ID A6UVV5_META3 Unreviewed; 222 AA.
AC A6UVV5;
DT 21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT 21-AUG-2007, sequence version 1.
DT 27-MAR-2024, entry version 85.
DE RecName: Full=Putative thymidylate synthase {ECO:0000256|HAMAP-Rule:MF_01686};
DE Short=TS {ECO:0000256|HAMAP-Rule:MF_01686};
DE Short=TSase {ECO:0000256|HAMAP-Rule:MF_01686};
DE EC=2.1.1.- {ECO:0000256|HAMAP-Rule:MF_01686};
GN Name=thyA {ECO:0000256|HAMAP-Rule:MF_01686};
GN OrderedLocusNames=Maeo_1049 {ECO:0000313|EMBL:ABR56627.1};
OS Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 /
OS Nankai-3).
OC Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC Methanococcaceae; Methanococcus.
OX NCBI_TaxID=419665 {ECO:0000313|EMBL:ABR56627.1, ECO:0000313|Proteomes:UP000001106};
RN [1] {ECO:0000313|EMBL:ABR56627.1, ECO:0000313|Proteomes:UP000001106}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3
RC {ECO:0000313|Proteomes:UP000001106};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A.,
RA Sieprawska-Lupa M., Whitman W.B., Richardson P.;
RT "Complete sequence of Methanococcus aeolicus Nankai-3.";
RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May catalyze the biosynthesis of dTMP using an unknown
CC cosubstrate. {ECO:0000256|HAMAP-Rule:MF_01686}.
CC -!- PATHWAY: Pyrimidine metabolism; dTTP biosynthesis. {ECO:0000256|HAMAP-
CC Rule:MF_01686}.
CC -!- SUBUNIT: Monomer. {ECO:0000256|HAMAP-Rule:MF_01686}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01686}.
CC -!- SIMILARITY: Belongs to the thymidylate synthase family. Archaeal-type
CC ThyA subfamily. {ECO:0000256|HAMAP-Rule:MF_01686}.
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DR EMBL; CP000743; ABR56627.1; -; Genomic_DNA.
DR RefSeq; WP_011973759.1; NC_009635.1.
DR AlphaFoldDB; A6UVV5; -.
DR STRING; 419665.Maeo_1049; -.
DR GeneID; 75306152; -.
DR KEGG; mae:Maeo_1049; -.
DR eggNOG; arCOG03214; Archaea.
DR HOGENOM; CLU_084975_0_0_2; -.
DR OrthoDB; 50118at2157; -.
DR UniPathway; UPA00575; -.
DR Proteomes; UP000001106; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004799; F:thymidylate synthase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006231; P:dTMP biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0006235; P:dTTP biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd00351; TS_Pyrimidine_HMase; 1.
DR Gene3D; 3.30.572.10; Thymidylate synthase/dCMP hydroxymethylase domain; 1.
DR HAMAP; MF_01686; Thymidy_synth_arch; 1.
DR InterPro; IPR045097; Thymidate_synth/dCMP_Mease.
DR InterPro; IPR023451; Thymidate_synth/dCMP_Mease_dom.
DR InterPro; IPR036926; Thymidate_synth/dCMP_Mease_sf.
DR InterPro; IPR014620; Thymidylate_synthase_arc.
DR InterPro; IPR020940; Thymidylate_synthase_AS.
DR NCBIfam; TIGR03283; thy_syn_methano; 1.
DR PANTHER; PTHR11548; THYMIDYLATE SYNTHASE 1; 1.
DR PANTHER; PTHR11548:SF1; THYMIDYLATE SYNTHASE-RELATED; 1.
DR Pfam; PF00303; Thymidylat_synt; 1.
DR PIRSF; PIRSF036752; TSase_MJ051; 1.
DR SUPFAM; SSF55831; Thymidylate synthase/dCMP hydroxymethylase; 1.
DR PROSITE; PS00091; THYMIDYLATE_SYNTHASE; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01686};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|HAMAP-
KW Rule:MF_01686};
KW Nucleotide biosynthesis {ECO:0000256|ARBA:ARBA00022727, ECO:0000256|HAMAP-
KW Rule:MF_01686};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|HAMAP-
KW Rule:MF_01686}.
FT DOMAIN 81..204
FT /note="Thymidylate synthase/dCMP hydroxymethylase"
FT /evidence="ECO:0000259|Pfam:PF00303"
FT ACT_SITE 139
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01686,
FT ECO:0000256|PROSITE-ProRule:PRU10016"
SQ SEQUENCE 222 AA; 25838 MW; 528AC1B087BE4AEA CRC64;
MYCIKKPSVR ASYEELVKEV LKNGEDMITE DGQKCREIRN TVIEITNPKL KSISPKYPLG
KKAVEQYTNN LLYGSENVFS YDYHSRLFKY PVNNKEINQI DFIVEKLKEQ QNSRRCVAIT
WQPNIDIEVS NKDHGSVPCL QFVQFLIRDN KLYQTVLFRS NDLAVAFVSN ALGLIALGEM
VAEKVGVDYG TYTHHSVSMH IYIDRDRDYI EKYFPESLKY LE
//
