ID MUTS_STAA2 Reviewed; 872 AA.
AC A6U1B4;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 1.
DT 27-MAR-2024, entry version 90.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN OrderedLocusNames=SaurJH1_1381;
OS Staphylococcus aureus (strain JH1).
OC Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=359787;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JH1;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA Hauser L., Kyrpides N., Ivanova N., Tomasz A., Richardson P.;
RT "Complete sequence of chromosome of Staphylococcus aureus subsp. aureus
RT JH1.";
RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR EMBL; CP000736; ABR52232.1; -; Genomic_DNA.
DR AlphaFoldDB; A6U1B4; -.
DR SMR; A6U1B4; -.
DR KEGG; sah:SaurJH1_1381; -.
DR HOGENOM; CLU_002472_4_0_9; -.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT CHAIN 1..872
FT /note="DNA mismatch repair protein MutS"
FT /id="PRO_1000075564"
FT BINDING 602..609
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ SEQUENCE 872 AA; 99904 MW; F738490A82EFD590 CRC64;
MSNVTPMMQQ YLKIKSEYQD CLLFFRLGDF YEMFYEDAKE ASRVLEITLT KRDAKKENPI
PMCGVPYHSA DSYIDTLVNN GYKVAICEQM EDPKQTKGMV RREVVRIVTP GTVMEQGGVD
DKQNNYILSF VMNQPEIALS YCDVSTGELK VTHFNDEATL LNEITTINPN EVVINDNISD
NLKRQINMVT ETITVRETLS SEIYSVNQTE HKLMYQATQL LLDYIHHTQK RDLSHIEDVV
QYAAIDYMKM DFYAKRNLEL TESIRLKSKK GTLLWLMDET KTPMGARRLK QWIDRPLISK
EQIEARLDIV DEFSAHFIER DTLRTYLNQV YDIERLVGRV SYGNVNARDL IQLKHSISEI
PNIKALLNSM NQNTLVQVNQ LEPLDDLLDI LEQSLVEEPP ISVKDGGLFK VGFNTQLDEY
LEASKNGKTW LAELQAKERQ RTGIKSLKIS FNKVFGYFIE ITRANLQNFE PSEFGYMRKQ
TLSNAERFIT DELKEKEDII LGAEDKAIEL EYQLFVQLRE EVKKYTERLQ QQAKIISELD
CLQSFAEIAQ KYNYTRPSFS ENKTLELVES RHPVVERVMD YNDYVPNNCR LDNETFIYLI
TGPNMSGKST YMRQVAIISI MAQMGAYVPC KEAVLPIFDQ IFTRIGAADD LVSGKSTFMV
EMLEAQKALT YATEDSLIIF DEIGRGTSTY DGLALAQAMI EYVAETSHAK TLFSTHYHEL
TTLDQALPSL KNVHVAANEY KGELIFLHKV KDGAVDDSYG IQVAKLADLP EKVISRAQVI
LSEFEASAGK KSSISNLKMV ENEPEINQEN LNLSVEETTD TLSQKDFEQA SFDLFENDQE
SEIELQIKNL NLSNMTPIEA LVKLSELQNQ LK
//
