ID A6UUR5_META3 Unreviewed; 811 AA.
AC A6UUR5;
DT 21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT 21-AUG-2007, sequence version 1.
DT 27-MAR-2024, entry version 99.
DE RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN OrderedLocusNames=Maeo_0653 {ECO:0000313|EMBL:ABR56237.1};
OS Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 /
OS Nankai-3).
OC Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC Methanococcaceae; Methanococcus.
OX NCBI_TaxID=419665 {ECO:0000313|EMBL:ABR56237.1, ECO:0000313|Proteomes:UP000001106};
RN [1] {ECO:0000313|EMBL:ABR56237.1, ECO:0000313|Proteomes:UP000001106}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3
RC {ECO:0000313|Proteomes:UP000001106};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A.,
RA Sieprawska-Lupa M., Whitman W.B., Richardson P.;
RT "Complete sequence of Methanococcus aeolicus Nankai-3.";
RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632,
CC ECO:0000256|RuleBase:RU000442};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC {ECO:0000256|ARBA:ARBA00005755, ECO:0000256|RuleBase:RU000442}.
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DR EMBL; CP000743; ABR56237.1; -; Genomic_DNA.
DR RefSeq; WP_011973369.1; NC_009635.1.
DR AlphaFoldDB; A6UUR5; -.
DR STRING; 419665.Maeo_0653; -.
DR GeneID; 5327261; -.
DR KEGG; mae:Maeo_0653; -.
DR eggNOG; arCOG00328; Archaea.
DR HOGENOM; CLU_000203_6_0_2; -.
DR OrthoDB; 323192at2157; -.
DR Proteomes; UP000001106; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd05780; DNA_polB_Kod1_like_exo; 1.
DR CDD; cd05536; POLBc_B3; 1.
DR Gene3D; 1.10.132.60; DNA polymerase family B, C-terminal domain; 1.
DR Gene3D; 3.30.342.10; DNA Polymerase, chain B, domain 1; 1.
DR Gene3D; 1.10.287.690; Helix hairpin bin; 1.
DR Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR042087; DNA_pol_B_thumb.
DR InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR NCBIfam; TIGR00592; pol2; 1.
DR PANTHER; PTHR10322; DNA POLYMERASE CATALYTIC SUBUNIT; 1.
DR PANTHER; PTHR10322:SF23; DNA POLYMERASE DELTA CATALYTIC SUBUNIT; 1.
DR Pfam; PF00136; DNA_pol_B; 1.
DR Pfam; PF03104; DNA_pol_B_exo1; 1.
DR PRINTS; PR00106; DNAPOLB.
DR SMART; SM00486; POLBc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|RuleBase:RU000442};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU000442};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932,
KW ECO:0000256|RuleBase:RU000442};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|RuleBase:RU000442};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU000442}.
FT DOMAIN 145..298
FT /note="DNA-directed DNA polymerase family B exonuclease"
FT /evidence="ECO:0000259|Pfam:PF03104"
FT DOMAIN 367..791
FT /note="DNA-directed DNA polymerase family B
FT multifunctional"
FT /evidence="ECO:0000259|Pfam:PF00136"
SQ SEQUENCE 811 AA; 94742 MW; 06985D571E217C70 CRC64;
MLLDIDYNSK ENRIYIYTTK KIIKKDFKPY LYIDADKNTI NKFIDEEEPQ LKEYITAIER
VKKIIINLND IENPYKNRTV EKTLSKITTD HPKDIPKLRK LQKIKANQRL ANFPNGKIGT
TYEHDIPFTK RYLIDNNKNI DLLNYNNIPD LKAVSFDMEV HFKDREPEPE KDAILMTSFY
SHDKKINKKI KKVITYKPFE HESVEIVKDE KELIKKTMEL LKQYNIIYTY NGDNFDFPYL
KRRAEHLKIP LNFGENHKLK LSKGGMNLKS AISGIVHIDL YPIARRTLNL TKYKLEDVSK
ELFNIEKLEV GHHNIVPLWN NNNPKLVEYS LQDAEYTYKI GEYFLPLEIM FSNIVGQCLF
DISRMSSSNM VEYLLLKHSF NKNYLAPNRP YGNEYQNRLK EGYEGGYVKE PIKGMHDNIV
SMDFRALYPS IIISYNISPD TINCPCCGDT NDKILGYWFC KKKIGIIPEI LKDLIERRKN
IKDVLKNKNT TENNKDDNNK NNNENYKLLN YEQQSIKILA NSFYGYMAYP RARWYSKECA
EVITHLGRAY IRKTIEEAEN NGFNVIYADT DGLYAILDEN KNKNTNKENI LNKTIKFLNE
INRELPEKME LEFEGYYKRG IFITKKRYAL IDENNKIIVK GLEFVRRDWS NIAKKTQKKV
LNTLLKEGDV ETAKQIIKDT INDLKNLPQS KIGESPGGDK KINPKDLIIY KQLTKDISEY
STATPHIAVA KKMRDRGDRL KIGDVIGFVI VNGSSPISER ATIPEQATNY DANYYIDNQV
LPPVLRIMEA IGITKDELKN NNKQITLDNF F
//
