ID A6RDH3_AJECN Unreviewed; 1091 AA.
AC A6RDH3;
DT 21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT 21-AUG-2007, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=Calcium permease family membrane transporter {ECO:0008006|Google:ProtNLM};
GN ORFNames=HCAG_07681 {ECO:0000313|EMBL:EDN11228.1};
OS Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus)
OS (Histoplasma capsulatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX NCBI_TaxID=2059318 {ECO:0000313|EMBL:EDN11228.1, ECO:0000313|Proteomes:UP000009297};
RN [1] {ECO:0000313|Proteomes:UP000009297}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NAm1 / WU24 {ECO:0000313|Proteomes:UP000009297};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC family. {ECO:0000256|ARBA:ARBA00008170}.
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DR EMBL; CH476663; EDN11228.1; -; Genomic_DNA.
DR AlphaFoldDB; A6RDH3; -.
DR STRING; 339724.A6RDH3; -.
DR VEuPathDB; FungiDB:HCAG_07681; -.
DR HOGENOM; CLU_001583_0_0_1; -.
DR OMA; PQWDMIT; -.
DR OrthoDB; 8346at2759; -.
DR Proteomes; UP000009297; Unassembled WGS sequence.
DR GO; GO:0005774; C:vacuolar membrane; IEA:UniProt.
DR GO; GO:0015369; F:calcium:proton antiporter activity; IEA:UniProt.
DR Gene3D; 1.20.1420.30; NCX, central ion-binding region; 1.
DR InterPro; IPR004713; CaH_exchang.
DR InterPro; IPR004837; NaCa_Exmemb.
DR InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR InterPro; IPR005185; YccF.
DR PANTHER; PTHR31503:SF10; CATION_H+ EXCHANGER PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR31503; VACUOLAR CALCIUM ION TRANSPORTER; 1.
DR Pfam; PF01699; Na_Ca_ex; 1.
DR Pfam; PF03733; YccF; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009297};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 284..310
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 429..457
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 518..537
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 549..569
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 638..658
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 874..891
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 944..963
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 984..1001
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1007..1026
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 282..333
FT /note="Inner membrane component"
FT /evidence="ECO:0000259|Pfam:PF03733"
FT DOMAIN 873..1025
FT /note="Sodium/calcium exchanger membrane region"
FT /evidence="ECO:0000259|Pfam:PF01699"
FT REGION 1..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 79..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 112..225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 676..720
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 740..772
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 811..844
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..33
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 79..98
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..199
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 696..720
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 740..765
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1091 AA; 121117 MW; 98DF3A2968814E99 CRC64;
MSSTKNNQDP QDPSLSSSAS KPSESNPIIE TEQDAQASPG KRLGRPRPAQ PQRRTTYGQR
PSINLKIFLS MANAFLGTMD SQDTGGRGSR TEGSSVTTYE PIRPAHISWR STERTAKKPP
TLRRTSTKPH RGQEFSVDDD PREYEEDNAL YKHPSMRSTA SLRRRGTHIQ QPMLERVDSR
DESGNDDIPS AESSNRLGDD RGEPSGLSSM SVDGDDDSHS DVSDAESFTL KDRQQAINET
HPFGIRIWKP ALYKKLRSVE KTAEGDIHSV PGERVSNWLY MANFLWSIIF GWWLALAALL
GALACFLLGF SPDSMAYGRV FSHLSLYLLY PFGSFVRLES DENYALEDEG EGRSISEYEQ
WQSGDLEHGR LFFGPISDRS LVGRRRNSID SASENDSLLG RTGRASREEN SLRIKKRFFG
RGEWTFGRVI FYTWFYFVIG PLMLLVSLVC WLMVFWIPMG RVTLILLHHL RRHPLALSFH
SDTTYTRSPS RPSSSILLCT YRAAGLKYWK YTIDGTNIFL INLLAVVLFT ILDYFVLNQM
LNVKSWITHS GLIFSLALMS IIPLAYFIGQ AVASISAQSS MGLGAAVNAF FSTVVEHELK
CMSCTSSGLG GPRDCRRCYF SEKPELQDRF FLKAVQPISW FAALLLFLSY VIGLWFTLRT
HAAIIWASEL DEKKPLHTPT HPHTPHLLPP DSDFSSGKAK QVTSANGPQH VSHGGTYQRS
GSIRDSQLYT RILGQSLKHV GLPSKSNDGS LEQPSTQTEN QNITPHLVPP KDHDNIAETL
CLPGLSEEQN ELFVRKVAEV AATAAAVAAR DVTTRQRRPP IASHASEHPH NKPVGVSSTA
HAEDVEEGGL LAETHVAEAG GHDAPNWSKM KSSVILLGAT LLYAIIAEIL VNTVDTVLNN
FDIDEKFLGI TLFALVPNST EFLNAISFAI NGNIALSMEI GSAYALQVCL LQIPALVLFS
AIYTQFIDKK DLLEHSFNLI FPQWDMITVI LCVFLLSYMY GEGKSNYFKG SILVLSYLFV
IAGFYLSDFN DINAMDVDPA DSLAMGQSAV FRTIGRTKGV SGFACRRKKG GGGQDFGLWL
GLVQGCFNMV S
//
