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Database: UniProt
Entry: A6W2U0_MARMS
LinkDB: A6W2U0_MARMS
Original site: A6W2U0_MARMS 
ID   A6W2U0_MARMS            Unreviewed;       422 AA.
AC   A6W2U0;
DT   21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT   21-AUG-2007, sequence version 1.
DT   28-FEB-2018, entry version 72.
DE   SubName: Full=Malate dehydrogenase (Oxaloacetate-decarboxylating) (NADP(+)) {ECO:0000313|EMBL:ABR73019.1};
DE            EC=1.1.1.40 {ECO:0000313|EMBL:ABR73019.1};
GN   OrderedLocusNames=Mmwyl1_4123 {ECO:0000313|EMBL:ABR73019.1};
OS   Marinomonas sp. (strain MWYL1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Oceanospirillales;
OC   Oceanospirillaceae; Marinomonas.
OX   NCBI_TaxID=400668 {ECO:0000313|EMBL:ABR73019.1, ECO:0000313|Proteomes:UP000001113};
RN   [1] {ECO:0000313|EMBL:ABR73019.1, ECO:0000313|Proteomes:UP000001113}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MWYL1 {ECO:0000313|EMBL:ABR73019.1,
RC   ECO:0000313|Proteomes:UP000001113};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T.,
RA   Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D.,
RA   Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L.,
RA   Kyrpides N., Kim E., Johnston A.W.B., Todd J.D., Rogers R., Wexler M.,
RA   Bond P.L., Li Y., Richardson P.;
RT   "Complete sequence of Marinomonas sp. MWYL1.";
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR000106-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR000106-3};
CC       Note=Divalent metal cations. Prefers magnesium or manganese.
CC       {ECO:0000256|PIRSR:PIRSR000106-3};
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DR   EMBL; CP000749; ABR73019.1; -; Genomic_DNA.
DR   RefSeq; WP_012071784.1; NC_009654.1.
DR   ProteinModelPortal; A6W2U0; -.
DR   STRING; 400668.Mmwyl1_4123; -.
DR   EnsemblBacteria; ABR73019; ABR73019; Mmwyl1_4123.
DR   KEGG; mmw:Mmwyl1_4123; -.
DR   eggNOG; ENOG4105C6K; Bacteria.
DR   eggNOG; COG0281; LUCA.
DR   HOGENOM; HOG000132447; -.
DR   KO; K00029; -.
DR   OMA; ILFKQFG; -.
DR   OrthoDB; POG091H02AU; -.
DR   BioCyc; MSP400668:G1G9E-4272-MONOMER; -.
DR   Proteomes; UP000001113; Chromosome.
DR   GO; GO:0004471; F:malate dehydrogenase (decarboxylating) (NAD+) activity; IEA:InterPro.
DR   GO; GO:0004473; F:malate dehydrogenase (decarboxylating) (NADP+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0008948; F:oxaloacetate decarboxylase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.50.10380; -; 1.
DR   InterPro; IPR015884; Malic_enzyme_CS.
DR   InterPro; IPR012301; Malic_N_dom.
DR   InterPro; IPR037062; Malic_N_dom_sf.
DR   InterPro; IPR012302; Malic_NAD-bd.
DR   InterPro; IPR001891; Malic_OxRdtase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00390; malic; 1.
DR   Pfam; PF03949; Malic_M; 1.
DR   PIRSF; PIRSF000106; ME; 1.
DR   SMART; SM01274; malic; 1.
DR   SMART; SM00919; Malic_M; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00331; MALIC_ENZYMES; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001113};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR000106-3};
KW   Oxidoreductase {ECO:0000313|EMBL:ABR73019.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001113}.
FT   DOMAIN       18    151       malic. {ECO:0000259|SMART:SM01274}.
FT   DOMAIN      163    399       Malic_M. {ECO:0000259|SMART:SM00919}.
FT   ACT_SITE     39     39       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR000106-1}.
FT   ACT_SITE     94     94       Proton acceptor. {ECO:0000256|PIRSR:
FT                                PIRSR000106-1}.
FT   METAL       136    136       Divalent metal cation.
FT                                {ECO:0000256|PIRSR:PIRSR000106-3}.
FT   METAL       137    137       Divalent metal cation.
FT                                {ECO:0000256|PIRSR:PIRSR000106-3}.
FT   METAL       162    162       Divalent metal cation.
FT                                {ECO:0000256|PIRSR:PIRSR000106-3}.
SQ   SEQUENCE   422 AA;  45003 MW;  9F26483C21B7F054 CRC64;
     MAEDIKQAAL DYHEYPVPGK LSVTITKPTA TARDLSLAYS PGVAEPCREI AKDPEAAYRY
     TGKGNLVAVI SDGTAILGLG NLGPLASKPV MEGKGLLFKR FAGINSVDVE VESESPQAFI
     DTVARIANTY GGINLEDIKA PECFEIERQL IERCSIPVFH DDQHGTAIVT AAGLLNALEL
     QGKDIADAKI VCLGAGAAAT ACMKLIIACG AQRENIFVLD RNGVIHSGRT DLNQFKAMFA
     IDTDKRTLDD AIEGADVFIG VSGPDLLSAD QLAKMAANPI VFACSNPDPE INPELARATR
     DDLIMATGRS DYPNQVNNVL GFPFIFRGAL DVRATKINEE MKLAAVHALK DLAKEEAPAD
     VVAAYGGTPL SFGKEYILPK PMDTRLLNVV SAAVARAAVD SGVAMLPYPD FYPLENLDHF
     GA
//
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