ID A7AP42_BABBO Unreviewed; 3963 AA.
AC A7AP42;
DT 11-SEP-2007, integrated into UniProtKB/TrEMBL.
DT 11-SEP-2007, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=FAT domain-containing protein {ECO:0000259|PROSITE:PS51189};
GN ORFNames=BBOV_III007660 {ECO:0000313|EMBL:EDO08326.1};
OS Babesia bovis.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Piroplasmida;
OC Babesiidae; Babesia.
OX NCBI_TaxID=5865 {ECO:0000313|EMBL:EDO08326.1, ECO:0000313|Proteomes:UP000002173};
RN [1] {ECO:0000313|EMBL:EDO08326.1, ECO:0000313|Proteomes:UP000002173}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T2Bo {ECO:0000313|EMBL:EDO08326.1};
RX PubMed=17953480; DOI=10.1371/journal.ppat.0030148;
RA Brayton K.A., Lau A.O.T., Herndon D.R., Hannick L., Kappmeyer L.S.,
RA Berens S.J., Bidwell S.L., Brown W.C., Crabtree J., Fadrosh D.,
RA Feldblum T., Forberger H.A., Haas B.J., Howell J.M., Khouri H., Koo H.,
RA Mann D.J., Norimine J., Paulsen I.T., Radune D., Ren Q., Smith R.K. Jr.,
RA Suarez C.E., White O., Wortman J.R., Knowles D.P. Jr., McElwain T.F.,
RA Nene V.M.;
RT "Genome sequence of Babesia bovis and comparative analysis of apicomplexan
RT hemoprotozoa.";
RL PLoS Pathog. 3:1401-1413(2007).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDO08326.1}.
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DR EMBL; AAXT01000001; EDO08326.1; -; Genomic_DNA.
DR RefSeq; XP_001611894.1; XM_001611844.1.
DR STRING; 5865.A7AP42; -.
DR EnsemblProtists; EDO08326; EDO08326; BBOV_III007660.
DR VEuPathDB; PiroplasmaDB:BBOV_III007660; -.
DR eggNOG; KOG0889; Eukaryota.
DR InParanoid; A7AP42; -.
DR OMA; DITRMAT; -.
DR Proteomes; UP000002173; Chromosome 3.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF1; TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN; 1.
DR Pfam; PF02259; FAT; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002173}.
FT DOMAIN 2735..3329
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 416..451
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 843..890
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3870..3900
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..27
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 853..874
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3870..3899
