ID A6RDP5_AJECN Unreviewed; 993 AA.
AC A6RDP5;
DT 21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT 21-AUG-2007, sequence version 1.
DT 24-JAN-2024, entry version 84.
DE RecName: Full=AP-2 complex subunit alpha {ECO:0000256|PIRNR:PIRNR037091};
GN ORFNames=HCAG_07753 {ECO:0000313|EMBL:EDN11300.1};
OS Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus)
OS (Histoplasma capsulatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX NCBI_TaxID=2059318 {ECO:0000313|EMBL:EDN11300.1, ECO:0000313|Proteomes:UP000009297};
RN [1] {ECO:0000313|Proteomes:UP000009297}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NAm1 / WU24 {ECO:0000313|Proteomes:UP000009297};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
CC -!- FUNCTION: Adaptins are components of the adaptor complexes which link
CC clathrin to receptors in coated vesicles. Clathrin-associated protein
CC complexes are believed to interact with the cytoplasmic tails of
CC membrane proteins, leading to their selection and concentration.
CC {ECO:0000256|PIRNR:PIRNR037091}.
CC -!- SUBCELLULAR LOCATION: Membrane, coated pit
CC {ECO:0000256|ARBA:ARBA00004277}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004277}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004277}.
CC -!- SIMILARITY: Belongs to the adaptor complexes large subunit family.
CC {ECO:0000256|PIRNR:PIRNR037091}.
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DR EMBL; CH476663; EDN11300.1; -; Genomic_DNA.
DR AlphaFoldDB; A6RDP5; -.
DR STRING; 339724.A6RDP5; -.
DR VEuPathDB; FungiDB:HCAG_07753; -.
DR HOGENOM; CLU_003824_1_0_1; -.
DR OMA; PVLMHRY; -.
DR OrthoDB; 123661at2759; -.
DR Proteomes; UP000009297; Unassembled WGS sequence.
DR GO; GO:0030122; C:AP-2 adaptor complex; IEA:InterPro.
DR GO; GO:0035615; F:clathrin adaptor activity; IEA:InterPro.
DR GO; GO:0072583; P:clathrin-dependent endocytosis; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR Gene3D; 2.60.40.1230; -; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 3.30.310.10; TATA-Binding Protein; 1.
DR InterPro; IPR017104; AP2_complex_asu.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR002553; Clathrin/coatomer_adapt-like_N.
DR InterPro; IPR003164; Clathrin_a-adaptin_app_sub_C.
DR InterPro; IPR008152; Clathrin_a/b/g-adaptin_app_Ig.
DR InterPro; IPR013041; Clathrin_app_Ig-like_sf.
DR InterPro; IPR009028; Coatomer/calthrin_app_sub_C.
DR InterPro; IPR012295; TBP_dom_sf.
DR PANTHER; PTHR22780; ADAPTIN, ALPHA/GAMMA/EPSILON; 1.
DR PANTHER; PTHR22780:SF4; AP-2 COMPLEX SUBUNIT ALPHA; 1.
DR Pfam; PF01602; Adaptin_N; 1.
DR Pfam; PF02296; Alpha_adaptin_C; 1.
DR Pfam; PF02883; Alpha_adaptinC2; 1.
DR PIRSF; PIRSF037091; AP2_complex_alpha; 1.
DR SMART; SM00809; Alpha_adaptinC2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF49348; Clathrin adaptor appendage domain; 1.
DR SUPFAM; SSF55711; Subdomain of clathrin and coatomer appendage domain; 1.
PE 3: Inferred from homology;
KW Coated pit {ECO:0000256|ARBA:ARBA00023176, ECO:0000256|PIRNR:PIRNR037091};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583, ECO:0000256|PIRNR:PIRNR037091};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR037091};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|PIRNR:PIRNR037091};
KW Reference proteome {ECO:0000313|Proteomes:UP000009297};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR037091}.
FT TRANSMEM 947..972
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 695..806
FT /note="Clathrin adaptor alpha/beta/gamma-adaptin appendage
FT Ig-like subdomain"
FT /evidence="ECO:0000259|SMART:SM00809"
FT BINDING 5..6
FT /ligand="a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
FT inositol-3,4,5-trisphosphate)"
FT /ligand_id="ChEBI:CHEBI:57836"
FT /evidence="ECO:0000256|PIRSR:PIRSR037091-1"
FT BINDING 37
FT /ligand="a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
FT inositol-3,4,5-trisphosphate)"
FT /ligand_id="ChEBI:CHEBI:57836"
FT /evidence="ECO:0000256|PIRSR:PIRSR037091-1"
FT BINDING 46
FT /ligand="a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
FT inositol-3,4,5-trisphosphate)"
FT /ligand_id="ChEBI:CHEBI:57836"
FT /evidence="ECO:0000256|PIRSR:PIRSR037091-1"
FT BINDING 50..54
FT /ligand="a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
FT inositol-3,4,5-trisphosphate)"
FT /ligand_id="ChEBI:CHEBI:57836"
FT /evidence="ECO:0000256|PIRSR:PIRSR037091-1"
SQ SEQUENCE 993 AA; 112415 MW; DE91F8B8DC4ADA23 CRC64;
MSSMRGLVQF IADLRNARAR ELEEKRINKE LANIRQKFKD ANLNGYQKKK YVCKLLYVYI
QGYDIDFGHL EAVNLISANK YSEKQIGYLA VTLFLHEGHE LLHLVVNSIR KDLLDYNELN
NCLALHAVAN VGGREMGEAL GVDVHRLLIS PTSKAFVKKK AALTLLRLYR KHPGIVQPEW
AERIISLMDD PDMGVALSVL SLVMALVQDN PERYKGSYAK AAQRLKRIVV DNDIAQDYIY
YKVPCPWVQV KLLRLLQYYP PSDDTHVRHL IRQSIEEVMH SAMDTPKNAQ QNNAQNAVLF
EAINLLIHLD TEHNLMMKIS LRLGKFIQSR ETNVRYLGLE AMTHFAARAE TLDPIKHHQD
IILGSLRDRD ISVRRKGLDL LYSMCDTSNA RPIVNELLKY LQTADYSIRE EMVLKIAILT
EKYATDAQWY IDISLKLLSL AGDHVSDEVW QRVIQIVTNN EELQAYAAQH LLQYVKGDCH
DSLVKIGGYI LGEFGHLIAD NKGCSPIEQF LALQNKLNFC SDTTRALLLS SFIKFVNLFP
EIKPQLLRVF RIYSQSPDSE LQQRACEYLT LATLPTDDLL RTVCDEMPPF SERTSVLLSR
LHQKSAGISD KRTWVVGGKD ANADKQEVLL AQQTGLKRSF TTIVNGTSSG PKATVAKSTV
SSDLAGLDMS SSSDGPEPNL ASAAHLSADW EIGFNRLYFK DEGVLFEDAQ IQVGLRSEYR
VHLGVCKLYF TNKSSFPIGS FTTTLDNPSP QSIKIDSKNL PDPDVQAQSQ TQQTICFESK
GPFTKPPTIR ISYLAGALQA YTLQLPVLMH KYMDESTLSP DDFFKRWRQI GGPPLEAQST
FAVQGKGRMI TESFTRGIVQ GFRFRILGGV DPNSKNVVGC AVYQMDGGKT GCLLRLEPNY
EKKMYRITIR ATQDAVPQAL VKLMEERLAQ GVFYVDVHTT ALTNSYLFIR LALIFSLRFP
FLFPIPLFRF YVFTFRDLMI LQETHHGLLV RSQ
//
