ID A6UU28_META3 Unreviewed; 906 AA.
AC A6UU28;
DT 21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT 21-AUG-2007, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE SubName: Full=UDP-glucose 6-dehydrogenase {ECO:0000313|EMBL:ABR56000.1};
DE EC=1.1.1.22 {ECO:0000313|EMBL:ABR56000.1};
GN OrderedLocusNames=Maeo_0414 {ECO:0000313|EMBL:ABR56000.1};
OS Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 /
OS Nankai-3).
OC Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC Methanococcaceae; Methanococcus.
OX NCBI_TaxID=419665 {ECO:0000313|EMBL:ABR56000.1, ECO:0000313|Proteomes:UP000001106};
RN [1] {ECO:0000313|EMBL:ABR56000.1, ECO:0000313|Proteomes:UP000001106}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3
RC {ECO:0000313|Proteomes:UP000001106};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A.,
RA Sieprawska-Lupa M., Whitman W.B., Richardson P.;
RT "Complete sequence of Methanococcus aeolicus Nankai-3.";
RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the UDP-glucose/GDP-mannose dehydrogenase
CC family. {ECO:0000256|ARBA:ARBA00006601}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP000743; ABR56000.1; -; Genomic_DNA.
DR RefSeq; WP_011973132.1; NC_009635.1.
DR AlphaFoldDB; A6UU28; -.
DR STRING; 419665.Maeo_0414; -.
DR GeneID; 5326369; -.
DR KEGG; mae:Maeo_0414; -.
DR eggNOG; arCOG00253; Archaea.
DR eggNOG; arCOG03147; Archaea.
DR HOGENOM; CLU_320207_0_0_2; -.
DR OrthoDB; 59839at2157; -.
DR Proteomes; UP000001106; Chromosome.
DR GO; GO:0004519; F:endonuclease activity; IEA:InterPro.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0003979; F:UDP-glucose 6-dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0016539; P:intein-mediated protein splicing; IEA:InterPro.
DR CDD; cd00081; Hint; 1.
DR Gene3D; 2.170.16.10; Hedgehog/Intein (Hint) domain; 1.
DR Gene3D; 3.10.28.10; Homing endonucleases; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR003586; Hint_dom_C.
DR InterPro; IPR003587; Hint_dom_N.
DR InterPro; IPR036844; Hint_dom_sf.
DR InterPro; IPR027434; Homing_endonucl.
DR InterPro; IPR006142; INTEIN.
DR InterPro; IPR030934; Intein_C.
DR InterPro; IPR004042; Intein_endonuc.
DR InterPro; IPR006141; Intein_N.
DR InterPro; IPR004860; LAGLIDADG_2.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR017476; UDP-Glc/GDP-Man.
DR InterPro; IPR014027; UDP-Glc/GDP-Man_DH_C.
DR InterPro; IPR036220; UDP-Glc/GDP-Man_DH_C_sf.
DR InterPro; IPR014026; UDP-Glc/GDP-Man_DH_dimer.
DR InterPro; IPR001732; UDP-Glc/GDP-Man_DH_N.
DR NCBIfam; TIGR01445; intein_Nterm; 1.
DR NCBIfam; TIGR03026; NDP-sugDHase; 1.
DR PANTHER; PTHR43750; UDP-GLUCOSE 6-DEHYDROGENASE TUAD; 1.
DR PANTHER; PTHR43750:SF3; UDP-GLUCOSE 6-DEHYDROGENASE TUAD; 1.
DR Pfam; PF14890; Intein_splicing; 1.
DR Pfam; PF14528; LAGLIDADG_3; 2.
DR Pfam; PF00984; UDPG_MGDP_dh; 1.
DR Pfam; PF03720; UDPG_MGDP_dh_C; 1.
DR Pfam; PF03721; UDPG_MGDP_dh_N; 1.
DR PRINTS; PR00379; INTEIN.
DR SMART; SM00305; HintC; 1.
DR SMART; SM00306; HintN; 1.
DR SMART; SM00984; UDPG_MGDP_dh_C; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51294; Hedgehog/intein (Hint) domain; 1.
DR SUPFAM; SSF55608; Homing endonucleases; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF52413; UDP-glucose/GDP-mannose dehydrogenase C-terminal domain; 1.
DR PROSITE; PS50818; INTEIN_C_TER; 1.
DR PROSITE; PS50819; INTEIN_ENDONUCLEASE; 1.
DR PROSITE; PS50817; INTEIN_N_TER; 1.
PE 3: Inferred from homology;
KW Autocatalytic cleavage {ECO:0000256|ARBA:ARBA00022813};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:ABR56000.1};
KW Protein splicing {ECO:0000256|ARBA:ARBA00023000}.
FT DOMAIN 477..623
FT /note="DOD-type homing endonuclease"
FT /evidence="ECO:0000259|PROSITE:PS50819"
FT DOMAIN 702..724
FT /note="Intein C-terminal splicing"
FT /evidence="ECO:0000259|PROSITE:PS50818"
SQ SEQUENCE 906 AA; 103347 MW; 4E093D7B882BAF10 CRC64;
MKISVIGTGY VGLIQSVGLA EFGFDVVGID IDETKVKRLN EGKCPLYEDG LEELLTNNIN
KNLKFTTSYQ EIKDSDIIFL CVGTPQDEKG NADLRFIYSA TESIKKQLTK DSYKVIVLKS
TVPIGTNRKI KESLKDYIVD VVSNPEFLRE GIAVDDFFNP ERIVLGFENL ENKKPIEAMK
KIYGEFEDKG APIIITDWES AEMIKYASNA FLATKISFAN ELSKLSDEVG ADIKTISEAM
GIDKRIGNKF LNAGIGYGGS CFHPDEILFV DFGDGLECMA FKELFDELSR DNNRSVKILS
INKNLKLDLA NLKLITKRDY SDDLIVLKTT MGREIKITKD HPVVVLNGDK LHVKLAENIK
EGDEIALPKG EFNSNSNINN IITIDILEEI KNTPLIEKTY LNNKNMVLNE FENIRAHLSN
KYIHDIKKNG TVRAKDMLPI RSILNKYNYN SNRLFTVRSK STTIPSVIKI DGDFARLIGY
YLAEGWISED GKKNGAIRKR ISFSFGAHEE EYINDVKNIL NKLDINYIEK IRNGSHSIII
SSKLLAYIFE EALKCGNNCY NKQIPPQIFN SPSDIKWEFL KGILRGDGGI VKLNNNKNLN
IEYGTVSKKL ANSLMILLQS LGIITSLKRC YNNKSTTLTY IIRINGLNQV KKIGELFGDK
WNNYKEIADN YERNIKPIGY KKFDNYASLK VKSVEREYYG GEVYSVETDN NLLISSYGLL
IHNCFPKDVR ALINQFENHN ISPKLIKATD EVNDEQIKWF FDKIKNYYNN DINQKTFAVL
GLAFKPNTDD LRESRGIKLI DLLLEDGAIV KGFDYVEKAR ENTINKYKLD KSKAFYGYNL
YVLDDLYETV KDVDAIIITT EYDFNDEDWE KINKLVKDKV VFDGRNILDM DKIKKLGFEY
YGVGRK
//