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3963 AA; 448732 MW; 8F903098D117573C CRC64;
MAPEYEDAMD VNTKGQRRHH GEDMPMDSKD VAIKTNNVTD ESSRKAPSHN IVERCRELLE
DVKNGTTAEG VAKLCACFKE VKSFLLSQIS NDIIRQQLLI LLESSMKWRI PKDPMAVSPM
QFVYILDTED RLRRMRAVSL IVDLLFKQPE RARYFKKVLP KAEPFFAIQH IENDEFHHMA
IKVICQTLKC CADLTGVTLN DLEGFTRNVF DQIIELLQRT DAYESRASLM MCITLLAGSG
HNKHILAEIV MGDLLIRLNE SWKHETMVSI SIISVFVDGL EQIDDRDLLT VADNCLKLHH
IYSGTDDYHL RERLIALLAV LTKKLEKAFD NIHEVDQNTY HNIATVMFHK AAYEIQSYNM
PKHVWHDEEF ISFARTSLPA LITILSGCIN IITPQNNPTG SMQSASPISC QDTRRYDNKS
DGFRTPTGGT PRIKHDKTYG FSSESDYNRP SSRRNLTSLE IMELCKCICC IFDAGATAAT
VIGGADVSTR YDKLMQVDEF KSILRTIISS FTSTLRETEL KQWVKLIVPI VFVIGTRNRF
TLELLDCFFR EHAKHFTPHM LIFVLQILKN QHAALEYLKN VVTYSEGLVG LFSLNRWYSC
AKRLSGDVPE MLINNAHDMS IVIAKSYMTV PKSLLACHNE LQHLVTAVSK LCVTKRDPHV
KVAITIFKHI NKLREYAETM TVIRPSTDII LGKVTKAGET VHRDWLELMM AMAARGPFTV
EMVRKCVQPA MCILRDFKWD LVPAALDMVY IWTDFQSPEE AYELLSNVNL YRYSTVEPQF
IQCLSQYLQD PSLPGFRQNA DVVMAIFSRM GSLAMKYIRN LPVKNDIEHA IAVPVQMDAC
DVNLDDSSNP REKRISNGYA RSSSSSNNAD SKDTDVGESP GRSDPTASEI DNVFGLGIPV
IDGLNSVIRQ MSKRKVSFVE FDASAVFVLN AVSPLLNFSV SLSECALTLA SLNAEKKGEG
STKYFTQETT SEFIHVLMHA LVKVAAVGMS DFPRSETYRD VKQLMQTIQT YIVIVHKTHA
NTDMEVAVDP VILLQGIAAR LAVTRPSLAY NFGFAWDNVD PMEVTVASDF LLAVFAQAMN
MQCTGLCSAI VSMLCLGCNS HEKTEKAGAC IALGKICQQH PDFVKPNIHD IANSVAQICI
RITEYEGIMG ETLKALLEVD EPGIIQWAVS LLEHPLWYLR ATGQICLKVA KNKSEVQKHL
QRLMSNASNI HMPDVQLFLA TLGNGDAALL EHAVSNIQQY LQSIAGCDDS TESFRDQAYA
LVDMLGQLLI NEEYSKMAPD MEHIFNMVLV WFIKLVMIGG SQIAQKAKGI LDSSKNVSVT
AKTLSMALEE YIFQLQTIFD DRLLEKILAV LKQYRAVLDD ALTESLLNVA KALVENMLNS
SINDEYQNAN FLEYLVFIAN IGARRSCTDL IFKQWFIRVD CIRKGVIIPG SVAYGIWQVI
SSEGVIHNIF NTSMKTECLG LCYFIHNKAD MDHILYNVIG FLESNDVVSS LLSMSLIHWL
CVKNLDQITN LKNFKRLADL ICRLTFEDTV LIDALLAPPF SISNEKILKW KLACISAEVL
IKVTPPSSTL EKLETRNFYK DGNGIKVNRI IANAFLEIYS SDKCGSTLNP ILGGSAFNMR
NYQLRHLVPM LNKSISTMDD AVLDDLVRFF WESSIECDVL GKLLSVSCLS KIVEHKNTPP
IGAAAVLERF VDVITADETV VFLKMHHTVK LDTADPEKKG NYTLVKLLGE CADILMKALC
GVYTVPETVH SADDEPKVEL WKWIVLNKIK ALGREPGRLI PLFSLFIWHL QSCGNELDDI
LLRVLAALHS DVATQCCNMA QSGAFDAFFG AVAIVERKGI DVDLSWIKEA CIDVMAAYVD
SETFDSANVA SYIPVVAQVF SRNPSFELFS CKLNHYFTIP MDFSICRGFN HTHLRNNVSY
