ID A6VQ34_ACTSZ Unreviewed; 772 AA.
AC A6VQ34;
DT 21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT 21-AUG-2007, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=DNA internalization-related competence protein ComEC/Rec2 {ECO:0000313|EMBL:ABR75081.1};
GN OrderedLocusNames=Asuc_1729 {ECO:0000313|EMBL:ABR75081.1};
OS Actinobacillus succinogenes (strain ATCC 55618 / DSM 22257 / CCUG 43843 /
OS 130Z).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Actinobacillus.
OX NCBI_TaxID=339671 {ECO:0000313|EMBL:ABR75081.1, ECO:0000313|Proteomes:UP000001114};
RN [1] {ECO:0000313|Proteomes:UP000001114}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 55618 / DSM 22257 / CCUG 43843 / 130Z
RC {ECO:0000313|Proteomes:UP000001114};
RX PubMed=21118570; DOI=10.1186/1471-2164-11-680;
RA McKinlay J.B., Laivenieks M., Schindler B.D., McKinlay A.A.,
RA Siddaramappa S., Challacombe J.F., Lowry S.R., Clum A., Lapidus A.L.,
RA Burkhart K.B., Harkins V., Vieille C.;
RT "A genomic perspective on the potential of Actinobacillus succinogenes for
RT industrial succinate production.";
RL BMC Genomics 11:680-680(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP000746; ABR75081.1; -; Genomic_DNA.
DR AlphaFoldDB; A6VQ34; -.
DR STRING; 339671.Asuc_1729; -.
DR KEGG; asu:Asuc_1729; -.
DR eggNOG; COG0658; Bacteria.
DR eggNOG; COG2333; Bacteria.
DR HOGENOM; CLU_010363_3_0_6; -.
DR Proteomes; UP000001114; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0030420; P:establishment of competence for transformation; IEA:InterPro.
DR CDD; cd07731; ComA-like_MBL-fold; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR035681; ComA-like_MBL.
DR InterPro; IPR004477; ComEC_N.
DR InterPro; IPR004797; Competence_ComEC/Rec2.
DR InterPro; IPR025405; DUF4131.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR NCBIfam; TIGR00360; ComEC_N-term; 1.
DR NCBIfam; TIGR00361; ComEC_Rec2; 1.
DR PANTHER; PTHR30619; DNA INTERNALIZATION/COMPETENCE PROTEIN COMEC/REC2; 1.
DR PANTHER; PTHR30619:SF1; RECOMBINATION PROTEIN 2; 1.
DR Pfam; PF03772; Competence; 1.
DR Pfam; PF13567; DUF4131; 1.
DR Pfam; PF00753; Lactamase_B; 1.
DR SMART; SM00849; Lactamase_B; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001114};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..28
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 212..238
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 310..329
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 350..372
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 378..404
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 441..460
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 528..710
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|SMART:SM00849"
SQ SEQUENCE 772 AA; 86325 MW; AAEDB1E7CDB31FEA CRC64;
MFLPGSRLLS LDSLFGVLFI FIVLNAYFYS RRKPRAFSIA LLGLGGCVGV AISHTQALHL
FEQAQAVSVR NITAEFRIQK VQHSGDYQTA IVRNTANRQL NYVTWNNPLP VKAGEIWRLE
MRQRPLSSRL NQGGSDRQAW YFSQGITATG TVKSAVKIRD DFSWRETRFH QAFERTAALS
QQGLLLALGF GERAWLSPEI RKVYQRTNTA HLIAISGLHI GLAMMLGTVL GRVLQFFLPT
IRISPLFPLF TGVSLAWIYV NLAGFAVSTS RALLALLLVT GLRMTRGYCS AWQLFIYGVA
LLLLSNPLMV LSVGFWLSAG AVFCLILWYR IFPLRAVRWR NRPIPVKVRW IFALLHLQFG
LLWLFTPVQV ALFNGFSWAG LAANLIAVPF FSFLLVPLVL FAVLTDGAGA TWQIADQLAQ
WIARLIMRFD GYWLTVSEKT GWILTALLTL CLLMFIRRLY RELAQPAPSL PSHTPSLGGF
SLFSENKPAE LSGIVIGCLL LLSLCGGRLA YLWLQEPDWR VETLDVGQGL ATLIVKNQRA
VLYDTGVAWE GGSMAEIEIL PYLQRQGIVP EQLILSHDDK DHAGGARVIL RTYPDIELIT
PSHKNYGKTD RTFCVKGLNW HWQGLTFEAL SPAEIVPRAE NGDSCIIRVS DGIHRVLLTG
DADVAAENRI IDRLGKINVL QVGHHGSKTS TGSRLVRQIR PDIALISSGR WNPWHFPHPS
VTERLIRVQS AVKNTAVSGQ ISVRFHGGKM ALETVRTDFS PWYRGFIGES TK
//
