Unreviewed; 1554 AA.
AC A6RCX1;
DT 21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT 21-AUG-2007, sequence version 1.
DT 27-MAR-2024, entry version 97.
DE RecName: Full=RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012493};
DE EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
GN ORFNames=HCAG_07479 {ECO:0000313|EMBL:EDN11026.1};
OS Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus)
OS (Histoplasma capsulatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX NCBI_TaxID=2059318 {ECO:0000313|EMBL:EDN11026.1, ECO:0000313|Proteomes:UP000009297};
RN [1] {ECO:0000313|Proteomes:UP000009297}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NAm1 / WU24 {ECO:0000313|Proteomes:UP000009297};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
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DR EMBL; CH476663; EDN11026.1; -; Genomic_DNA.
DR VEuPathDB; FungiDB:HCAG_07479; -.
DR HOGENOM; CLU_000384_0_0_1; -.
DR OrthoDB; 5490242at2759; -.
DR Proteomes; UP000009297; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006338; P:chromatin remodeling; IEA:UniProt.
DR GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR CDD; cd00303; retropepsin_like; 1.
DR CDD; cd09274; RNase_HI_RT_Ty3; 1.
DR CDD; cd01647; RT_LTR; 1.
DR Gene3D; 1.10.340.70; -; 1.
DR Gene3D; 2.40.50.40; -; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 2.40.70.10; Acid Proteases; 1.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR016197; Chromo-like_dom_sf.
DR InterPro; IPR000953; Chromo/chromo_shadow_dom.
DR InterPro; IPR023780; Chromo_domain.
DR InterPro; IPR023779; Chromodomain_CS.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR041588; Integrase_H2C2.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR041373; RT_RNaseH.
DR PANTHER; PTHR24559:SF437; RIBONUCLEASE H; 1.
DR PANTHER; PTHR24559; TRANSPOSON TY3-I GAG-POL POLYPROTEIN; 1.
DR Pfam; PF00385; Chromo; 1.
DR Pfam; PF17921; Integrase_H2C2; 1.
DR Pfam; PF17917; RT_RNaseH; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SMART; SM00298; CHROMO; 1.
DR SUPFAM; SSF54160; Chromo domain-like; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS00598; CHROMO_1; 1.
DR PROSITE; PS50013; CHROMO_2; 1.
DR PROSITE; PS50994; INTEGRASE; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Reference proteome {ECO:0000313|Proteomes:UP000009297};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW Transposable element {ECO:0000256|ARBA:ARBA00022464}.
FT DOMAIN 611..799
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT DOMAIN 1176..1339
FT /note="Integrase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50994"
FT DOMAIN 1480..1539
FT /note="Chromo"
FT /evidence="ECO:0000259|PROSITE:PS50013"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 326..347
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1530..1554
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 31..67
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 12..26
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1536..1554
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1554 AA; 178790 MW; A17E34033B99BAF6 CRC64;
MASTRSIRRT TSPMEPDSEH SSEGDTSSED LNAIEAEKIA VTRRIKKLQA EKELRELQHR
CNTLLQELDE TIPATRNTLE AHPNHGRDAT SVNCNRENAT SILGPPEPTL QAPNTLVESA
VTTVSGRRSR VPLWQLELRD PGMSGHPPRR DVEKFRGQSM KEFENFVTAA IAFHASDLDY
YNEHDHRKVI EAVTHFNVEM QQRWYQHTHD MRILPPWEEF VSWMQCQVTD PDKSFRDADR
QYWKTEQQED QTVQQFASHL QSIEGRLRHP YSEYHRKSHL YMKVLPSIRR EFDKYATKLE
ELSYDATLHK LAIAESNLPE RRKKLKEKSN FRNPTQSFNN RNNAEHKGLK KRLKRAIQLA
MATISAESRC KNALSFNVTV EITTPKSLQK VLALVDSGSE VNCVDEFWAK DHNLEAAHRK
TKMVKSIDGC IMRSFGEYNI ATTVTDHKGN AQQTSHSFHA MKMKDYNLVL GFPWLKQTNP
LIDWSDGQFF FRSSGDEQQP QIISEQDVLA EVLTGARVGM LVVLPTECSK DPKHAPRVFS
AAYSDLPTGL PDYVMPYAHI FSEEAAISAQ RPEEAEHRID LEPGARPPFM PIYNLSETEL
AALREYLKNA LDKGWIQPSS SPAGAPILFV PKKDGGLRLC VDYRGLNRIT IKNRYPLPLI
SELLDRLSKA KVFTKLDLRD AYHRILIAAK DRWKTAFRTR YGHFEYVVMP FGLANAPATF
QAYINNALSD LLDICCVVYL DDILIFSNSK QEHKVHVTKV LERLERANLF AKLSKSPLFE
LTKGSKKGER KATFMWTESA QSAFNELKSR FMRAPLLAHF DPARRIQIEP DASTFAVAAI
LSQLQDDGHW HPVAFWSRKL IDAETRYDTH DKELLAIVAA FKNWRHYLEG SQYPIQVWSD
HANLQYFMTT KELNRRQARW AEALSAYDFV LLHRPGSKNP ADGPSRRADY SEAYNGQTML
PTLQQKLKHG VKLGWEADTS FQNDISSDVV CARVSNEQNA PFNERKALHT STSYTSRVNS
SPLMRVEQYM PRIAVNKAIL GDSAYTEMPE SFTSFLSKAQ KIDSFAAEQR EKVKEKGMTV
AENMLWTISE DDILRADGRA YVPQQKALID EIISANHDDP QGGHFGIKKS IDSIQDKYYW
HGLVRDVKDY ISTCDTCQRV KPKRHRQYGE LGTIPLPSNP FESITMDFIT GLPASTFLHQ
TYDAILVIVD IYTKFTIYIP CTKNITADEL AEIVYTKFYT IYGVPKNHIS DRGSLFTSHY
WSTFCYMLGA RRKLSTAFHP QTDGQTERQN QTLEHYLRCF VNYHQDDWAR WLPLAQFVYN
TSQHASTGMA PAEALMGYRP DLKINVSKPP QPVAIHAASR AKHIEETRHK LIENLQKARQ
AQKIYYDAKH KPQQFKIGDY VMLNAKNLRL LRPVRKLDHK YVGPFKILNT IGKQAYKLEL
PPSYRNIHPV FHVSLLEPYN RRNGALPEPG PELVDGEEEY QVEEILEKRQ RKNKPPEYLV
RWTGWGPSGD TWEPEENILN TQAFEIFLEQ ENERQIQNQH TPKRQKRESQ VEKR
//
