ID A6REK5_AJECN Unreviewed; 1379 AA.
AC A6REK5;
DT 21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT 21-AUG-2007, sequence version 1.
DT 27-MAR-2024, entry version 85.
DE RecName: Full=Cytosolic regulator Pianissimo {ECO:0008006|Google:ProtNLM};
GN ORFNames=HCAG_08070 {ECO:0000313|EMBL:EDN04404.1};
OS Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus)
OS (Histoplasma capsulatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX NCBI_TaxID=2059318 {ECO:0000313|EMBL:EDN04404.1, ECO:0000313|Proteomes:UP000009297};
RN [1] {ECO:0000313|Proteomes:UP000009297}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NAm1 / WU24 {ECO:0000313|Proteomes:UP000009297};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
CC -!- SIMILARITY: Belongs to the RICTOR family.
CC {ECO:0000256|ARBA:ARBA00008878}.
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DR EMBL; CH476664; EDN04404.1; -; Genomic_DNA.
DR STRING; 339724.A6REK5; -.
DR VEuPathDB; FungiDB:HCAG_08070; -.
DR HOGENOM; CLU_001013_1_1_1; -.
DR OMA; EIRIHAT; -.
DR OrthoDB; 90320at2759; -.
DR Proteomes; UP000009297; Unassembled WGS sequence.
DR GO; GO:0031932; C:TORC2 complex; IEA:InterPro.
DR GO; GO:0031929; P:TOR signaling; IEA:InterPro.
DR CDD; cd11627; HR1_Ste20-like; 1.
DR Gene3D; 1.10.287.160; HR1 repeat; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011072; HR1_rho-bd.
DR InterPro; IPR036274; HR1_rpt_sf.
DR InterPro; IPR028268; Pianissimo_fam.
DR InterPro; IPR028267; Pianissimo_N.
DR InterPro; IPR029453; Rictor_IV.
DR InterPro; IPR029451; RICTOR_M.
DR InterPro; IPR029452; RICTOR_V.
DR PANTHER; PTHR13298; CYTOSOLIC REGULATOR PIANISSIMO; 1.
DR PANTHER; PTHR13298:SF11; RAPAMYCIN-INSENSITIVE COMPANION OF MTOR; 1.
DR Pfam; PF02185; HR1; 1.
DR Pfam; PF14663; RasGEF_N_2; 1.
DR Pfam; PF14666; RICTOR_M; 1.
DR Pfam; PF14664; RICTOR_N; 1.
DR Pfam; PF14668; RICTOR_V; 1.
DR SMART; SM00742; Hr1; 1.
DR SMART; SM01303; RasGEF_N_2; 1.
DR SMART; SM01307; RICTOR_M; 1.
DR SMART; SM01308; RICTOR_N; 1.
DR SMART; SM01310; RICTOR_V; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF46585; HR1 repeat; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000009297}.
FT DOMAIN 142..211
FT /note="REM-1"
FT /evidence="ECO:0000259|SMART:SM00742"
FT DOMAIN 274..638
FT /note="Rapamycin-insensitive companion of mTOR N-terminal"
FT /evidence="ECO:0000259|SMART:SM01308"
FT DOMAIN 717..941
FT /note="Rapamycin-insensitive companion of mTOR middle"
FT /evidence="ECO:0000259|SMART:SM01307"
FT DOMAIN 1125..1197
FT /note="Rapamycin-insensitive companion of mTOR"
FT /evidence="ECO:0000259|SMART:SM01310"
FT REGION 1..124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 216..251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..115
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 216..233
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1379 AA; 152975 MW; 5CF9D307AFAE89E6 CRC64;
MASNYDPASS ATPTQRRVLS GGTPFSSQED VSTDGSWHDA ASKSSGNRIG SNPAPTAASS
NSSSCSSSNN NNSSNNINNT NNFGPWSASF APSGPPPGSF SSDLKSIGST RGPTTSTPRP
EPPFLSRIIA IDGVDVLTRA EQRQAVLRGK IAKELKMKSG TENMLEALLV KNLKQTKEQR
LRVESELSSS NMKLAQLRHE LEEEILRAQA QSSPTAGRLS TLFRGTPLRS PSRASQGGDV
GMGSGDAETE SPTYVLAETL QELETTDMPS DYYVERANNL VDLFKRHPTL KYDLAWQVFG
LRVQTMLLSD SRDVVAAGYR LTRHAIADRR SIQIIRSFHT DEMVMMSLVK ETKATIEREQ
ALKFVRAFLD VKDGVRELSR GVVRTLVSIA DHRDDRLRNI CIMTLAEILV KDPGLLFSAG
GIGVLNDALG EGVYGASESL AAGFIHILDT PRNRIYLRAG CELEGVFAAF TDPLGDGNHH
ARLKSSAKTI SSMLKTWPGL LTLLCNKEKP LQSLLNSLQY PEPLARDLIL ELLFDALRIK
PPSWSSSFLA GRRLTTYGRV TNLRSESDTK HLRAFDEHEN NSFDLTTHFS ALVLAVLIEA
GLITALSNLI EDEPDLSLKR KGTLLLTEVL KLAHHSLPQS MSAKLQVLPQ LLPCSTPRDA
GTYHVSTSTV YQMESINRTL TRSDGMQSSR GKYTVHTDIS ASLLTTEQGK SKLSASMDEG
QFRTAILDTH VLSSVNFMKW KWDLIHNIIE GPLTNPKRLD EAIRGSKFMK RLMGFYRPFK
SRFSMIRNTK PNQRYVRTGC ALMRTLLQTP EGTKYLAENK LLRQIAECLA QVDRMSGLTS
SSPVFSRNNM NETLSGGYFA LLGVLSSEPS GLQMMERWHM HNMFYHIIEL KDRNDLIQTL
LGNMDFSLES HLRIILSKAL TTGSKDIRIF ATKLLRKYVV GSVSFPAPMV DIGNGEWVVK
LLVTQLYDPE VAVCQVAVKI LEEACNQRSC LEYVVKCRPS LDHLGEIGAP LLLRFLSTSV
GYHYLDGLDY ITQEMDDWFL GRNDAYVGLV EASLTRAYVD QPRRNSFAFD DIVEMQDIGL
VPPHFYRELA RTHEGCKLLE QSGHFNEFAH TIRDFRLDEE DPEVLLKVKG CLWAVGNVGS
MDLSAPFLEE TEIVGAIGKI AENAGVMTMR GTAFFVLGLI SRSLHGMEML LEAGWDAAVD
QKGRSLGSCI PVQLSRLYSV SFPTYEPNID EERAEKERFK ASATDSDPVC QKILDLIIDM
GNTVLSKRAA SDLNTLRTKK PEYFRQIPLF QKTLILLESH HFRLPARRFA LDLFDRSVLR
LIVRGDWDGD GDGGNVDIDA YADIDVDISI DGDVDIDVDR ADGVPASNLQ PDADTSMGN
//