CIRRPDRVDA KKTFVASFKV IARAKELKAD TITRWQSAVA TVMLRIVDQT LDLVTPGSED
VQQITQLLDI MWHMDGLSLS RVMRSVLYKL CCLFKPQLIR APTSSSNDSQ STTVLSDSLE
AKALPRTAKS TECQAKVVDV RLCPLAQSYA HPFPRWLVNK VITELQGVAN DGQDATRIFD
EVQPVLAPRV PVKGSPRNPA SLTLDDWASE VKRLSASQYR IGFSNAVRSV LTLLCAVDSY
ISSSHHLRTT VLSESIQALY RMVNRIVSVD HLGTTQMITC PTLIPRVFGV ISKDERYSED
ERVNMEQLLT LATWSIAILG QDTRNQLYDV LYHITQSLDQ ISGSKLLDIA TEMMEYEDRN
TLDVDLSSKE SGVSDSTAIE SHTKVENSLQ QQLVDEARAK RSNDIVSQDI ATPVKRVNRE
DSHNACISHA VPDDIGMKAI PKVQFCKLEP CSDVSSVMID YTSWSRRDTN VCPKELTESS
DSREVGTIFE DFCSMEPKNL YTIVAYKTLL DRVKAVYASS CDKYTLDLEL VYAIRSVAHI
NSISDAYFRL MFKCLDRANN SGSHVRTRMI AYIATLPMKD RKLSDIFEEI VTPRDMYSIL
RYIFSSEISK NKDREFYIPL FLDIIFTRSL DSWGLSFSHH YPVLPALVPK NNHREVSQID
LICQDDIKHT FKNTILLLRD FRAMAKESNK VNTPMVEESI SIYVAPELLE SANVMLQKLY
RYYTEYFERI AVASRFKTCI CNMWHHDRLF ASQIWSSILP QLYSTLTKFQ QEELGSAICG
YLCLDGHLWN RGLMCKPVLQ AVIKCYPPIN IPPEVLKYIT IILGAWDEVL YHLEKQLMSQ
PLDITRMATV LSDIYESLGM NDMAIGAYRT WVITQETRLA ISFLQHAKWK QAQKEFNSIM
DSLALTGQTA EAVSSFDESK LWYNGWVHAS KQLGEWDLLR DVSFVAGDRH LFVQSSCALQ
DWGEVLPDDG LNHVSRICAL DDCESKIVRI YQQLQTDLLP FKERGSEMSS IFLINATAKA
EKMLRTGKDA IVQSWTVLPK GLSEAHHTPM RLHQRYVEVE EGMKYLTNIM QNIETGHLPQ
SSTIIRKWRQ RMPSERDIPS VWHDMLSWRT FLYSTIRTAL TNSHYLTKDD KVGAILNLQD
LQWTLTKFAS VTRKHHHNPI LASVLLNKAQ GYHKSIIDHS NVVTEDCLMI MVERIKQYLS
IPINILDMLK GVVNIDLELV PSVGCEPLKS QVVRLVAEAI SRRAGYDIAK RIPIPENELA
TNLMLESLKL EPLYAKNWQS WAKYNDKRID HAAAQMCKPG DNAFQAELYE SAIIGYLTAV
SIRPHDHWLL IGRVLTLINE MKQAGQTTCV ETIKKYSERV PASVWLLWQT QLISSLCKHG
EGEMQHILQL LMSKLPQQVF YALRSEYFVQ NSIGDVEGAP EATQPSTIRR ILSRLIASNP
NVGTMLESFA TTVAHLGRPD FVDEVLLATE TVFEECLDLP FNENIPAQMF NCLAIKMPHR
PGGSDYGISE SAFVAMMKEF ERDFVNGASG MNCGETMNLL MKWMVKLSEI SKMSHTDLLK
QRMDNMKVNQ FCKNLQMMNM ELQLPTLQPT RSLIKPKQRH CLGESRNVVS LMHYVSKRKR
GRQTVKSISL LAQNGQVYLY TVQPLSLIRQ KSEQHLTQML KLLNHYALKY NDTVKRNVTL
SSVNLVSLDP YLCLYEEDVH NEIMSQVMSQ AVSYENLVKE RPNRNGFACM HPSMYQQTNT
LLLVLHKMLM ETGVTHQLVQ RWQKFNPECT DNPGFIRVYQ LFKDKQYPWF GTWYKKIHQD
VLMEAYSEIC SLIPDDILFN YALKRFDGYQ DFMTMRRMFT SSYSIQALLG LMFLTPYATP
SKLSFNFHNG QVNQLDFKPN YSREIFVEYS KLRVFRFTRN IKTMIGPVCR MGIMPAVIYA
LCAAIHTHKV DILSALSVIL ADDQGLMQSA TSSPHYKPEQ AQANSQCSSN GSVPSTPGMP
PNRDVNILEE YLGRVLNYCS YLRSPTDQEQ YTMPINNIIT CIIDASADSG TLGKLKTSYQ
PWF
//
