ID A6T241_JANMA Unreviewed; 338 AA.
AC A6T241;
DT 21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT 21-AUG-2007, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE RecName: Full=DNA polymerase III subunit delta {ECO:0000256|ARBA:ARBA00017703};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN Name=holA {ECO:0000313|EMBL:ABR89038.1};
GN OrderedLocusNames=mma_2898 {ECO:0000313|EMBL:ABR89038.1};
OS Janthinobacterium sp. (strain Marseille) (Minibacterium massiliensis).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Oxalobacteraceae; Janthinobacterium.
OX NCBI_TaxID=375286 {ECO:0000313|EMBL:ABR89038.1, ECO:0000313|Proteomes:UP000006388};
RN [1] {ECO:0000313|EMBL:ABR89038.1, ECO:0000313|Proteomes:UP000006388}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Marseille {ECO:0000313|EMBL:ABR89038.1,
RC ECO:0000313|Proteomes:UP000006388};
RX PubMed=17722982; DOI=10.1371/journal.pgen.0030138;
RA Audic S., Robert C., Campagna B., Parinello H., Claverie J.-M., Raoult D.,
RA Drancourt M.;
RT "Genome analysis of Minibacterium massiliensis highlights the convergent
RT evolution of water-living bacteria.";
RL PLoS Genet. 3:1454-1463(2007).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SIMILARITY: Belongs to the DNA polymerase HolA subunit family.
CC {ECO:0000256|ARBA:ARBA00034754}.
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DR EMBL; CP000269; ABR89038.1; -; Genomic_DNA.
DR RefSeq; WP_012080747.1; NC_009659.1.
DR AlphaFoldDB; A6T241; -.
DR STRING; 375286.mma_2898; -.
DR KEGG; mms:mma_2898; -.
DR eggNOG; COG1466; Bacteria.
DR HOGENOM; CLU_044694_0_0_4; -.
DR OrthoDB; 9770982at2; -.
DR Proteomes; UP000006388; Chromosome.
DR GO; GO:0009360; C:DNA polymerase III complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR CDD; cd18138; HLD_clamp_pol_III_delta; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 1.20.272.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR008921; DNA_pol3_clamp-load_cplx_C.
DR InterPro; IPR032780; DNA_pol3_delt_C.
DR InterPro; IPR010372; DNA_pol3_delta_N.
DR InterPro; IPR005790; DNA_polIII_delta.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01128; holA; 1.
DR PANTHER; PTHR34388; DNA POLYMERASE III SUBUNIT DELTA; 1.
DR PANTHER; PTHR34388:SF1; DNA POLYMERASE III SUBUNIT DELTA; 1.
DR Pfam; PF14840; DNA_pol3_delt_C; 1.
DR Pfam; PF06144; DNA_pol3_delta; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48019; post-AAA+ oligomerization domain-like; 1.
PE 3: Inferred from homology;
KW Nucleotidyltransferase {ECO:0000313|EMBL:ABR89038.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006388};
KW Transferase {ECO:0000313|EMBL:ABR89038.1}.
FT DOMAIN 20..189
FT /note="DNA polymerase III delta N-terminal"
FT /evidence="ECO:0000259|Pfam:PF06144"
FT DOMAIN 215..313
FT /note="DNA polymerase III subunit delta C-terminal"
FT /evidence="ECO:0000259|Pfam:PF14840"
SQ SEQUENCE 338 AA; 37494 MW; 1EAA6935B0486E27 CRC64;
MQLRIDALDA HLNKPLAGLY VITSDEHLLA LEAADKIRKA ARAQAYSERE VLVVDRSFKW
GELLAANQSQ SLFGDKKLIE LRIPTGKPGK DGGKALQDYA ASLSPDNVTL ITLPKLDWAT
QKAAWVTSLQ QASVYIDIPL IERAQLPAWL GVRLAAQRQS ANRECLDFIA DRVEGNLLAA
HQEIQKLALL YPEGPLSFEQ IHDAVLNVAR YDVFKLNEAM LSGDTTRLVR MLEGLKGEGE
ALPLVLWAVA EEVRTLLKLK AGVAQGRPLS QLTKEYRIWG PRERLVEPAL RRLKLATLED
ALQEAAQIDK MVKGLRAKQF SGDAWDAMLQ LGLKIARG
//
