ID A7APP0_BABBO Unreviewed; 1025 AA.
AC A7APP0;
DT 11-SEP-2007, integrated into UniProtKB/TrEMBL.
DT 11-SEP-2007, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Glutamate/Leucine/Phenylalanine/Valine dehydrogenase family protein {ECO:0000313|EMBL:EDO08524.1};
DE EC=1.4.1.2 {ECO:0000313|EMBL:EDO08524.1};
GN ORFNames=BBOV_III009680 {ECO:0000313|EMBL:EDO08524.1};
OS Babesia bovis.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Piroplasmida;
OC Babesiidae; Babesia.
OX NCBI_TaxID=5865 {ECO:0000313|EMBL:EDO08524.1, ECO:0000313|Proteomes:UP000002173};
RN [1] {ECO:0000313|EMBL:EDO08524.1, ECO:0000313|Proteomes:UP000002173}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T2Bo {ECO:0000313|EMBL:EDO08524.1};
RX PubMed=17953480; DOI=10.1371/journal.ppat.0030148;
RA Brayton K.A., Lau A.O.T., Herndon D.R., Hannick L., Kappmeyer L.S.,
RA Berens S.J., Bidwell S.L., Brown W.C., Crabtree J., Fadrosh D.,
RA Feldblum T., Forberger H.A., Haas B.J., Howell J.M., Khouri H., Koo H.,
RA Mann D.J., Norimine J., Paulsen I.T., Radune D., Ren Q., Smith R.K. Jr.,
RA Suarez C.E., White O., Wortman J.R., Knowles D.P. Jr., McElwain T.F.,
RA Nene V.M.;
RT "Genome sequence of Babesia bovis and comparative analysis of apicomplexan
RT hemoprotozoa.";
RL PLoS Pathog. 3:1401-1413(2007).
RN [2] {ECO:0000313|Proteomes:UP000002173}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=33294524; DOI=10.1016/j.dib.2020.106533;
RA Ueti M.W., Johnson W.C., Kappmeyer L.S., Herndon D.R., Mousel M.R.,
RA Reif K.E., Taus N.S., Ifeonu O.O., Silva J.C., Suarez C.E., Brayton K.A.;
RT "Transcriptome dataset of Babesia bovis life stages within vertebrate and
RT invertebrate hosts.";
RL Data Brief 33:106533-106533(2020).
RN [3] {ECO:0000313|Proteomes:UP000002173}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=33069745;
RA Ueti M.W., Johnson W.C., Kappmeyer L.S., Herndon D.R., Mousel M.R.,
RA Reif K.E., Taus N.S., Ifeonu O.O., Silva J.C., Suarez C.E., Brayton K.A.;
RT "Comparative analysis of gene expression between Babesia bovis blood stages
RT and kinetes allowed by improved genome annotation.";
RL Int. J. Parasitol. 51:123-136(2021).
CC -!- SIMILARITY: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
CC {ECO:0000256|ARBA:ARBA00006382}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDO08524.1}.
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DR EMBL; AAXT01000001; EDO08524.1; -; Genomic_DNA.
DR RefSeq; XP_001612092.1; XM_001612042.1.
DR AlphaFoldDB; A7APP0; -.
DR STRING; 5865.A7APP0; -.
DR EnsemblProtists; EDO08524; EDO08524; BBOV_III009680.
DR GeneID; 5480348; -.
DR KEGG; bbo:BBOV_III009680; -.
DR VEuPathDB; PiroplasmaDB:BBOV_III009680; -.
DR eggNOG; KOG2250; Eukaryota.
DR InParanoid; A7APP0; -.
DR OMA; LYCLPQN; -.
DR Proteomes; UP000002173; Unassembled WGS sequence.
DR GO; GO:0004352; F:glutamate dehydrogenase (NAD+) activity; IEA:UniProtKB-EC.
DR GO; GO:0006520; P:amino acid metabolic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR046346; Aminoacid_DH-like_N_sf.
DR InterPro; IPR006096; Glu/Leu/Phe/Val/Trp_DH_C.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR11606; GLUTAMATE DEHYDROGENASE; 1.
DR PANTHER; PTHR11606:SF42; NAD-SPECIFIC GLUTAMATE DEHYDROGENASE; 1.
DR Pfam; PF00208; ELFV_dehydrog; 1.
DR SMART; SM00839; ELFV_dehydrog; 1.
DR SUPFAM; SSF53223; Aminoacid dehydrogenase-like, N-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000313|EMBL:EDO08524.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002173}.
FT DOMAIN 657..926
FT /note="Glutamate/phenylalanine/leucine/valine/L-tryptophan
FT dehydrogenase C-terminal"
FT /evidence="ECO:0000259|SMART:SM00839"
SQ SEQUENCE 1025 AA; 116581 MW; EFD6B9FD0B87A02D CRC64;
MAIDANLDNY LHDDGLSGVV GSDETHDVPL SDRYATQFQE VYKIVKDLKT FSDDTINQTM
DQYYNKLGLN EYYFSTSNAK MIANNMVSVL TAKILHENSG SDYFPLIEQV HDGRVFIITR
ASLLNHKLSQ IYAVEKTVEQ RFLHFGDVTR PVWRMQCFRS TNSMFDDPAN LFERLRIYFF
QLPNFAENNP EPGELRLSKL LDKDFYKNKR NTITEDIFYK LNKQIVMSDG GIGLVMNGEP
REFNTFRIDV AFRQDYVQSD FYSRFGDCVT YYGCYSKSKY VDPLSNNVCI ITAFITSLPS
TELDNPDLSL LDRAHSIMTA IRLCGILPHS HYLSILTERL LNGSEMAYAY CASIFVEHFS
GSVGPHMALI ERLATREQMA PSELYDIRSK LMIPSYLPNQ IFEAVQENIP ILKQLHKNFC
ILHNPDINPN GTNTDPDSNA LKETIKTLDN QVHAKILSLF LTFNSSTLRT NFFVTEKSSF
AFRLDPSFLS KNDYPETPYG IVMLMGPFFR GFHIRFSEIS RGGIRVVQSF SHEAFTRNKL
QVFDEAYNLS YTQSLKNKDI PEGGSKGVIL LDKAPNADLA QIYTRNSFMC YVDGLLDVMM
PCAQMVDHLH QDEIYFLGPD EHTGTGRLMD WAANHAKLRG FPFWRSFTTG KEPVMGGIPH
DTYGMTTASI EAYIHELLNI FHLNEEEVTR FLTGGPDGDL GSNALLCSKT KTLTVIDKSG
VLHDPEGLDI NELQRLAANR LKGLPTSAMH YNEALLSDKG FKVPEDAVDM VLPDGTKVKR
GHKFRDEFHL GACPSDLFNP CGGRPSSITP FNVNRLFDEK GKCIYKFIVE GANVFITQDA
RRILENKGVI LFKDASTNKG GVTSSSFEVL AALVLDDDTF DEMMTVKEGG EFPQFRKDYI
NEILDIIKKN ARREFHALWN EGLRIGMPRC DLTDVLSTKI IRLKKDIIDS NSLWEDTVLV
RAVLSKAIPQ SLQKLVPIED IMVRLPDRYM RSMFASHLAS TFYYSQQFTD DTSVFAFYEY
LKALK
//
