ID   A6RGZ6_AJECN            Unreviewed;      1307 AA.
AC   A6RGZ6;
DT   21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT   21-AUG-2007, sequence version 1.
DT   27-MAR-2024, entry version 74.
DE   RecName: Full=Reverse transcriptase domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=HCAG_08913 {ECO:0000313|EMBL:EDN05263.1};
OS   Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus)
OS   (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX   NCBI_TaxID=2059318 {ECO:0000313|EMBL:EDN05263.1, ECO:0000313|Proteomes:UP000009297};
RN   [1] {ECO:0000313|Proteomes:UP000009297}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NAm1 / WU24 {ECO:0000313|Proteomes:UP000009297};
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CH476667; EDN05263.1; -; Genomic_DNA.
DR   VEuPathDB; FungiDB:HCAG_08913; -.
DR   HOGENOM; CLU_000680_23_1_1; -.
DR   OMA; VECIENW; -.
DR   OrthoDB; 2202746at2759; -.
DR   Proteomes; UP000009297; Unassembled WGS sequence.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd01650; RT_nLTR_like; 1.
DR   Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR   Gene3D; 4.10.60.10; Zinc finger, CCHC-type; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR   InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR   InterPro; IPR000477; RT_dom.
DR   InterPro; IPR001878; Znf_CCHC.
DR   InterPro; IPR036875; Znf_CCHC_sf.
DR   PANTHER; PTHR33481; REVERSE TRANSCRIPTASE; 1.
DR   PANTHER; PTHR33481:SF1; REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF14529; Exo_endo_phos_2; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SMART; SM00343; ZnF_C2HC; 2.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF56219; DNase I-like; 1.
DR   SUPFAM; SSF57756; Retrovirus zinc finger-like domains; 1.
DR   PROSITE; PS50878; RT_POL; 1.
DR   PROSITE; PS50158; ZF_CCHC; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00047};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009297};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00047};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00047}.
FT   DOMAIN          298..314
FT                   /note="CCHC-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50158"
FT   DOMAIN          851..1115
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1269..1307
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        9..23
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1307 AA;  144562 MW;  442A88EEDADA006C CRC64;
     MVVMEEIVGR ADGRPREENS DKRQQPTTCG AILTQLSNVL CNGSEDPAIN GKGKEVVEEA
     ARLVRELKVK LGEVMLAKVE DATVATRVQR QPEGVKEAKL SSWAKVAGQG IPEKPVPNRT
     LREITVLRRD CEALPAEEAT PPAIVAAVNA RIVDVTKGKV LAARCLPSGD IILTTDARET
     REALTKSSTW LEVLGQKAKA KHTLYPVMVK GVPMGNTNWK EEQQAIKAIY AQNEGLRRGV
     QIERLSLRRN ASLQAKVGSL VLSVTSPQQA NLLVDNGLII DSIFCDVEIF HREAQVTRCF
     NCHEYGHTAR FCRQAKRCGF CAAKEHDDKE CPARKAGEQP STTELTTWVS AAGGPNGLHA
     DPSPHATMRD TLNLLQYNVH NSARVMGALL ADPATEDKYD VIAVQEPSRN PHMLATHCPR
     SCGFWPAYHP ETRPRVCFLV NKRLVEHTWE CHYHSEYIAV LTITTDLGKV QIVNVYAPPP
     GGYSSEPEES TIGQLQEVAG MGTDAELVIL GDLNVHHERW GGVRVERNFR MAWQLIAQVD
     RLGLQLATPV GATTWQDRGS PGTTIDLTFL SPLLHDKLRR CAIAEEACKG SDHKPIETTL
     ELTPIPKEAE RRNWKNAEPE EVARDCQKLY VPQSLDSRQA VKEYADYLVG FVGTLADKHA
     TVSKAGLKSK TWWSPRVAKA VEEYKQARRS QLPEMERLRA RCKRNREIHL AKTANFRDLV
     DRTRDDPRLM WGLAKWGKER SHLPPQAPTV PPLRTGEGAD ATVETSFEGK AEALRQRFFP
     QPEPADLSDT NMELLQAERE ASNDTISVED MESLIQRLPN RKAPGRSGIT NEFLKMLGRT
     FVEAITALTN ACWHWETYPD TFKEAKTVAL RKPGKADYQT AGAWRPIALL DTIGKIVEAA
     TAKRLRKIAE DHNLLPSQQM GARRGRSTET AIAQLLAQIR TVWQHPGQVA SVLSLDMTGA
     YDKVLRERMV HILRRLGIPR DLVGWVASFM TNRKSTIAFE GQESDTFDIP AGIPQGSPLS
     PILFLFYNEE LVRICSRPGR PVVCIAFVDD VNVMAYGQST EDNCRELLRM HRACEEWAAR
     HGAVFAPQKY ELMHFTRARN QFNLQAELRL PGQTIQPKQV MRVLGVWLDS RLRWKGHLDA
     VAGKMKTQVR ALSQTTQSTW GLPLQQARMV YNMVIRPALT YGAIAWHQPQ GQGGTGPAKS
     GLALKLTTVQ NSCLRIVAGA YKRTPTSTLE AETHTVPLDI HLDGLVAKAV NRMKASGMAQ
     QIENACAAHK DQASAPGGDK GGTETHGSCG SPGSPASGLG TAMDSGC
//