ID A7AQS1_BABBO Unreviewed; 724 AA.
AC A7AQS1;
DT 11-SEP-2007, integrated into UniProtKB/TrEMBL.
DT 11-SEP-2007, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Bromodomain protein, putative {ECO:0000313|EMBL:EDO06890.1};
GN ORFNames=BBOV_IV005290 {ECO:0000313|EMBL:EDO06890.1};
OS Babesia bovis.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Piroplasmida;
OC Babesiidae; Babesia.
OX NCBI_TaxID=5865 {ECO:0000313|EMBL:EDO06890.1, ECO:0000313|Proteomes:UP000002173};
RN [1] {ECO:0000313|EMBL:EDO06890.1, ECO:0000313|Proteomes:UP000002173}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T2Bo {ECO:0000313|EMBL:EDO06890.1};
RX PubMed=17953480; DOI=10.1371/journal.ppat.0030148;
RA Brayton K.A., Lau A.O.T., Herndon D.R., Hannick L., Kappmeyer L.S.,
RA Berens S.J., Bidwell S.L., Brown W.C., Crabtree J., Fadrosh D.,
RA Feldblum T., Forberger H.A., Haas B.J., Howell J.M., Khouri H., Koo H.,
RA Mann D.J., Norimine J., Paulsen I.T., Radune D., Ren Q., Smith R.K. Jr.,
RA Suarez C.E., White O., Wortman J.R., Knowles D.P. Jr., McElwain T.F.,
RA Nene V.M.;
RT "Genome sequence of Babesia bovis and comparative analysis of apicomplexan
RT hemoprotozoa.";
RL PLoS Pathog. 3:1401-1413(2007).
RN [2] {ECO:0000313|Proteomes:UP000002173}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=33294524; DOI=10.1016/j.dib.2020.106533;
RA Ueti M.W., Johnson W.C., Kappmeyer L.S., Herndon D.R., Mousel M.R.,
RA Reif K.E., Taus N.S., Ifeonu O.O., Silva J.C., Suarez C.E., Brayton K.A.;
RT "Transcriptome dataset of Babesia bovis life stages within vertebrate and
RT invertebrate hosts.";
RL Data Brief 33:106533-106533(2020).
RN [3] {ECO:0000313|Proteomes:UP000002173}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=33069745;
RA Ueti M.W., Johnson W.C., Kappmeyer L.S., Herndon D.R., Mousel M.R.,
RA Reif K.E., Taus N.S., Ifeonu O.O., Silva J.C., Suarez C.E., Brayton K.A.;
RT "Comparative analysis of gene expression between Babesia bovis blood stages
RT and kinetes allowed by improved genome annotation.";
RL Int. J. Parasitol. 51:123-136(2021).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDO06890.1}.
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DR EMBL; AAXT01000002; EDO06890.1; -; Genomic_DNA.
DR RefSeq; XP_001610458.1; XM_001610408.1.
DR AlphaFoldDB; A7AQS1; -.
DR STRING; 5865.A7AQS1; -.
DR EnsemblProtists; EDO06890; EDO06890; BBOV_IV005290.
DR GeneID; 5478692; -.
DR KEGG; bbo:BBOV_IV005290; -.
DR VEuPathDB; PiroplasmaDB:BBOV_IV005290; -.
DR eggNOG; KOG1474; Eukaryota.
DR InParanoid; A7AQS1; -.
DR Proteomes; UP000002173; Unassembled WGS sequence.
DR CDD; cd04369; Bromodomain; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR PANTHER; PTHR45926:SF6; HOMEOTIC PROTEIN FEMALE STERILE-RELATED; 1.
DR PANTHER; PTHR45926; OSJNBA0053K19.4 PROTEIN; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00297; BROMO; 1.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
PE 4: Predicted;
KW Bromodomain {ECO:0000256|PROSITE-ProRule:PRU00035};
KW Reference proteome {ECO:0000313|Proteomes:UP000002173}.
FT DOMAIN 219..291
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 76..98
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 154..177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 409..437
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 560..596
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 613..643
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 664..685
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 699..724
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 84..98
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 154..169
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 574..596
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 724 AA; 82153 MW; 33262737214679D2 CRC64;
MDGDSNVQEE QPVNVPDVVD ESRPSVDKSD SVLGDSAKTL NYRGELTIDQ GEVERINNLI
LHANFRFVIY VNETAKQPPK KTRLDPSLSL NDSFGSSFES RTRKSLSTLQ SLDSRDDDAL
TVSSYDLSEK RSLRKRKQRV RYYEEFAEDP VDGNYREVKQ EKPQKTQKES LKKAGSIGGY
DQRQVQQLYR AVPVLSRNLP KLPRNTWEYT AYRLLQQLKY LDSDKWFWYP VDPVADGVPT
YSKVIKTPMD FYTIIERLHL RQYPNPFAFQ CDVRQIFFNA FLFYPPDNRI WQAAEHLARA
YEEKLGQTRY LHPDEFRELL STGEDAMRST LLDYNEATFN RKSKMASTSF SSMDDIDLSR
PLEKRRAAQN NRHKHILDQF MYNDDDDDSF NELSSVASAD EYMMPVDSIR ANQRGNKRRG
GNTKSSHGAK KSGVDGYDLS DSESRMRYVG NFIAPETGYV PPPPAPIPPG LQKAGGFERG
LTPAQTRTLD INLSRLAPNQ RKAALELIED DLGILAEVFM NDTSFTFDPN LLSVDKQRRV
FVYINQMAKR NLEDMQAALE RNRRIKPVKP GTSERDNKAT TQSNPSEMFD ASSSSSSEIS
DVASNFLSSD DFFESSDEEH SGAHNGTAKS GVKDTSLPEY TPVDELKPEK VQLTRGIMGD
HADFLDHVES PPANDDGTPG QQGKKTAWME WKGQAIHHGT VAQQNGVKPR SVDEQIAESF
DARI
//
