ID A6RF15_AJECN Unreviewed; 569 AA.
AC A6RF15;
DT 21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT 21-AUG-2007, sequence version 1.
DT 24-JAN-2024, entry version 60.
DE RecName: Full=Enhancer of polycomb-like protein {ECO:0000256|RuleBase:RU361124};
GN ORFNames=HCAG_08230 {ECO:0000313|EMBL:EDN04564.1};
OS Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus)
OS (Histoplasma capsulatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX NCBI_TaxID=2059318 {ECO:0000313|EMBL:EDN04564.1, ECO:0000313|Proteomes:UP000009297};
RN [1] {ECO:0000313|Proteomes:UP000009297}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NAm1 / WU24 {ECO:0000313|Proteomes:UP000009297};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
CC -!- FUNCTION: Component of the NuA4 histone acetyltransferase complex which
CC is involved in transcriptional activation of selected genes principally
CC by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is
CC also involved in DNA repair. Involved in gene silencing by neighboring
CC heterochromatin, blockage of the silencing spreading along the
CC chromosome, and required for cell cycle progression through G2/M.
CC {ECO:0000256|ARBA:ARBA00025513}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU361124}.
CC -!- SIMILARITY: Belongs to the enhancer of polycomb family.
CC {ECO:0000256|ARBA:ARBA00008035, ECO:0000256|RuleBase:RU361124}.
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DR EMBL; CH476664; EDN04564.1; -; Genomic_DNA.
DR AlphaFoldDB; A6RF15; -.
DR STRING; 339724.A6RF15; -.
DR VEuPathDB; FungiDB:HCAG_08230; -.
DR HOGENOM; CLU_010580_1_0_1; -.
DR OMA; HIKWNEG; -.
DR OrthoDB; 1343374at2759; -.
DR Proteomes; UP000009297; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0032777; C:Piccolo NuA4 histone acetyltransferase complex; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR024943; Enhancer_polycomb.
DR InterPro; IPR019542; Enhancer_polycomb-like_N.
DR PANTHER; PTHR14898; ENHANCER OF POLYCOMB; 1.
DR PANTHER; PTHR14898:SF0; ENHANCER OF POLYCOMB-LIKE PROTEIN; 1.
DR Pfam; PF10513; EPL1; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU361124};
KW Reference proteome {ECO:0000313|Proteomes:UP000009297};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU361124};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU361124}.
FT DOMAIN 7..147
FT /note="Enhancer of polycomb-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF10513"
FT REGION 298..340
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 542..569
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 240..267
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 544..569
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 569 AA; 65181 MW; DDC12A94A02A6AAB CRC64;
MMRSTRPKKL TSKQPIPIFR EDQIDIIEDD LQTTLQAIDT GVEKAEETEY HLQAAINAAA
RGNIAQAHIP TPETVTSSIK YDTLYKPTFS QPATYIRFSS TVEDCSGCSY NLVEEDDVAL
KIMNQKKGAS TQCTEDQFEE FMAFFEETAQ TKQPFASVDS PPVLSYSEME HCFDGLVDEN
ARRFARDIYE HWKSRRTKCV NRPLQTGLKF ETGQETDDGD PYVCFRRREV RQIRKTRGRD
AQSAEKLRRL RKELEEAREL VAMVRQRELA RKELLVAERQ VFVQRAEVKE MKRKLGIKDD
DDDLVNQRQP KKRPPEVPAS SRPGATQLRM PPRPSGQPGE DLVLLEDVQA DKESEVLREI
KQNIAKHSKW NEGYVDWTTA PLTPTSDHSF DAEFRPAITT EYLPTPPASE SSDHSRDALE
ELSRFDALTK FARTVQQCIP SDEESSRNMP SFRRRIGRGG RMMIDRRNLP FRNKSEADPI
KLERFKYDQD DEDMDPIYEM DEFDIQIMQH RAYLSAKSRD QAAAQAQFQA HVQAQRRLQG
ETPVMAGPNN SHNGTNNVVL KGPAAQTPS
//