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Database: UniProt
Entry: A6RGC3_AJECN
LinkDB: A6RGC3_AJECN
Original site: A6RGC3_AJECN 
ID   A6RGC3_AJECN            Unreviewed;       797 AA.
AC   A6RGC3;
DT   21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT   21-AUG-2007, sequence version 1.
DT   08-MAY-2019, entry version 67.
DE   SubName: Full=Phosphoribosylformylglycinamidine cyclo-ligase {ECO:0000313|EMBL:EDN05035.1};
GN   ORFNames=HCAG_08689 {ECO:0000313|EMBL:EDN05035.1};
OS   Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus)
OS   (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX   NCBI_TaxID=339724 {ECO:0000313|EMBL:EDN05035.1, ECO:0000313|Proteomes:UP000009297};
RN   [1] {ECO:0000313|Proteomes:UP000009297}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NAm1 / WU24 {ECO:0000313|Proteomes:UP000009297};
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J.,
RA   Wortman J.R., Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E.,
RA   Zeng Q., Hung C.-Y., McMahan C., Muszewska A., Grynberg M.,
RA   Mandel M.A., Kellner E.M., Barker B.M., Galgiani J.N., Orbach M.J.,
RA   Kirkland T.N., Cole G.T., Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens
RT   Coccidioides and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
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DR   EMBL; CH476666; EDN05035.1; -; Genomic_DNA.
DR   RefSeq; XP_001536368.1; XM_001536318.1.
DR   EnsemblFungi; EDN05035; EDN05035; HCAG_08689.
DR   GeneID; 5442634; -.
DR   KEGG; aje:HCAG_08689; -.
DR   EuPathDB; FungiDB:HCAG_08689; -.
DR   eggNOG; KOG0237; Eukaryota.
DR   eggNOG; COG0150; LUCA.
DR   eggNOG; COG0151; LUCA.
DR   KO; K11788; -.
DR   OrthoDB; 105366at2759; -.
DR   Proteomes; UP000009297; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0004637; F:phosphoribosylamine-glycine ligase activity; IEA:InterPro.
DR   GO; GO:0004641; F:phosphoribosylformylglycinamidine cyclo-ligase activity; IEA:InterPro.
DR   GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:InterPro.
DR   GO; GO:0009113; P:purine nucleobase biosynthetic process; IEA:InterPro.
DR   CDD; cd02196; PurM; 1.
DR   Gene3D; 3.30.1330.10; -; 1.
DR   Gene3D; 3.30.1490.20; -; 1.
DR   Gene3D; 3.90.600.10; -; 1.
DR   Gene3D; 3.90.650.10; -; 1.
DR   HAMAP; MF_00741; AIRS; 1.
DR   HAMAP; MF_00138; GARS; 1.
DR   InterPro; IPR011761; ATP-grasp.
DR   InterPro; IPR013815; ATP_grasp_subdomain_1.
DR   InterPro; IPR016185; PreATP-grasp_dom_sf.
DR   InterPro; IPR020561; PRibGlycinamid_synth_ATP-grasp.
DR   InterPro; IPR000115; PRibGlycinamide_synth.
DR   InterPro; IPR020560; PRibGlycinamide_synth_C-dom.
DR   InterPro; IPR037123; PRibGlycinamide_synth_C_sf.
DR   InterPro; IPR020562; PRibGlycinamide_synth_N.
DR   InterPro; IPR010918; PurM-like_C_dom.
DR   InterPro; IPR036676; PurM-like_C_sf.
DR   InterPro; IPR016188; PurM-like_N.
DR   InterPro; IPR036921; PurM-like_N_sf.
DR   InterPro; IPR004733; PurM_cligase.
DR   InterPro; IPR011054; Rudment_hybrid_motif.
DR   PANTHER; PTHR10520; PTHR10520; 1.
DR   Pfam; PF00586; AIRS; 1.
DR   Pfam; PF02769; AIRS_C; 1.
DR   Pfam; PF01071; GARS_A; 1.
DR   Pfam; PF02843; GARS_C; 1.
DR   Pfam; PF02844; GARS_N; 1.
DR   SMART; SM01210; GARS_C; 1.
DR   SUPFAM; SSF51246; SSF51246; 1.
DR   SUPFAM; SSF52440; SSF52440; 1.
DR   SUPFAM; SSF55326; SSF55326; 1.
DR   SUPFAM; SSF56042; SSF56042; 1.
DR   TIGRFAMs; TIGR00877; purD; 1.
DR   TIGRFAMs; TIGR00878; purM; 1.
DR   PROSITE; PS50975; ATP_GRASP; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00409};
KW   Complete proteome {ECO:0000313|Proteomes:UP000009297};
KW   Ligase {ECO:0000313|EMBL:EDN05035.1};
KW   Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00409};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009297}.
FT   DOMAIN      115    323       ATP-grasp. {ECO:0000259|PROSITE:PS50975}.
SQ   SEQUENCE   797 AA;  83902 MW;  B308ABB204DFE842 CRC64;
     MLQERLRVLV VGSGGREHAF AWKLSHSPSV DIVFVAPGNG GTASSHSKIA NIDIKADDYA
     GLVTFSQKNN VNLVVPGPEA PLVDGIQKFF QSVGIRCFGP SQAAARMEGS KTFSKDFMKR
     HNIPTAAYEN FSDYASASRY LDSVNHDVVI KASGLAAGKG VIIPQSKEEA QKALREMMLD
     RQFGEAGDEV VIEEFLEGDE LSILTFSDGY TVRSLPPAQD HKRIFDGDQG PNTGGMGCYA
     PTRITSKEVL DEIDKTVIIP TISGMRREGF PFVGILFTGL MMTKNGPKVL EYNVRGGDPE
     TQTLLPLLSD DTDLAEVMIA CTEHWLDGVT IKIEPKFSAT VIAVAEGYPG SYAKGRDISL
     TPPPAANTLI FHAGTTLTNN HLKTSGGRVI AATSTAATLE DAVSDAYAGI STVNFQGMHY
     RKDIAHRAFR STSASNAEPL TYAAAGVSID AGNDLVKQIK ANVAQTRRPG TDAIIGGFGG
     TFSLSTCNSG FHPSSPTLIG AIDGVGTKLA IAHEMRVHNT VGMDLVAMNV NDLVVQGAEP
     LFFLDCYSCG KLDVATAAAF VSGVAAGCVD AGCALIGGET AEMPGLYAGT AYDAVGAAVG
     AIDTAKRTVL PDIERMQVGD VLLGLASSGP HSNGYSLVRK VVERSGLSYH DAAPFETAAP
     SLGAALLTPT RIYVKPLLAA LAAAPGAIKG LAHITGGGLV ENIPRALPKY LTALVDVASW
     PLPPVFRWLK KAGGITGSEM GRAFNNGIGM VIVVEKEDVA LVKGLLEGKG EKVFVVGELV
     ARGEDEGCVL KSLESWE
//
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