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Database: UniProt
Entry: A6RF15_AJECN
LinkDB: A6RF15_AJECN
Original site: A6RF15_AJECN 
ID   A6RF15_AJECN            Unreviewed;       569 AA.
AC   A6RF15;
DT   21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT   21-AUG-2007, sequence version 1.
DT   24-JAN-2024, entry version 60.
DE   RecName: Full=Enhancer of polycomb-like protein {ECO:0000256|RuleBase:RU361124};
GN   ORFNames=HCAG_08230 {ECO:0000313|EMBL:EDN04564.1};
OS   Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus)
OS   (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX   NCBI_TaxID=2059318 {ECO:0000313|EMBL:EDN04564.1, ECO:0000313|Proteomes:UP000009297};
RN   [1] {ECO:0000313|Proteomes:UP000009297}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NAm1 / WU24 {ECO:0000313|Proteomes:UP000009297};
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
CC   -!- FUNCTION: Component of the NuA4 histone acetyltransferase complex which
CC       is involved in transcriptional activation of selected genes principally
CC       by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is
CC       also involved in DNA repair. Involved in gene silencing by neighboring
CC       heterochromatin, blockage of the silencing spreading along the
CC       chromosome, and required for cell cycle progression through G2/M.
CC       {ECO:0000256|ARBA:ARBA00025513}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|RuleBase:RU361124}.
CC   -!- SIMILARITY: Belongs to the enhancer of polycomb family.
CC       {ECO:0000256|ARBA:ARBA00008035, ECO:0000256|RuleBase:RU361124}.
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DR   EMBL; CH476664; EDN04564.1; -; Genomic_DNA.
DR   AlphaFoldDB; A6RF15; -.
DR   STRING; 339724.A6RF15; -.
DR   VEuPathDB; FungiDB:HCAG_08230; -.
DR   HOGENOM; CLU_010580_1_0_1; -.
DR   OMA; HIKWNEG; -.
DR   OrthoDB; 1343374at2759; -.
DR   Proteomes; UP000009297; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0032777; C:Piccolo NuA4 histone acetyltransferase complex; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR024943; Enhancer_polycomb.
DR   InterPro; IPR019542; Enhancer_polycomb-like_N.
DR   PANTHER; PTHR14898; ENHANCER OF POLYCOMB; 1.
DR   PANTHER; PTHR14898:SF0; ENHANCER OF POLYCOMB-LIKE PROTEIN; 1.
DR   Pfam; PF10513; EPL1; 1.
PE   3: Inferred from homology;
KW   Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU361124};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009297};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163,
KW   ECO:0000256|RuleBase:RU361124};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW   ECO:0000256|RuleBase:RU361124}.
FT   DOMAIN          7..147
FT                   /note="Enhancer of polycomb-like N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF10513"
FT   REGION          298..340
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          542..569
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          240..267
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        544..569
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   569 AA;  65181 MW;  DDC12A94A02A6AAB CRC64;
     MMRSTRPKKL TSKQPIPIFR EDQIDIIEDD LQTTLQAIDT GVEKAEETEY HLQAAINAAA
     RGNIAQAHIP TPETVTSSIK YDTLYKPTFS QPATYIRFSS TVEDCSGCSY NLVEEDDVAL
     KIMNQKKGAS TQCTEDQFEE FMAFFEETAQ TKQPFASVDS PPVLSYSEME HCFDGLVDEN
     ARRFARDIYE HWKSRRTKCV NRPLQTGLKF ETGQETDDGD PYVCFRRREV RQIRKTRGRD
     AQSAEKLRRL RKELEEAREL VAMVRQRELA RKELLVAERQ VFVQRAEVKE MKRKLGIKDD
     DDDLVNQRQP KKRPPEVPAS SRPGATQLRM PPRPSGQPGE DLVLLEDVQA DKESEVLREI
     KQNIAKHSKW NEGYVDWTTA PLTPTSDHSF DAEFRPAITT EYLPTPPASE SSDHSRDALE
     ELSRFDALTK FARTVQQCIP SDEESSRNMP SFRRRIGRGG RMMIDRRNLP FRNKSEADPI
     KLERFKYDQD DEDMDPIYEM DEFDIQIMQH RAYLSAKSRD QAAAQAQFQA HVQAQRRLQG
     ETPVMAGPNN SHNGTNNVVL KGPAAQTPS
//
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