ID A6RGV4_AJECN Unreviewed; 1384 AA.
AC A6RGV4;
DT 21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT 21-AUG-2007, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=RRM domain-containing protein {ECO:0000259|PROSITE:PS50102};
GN ORFNames=HCAG_08871 {ECO:0000313|EMBL:EDN05221.1};
OS Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus)
OS (Histoplasma capsulatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX NCBI_TaxID=2059318 {ECO:0000313|EMBL:EDN05221.1, ECO:0000313|Proteomes:UP000009297};
RN [1] {ECO:0000313|Proteomes:UP000009297}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NAm1 / WU24 {ECO:0000313|Proteomes:UP000009297};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
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DR EMBL; CH476667; EDN05221.1; -; Genomic_DNA.
DR STRING; 339724.A6RGV4; -.
DR VEuPathDB; FungiDB:HCAG_08871; -.
DR HOGENOM; CLU_003925_0_0_1; -.
DR OMA; LWARYIL; -.
DR OrthoDB; 3035286at2759; -.
DR Proteomes; UP000009297; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR CDD; cd12296; RRM1_Prp24; 1.
DR CDD; cd12299; RRM4_Prp24; 1.
DR CDD; cd00590; RRM_SF; 1.
DR Gene3D; 3.30.70.330; -; 4.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR InterPro; IPR003107; HAT.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR034397; Prp24_RRM1.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR031766; RRM_occluded.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR48025; OS02G0815200 PROTEIN; 1.
DR PANTHER; PTHR48025:SF22; OS02G0815200 PROTEIN; 1.
DR Pfam; PF00076; RRM_1; 3.
DR Pfam; PF16842; RRM_occluded; 1.
DR SMART; SM00386; HAT; 2.
DR SMART; SM00360; RRM; 4.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 4.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50102; RRM; 4.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000009297};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00176}.
FT DOMAIN 859..933
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 934..1007
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 1036..1112
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 1165..1238
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 1..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 85..116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 146..177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 812..858
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1127..1162
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1259..1384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..54
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 85..112
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 146..167
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 820..858
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1136..1155
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1361..1384
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1384 AA; 153336 MW; 2F8A21FAD62658D5 CRC64;
MDIISLLSPQ DSPSGKSTPA AASTRAAATA SSGSAPTFAP TPSPVSAASA SASPHHNHHK
SRQNSGRAGM TSSPLVHQIL NHTQLRDPSP QDLTQGNGTR TPPSSELQPA RKSSTPGIDA
LADLASMQRP QPHRANPPIR RNASTEIHES QMSPSTLNPT VNPIPRNHST PRPHFDVSEG
LKEANRRDFS NSSLTPNMQQ MASELYAHIQ QNRHAYESRV KFIRLLHQGF VEHVYPPSSP
DSRGDPHTYD VLPELRAARE ELDHLFAIGE DLWAEWIQDE SVLARSVDEQ VGVMELCRRS
VDEEYGSTKL WIIYGEWMLY LYNSASQPGD TPVSRQWSEE DRIVAQKTFT WQSVVDVWMN
AAEATNWRIN DSHLVWDRYL EIVVQDVGKQ PSPDKLAHAR DLFVNRLQVP HMTWDQTFQL
FSNFVSTYYN NHYEETMVDM TNRAAHAKAL WNAREVREVE LRRSAEAGDS GTEWSLFVAY
IEWELNQNRR KNQYSFDLIC ALYQRVVLRF PTDVGFWEDY IMFIVEASMN GGPHSHYIPA
LPSLERATRH CPWSGTLWSQ RILSAERAGL SFTQIADIKH KATRTGLLDT GGINEVIKVH
TTWCSYLRRR AFQPDSTDED LDVAEVGIRS AIESIQELGE KDNKAVPNDP LFRLERIYIR
YLSESGSWDS ARETFKGLVA RHGHSYEFWM MYYTWELLCW SKFTQSDDSA SASRRTPNPS
LATAVLKQAL QRTDLDWPEK IMSTYIDHCE HYEDADELQI AVVGFRKAMK ALTKRREEEA
LQAAAHQSAA AAAITSTGPS ADVPAMSAMG TGLEVENETT PQGSKRKRRV EEVDVNGSAS
KKAKADDDGT PPKRDRENAT VIVENLPSGV TETRVRQFFR DCGKINSLKL LSRNGNQPRA
IVEFDTREDA LAAQTRDQRT FEDQTISVHV GTNTTLFVTN FAPTADEAYV RDLFSPYGEV
VDIRFPSLKY NTHRRFCYVQ FQTAIAAHAA TELNGTQQEV VGDLAGSAGS MKLPLVVKIS
DPTKRQERTG PTEEGREIHV SNLDWKATED DLVELFAAYG QVEAARIPRK ANGASKGFGF
VVFQAKESAE ASLAMNEQLF RSRPLHVHIS TPTAAKRQAA TILSRVGAGG RSKSPSMEPN
GASPSSSAPH ASDQPDSNPS DKHLRTLALM NIPDTVNDTR ISAIVSPYGA LVKLILRPDH
QGAIVEFLDV NDAGRASLGL DGYEIAPGRR IRVGSVGEML RMPAERRVDR ILVGKEREQE
KRMKEMEMES DALSVSAPGA AGKSKMVMMK QSAAPIRRPA QPGGGVRSGR RGGLGVKRGG
ASAATGVGSG QQHAPAQASP LTAEIAPAKK SNDDFRAMLE SSKSRSQGQE GGQAQGQDGR
EPQQ
//
