ID A7AM03_BABBO Unreviewed; 864 AA.
AC A7AM03;
DT 11-SEP-2007, integrated into UniProtKB/TrEMBL.
DT 11-SEP-2007, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=KOW motif family protein {ECO:0000313|EMBL:EDO07587.1};
GN ORFNames=BBOV_III000200 {ECO:0000313|EMBL:EDO07587.1};
OS Babesia bovis.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Piroplasmida;
OC Babesiidae; Babesia.
OX NCBI_TaxID=5865 {ECO:0000313|EMBL:EDO07587.1, ECO:0000313|Proteomes:UP000002173};
RN [1] {ECO:0000313|EMBL:EDO07587.1, ECO:0000313|Proteomes:UP000002173}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T2Bo {ECO:0000313|EMBL:EDO07587.1};
RX PubMed=17953480; DOI=10.1371/journal.ppat.0030148;
RA Brayton K.A., Lau A.O.T., Herndon D.R., Hannick L., Kappmeyer L.S.,
RA Berens S.J., Bidwell S.L., Brown W.C., Crabtree J., Fadrosh D.,
RA Feldblum T., Forberger H.A., Haas B.J., Howell J.M., Khouri H., Koo H.,
RA Mann D.J., Norimine J., Paulsen I.T., Radune D., Ren Q., Smith R.K. Jr.,
RA Suarez C.E., White O., Wortman J.R., Knowles D.P. Jr., McElwain T.F.,
RA Nene V.M.;
RT "Genome sequence of Babesia bovis and comparative analysis of apicomplexan
RT hemoprotozoa.";
RL PLoS Pathog. 3:1401-1413(2007).
RN [2] {ECO:0000313|Proteomes:UP000002173}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=33294524; DOI=10.1016/j.dib.2020.106533;
RA Ueti M.W., Johnson W.C., Kappmeyer L.S., Herndon D.R., Mousel M.R.,
RA Reif K.E., Taus N.S., Ifeonu O.O., Silva J.C., Suarez C.E., Brayton K.A.;
RT "Transcriptome dataset of Babesia bovis life stages within vertebrate and
RT invertebrate hosts.";
RL Data Brief 33:106533-106533(2020).
RN [3] {ECO:0000313|Proteomes:UP000002173}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=33069745;
RA Ueti M.W., Johnson W.C., Kappmeyer L.S., Herndon D.R., Mousel M.R.,
RA Reif K.E., Taus N.S., Ifeonu O.O., Silva J.C., Suarez C.E., Brayton K.A.;
RT "Comparative analysis of gene expression between Babesia bovis blood stages
RT and kinetes allowed by improved genome annotation.";
RL Int. J. Parasitol. 51:123-136(2021).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the SPT5 family.
CC {ECO:0000256|ARBA:ARBA00006956}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDO07587.1}.
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DR EMBL; AAXT01000001; EDO07587.1; -; Genomic_DNA.
DR RefSeq; XP_001611155.1; XM_001611105.1.
DR AlphaFoldDB; A7AM03; -.
DR STRING; 5865.A7AM03; -.
DR EnsemblProtists; EDO07587; EDO07587; BBOV_III000200.
DR GeneID; 5479400; -.
DR KEGG; bbo:BBOV_III000200; -.
DR VEuPathDB; PiroplasmaDB:BBOV_III000200; -.
DR eggNOG; KOG1999; Eukaryota.
DR InParanoid; A7AM03; -.
DR OMA; FLAWDVE; -.
DR Proteomes; UP000002173; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:1990904; C:ribonucleoprotein complex; IEA:UniProtKB-KW.
DR GO; GO:0005840; C:ribosome; IEA:UniProtKB-KW.
DR GO; GO:0006354; P:DNA-templated transcription elongation; IEA:InterPro.
DR GO; GO:0032784; P:regulation of DNA-templated transcription elongation; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd06081; KOW_Spt5_1; 1.
DR CDD; cd06084; KOW_Spt5_4; 1.
DR CDD; cd09888; NGN_Euk; 1.
DR Gene3D; 2.30.30.30; -; 3.
DR Gene3D; 3.30.70.940; NusG, N-terminal domain; 1.
DR InterPro; IPR005824; KOW.
DR InterPro; IPR041973; KOW_Spt5_1.
DR InterPro; IPR041977; KOW_Spt5_4.
DR InterPro; IPR005100; NGN-domain.
DR InterPro; IPR036735; NGN_dom_sf.
DR InterPro; IPR039385; NGN_Euk.
DR InterPro; IPR014722; Rib_uL2_dom2.
DR InterPro; IPR039659; SPT5.
DR InterPro; IPR017071; TF_Spt5_eukaryote.
DR InterPro; IPR008991; Translation_prot_SH3-like_sf.
DR PANTHER; PTHR11125; SUPPRESSOR OF TY 5; 1.
DR PANTHER; PTHR11125:SF7; TRANSCRIPTION ELONGATION FACTOR SPT5; 1.
DR Pfam; PF03439; Spt5-NGN; 1.
DR PIRSF; PIRSF036945; Spt5; 2.
DR SMART; SM00739; KOW; 6.
DR SUPFAM; SSF50104; Translation proteins SH3-like domain; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002173}.
FT DOMAIN 251..278
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 409..436
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 460..487
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 586..613
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 666..693
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 754..782
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 864 AA; 97443 MW; 0EE8107E050E5174 CRC64;
MARHKVDVDD LSFPESDASS DNDKPTRKKL KLQSAEAKRR AIVSAFLDTE AQVGDEEDEE
NYEEDLFLPD ESTEAENLEN RSRIRRMLDE PERKEDRRIG GAGLLENAID KLTKRYQDMT
FDEEDEDFID DGEAEAEQSY GVIEDANVLI PDINDPKLWM LKLNKSQSSK FVAISLLNKF
LKLQGQGRKL GIYSCFAPDE IKSFIYVEAD TKSAIIDAFS DLRNLNLSKL KMVPINEVST
IYAMESRQQT VPLIGEYVRI KTGRYAGDLA QVHESDELNG TVVVKVIPRL QEDSKNFEGL
NVDDKGSEFN FNKANMVKKT KSKIFVKRLF DREAVELKGG LIEQGFTPGT FRYNNMTFLD
AGFLLLRISV RRIVVGSAVD ATLSELKEFN LEDNYGNVAN VINTSNLHLF RLGEKIRVTR
GELINVIGHI ASMHNDEIEI QPEDESIPNF KIQPSCVMKY FQEGDNVRII DGINRGESGL
ISIVDFEKKT AVVFSPQKSE QFKVKLDYLV KVKETVSFES LGSLNGYFLG DLIQSSKGEV
GIIVSISKSC FTVLLDTNVE AKWVMSDILC KRSSFGYSSK DVNNATLYTH NKVLIVNGPY
KNKQGVVKHL WKNKCFVQLE KNVYLVVDSG VVLNMSISET PNFAEQREAP ERGLESRYKN
KIRVPNKFIG KTVKILVGRH KGLLGDVISV DQSEFTIILK VKPMVVRIKK VDVTILDNRD
LMVSKMRYAN TLFDKSSLKS KQLSNQTGKQ VNKWIKRGVV IRIIGNGEYR NKIGIIDEVV
EDQADTDLQI VHVFVDEDYI AIAAESVEVL RPTKENQVVT LLRENDVIGT VVSVGETHVT
VRLENGSDIE EAVENLALYG SLNI
//
