ID A7AR06_BABBO Unreviewed; 1414 AA.
AC A7AR06;
DT 11-SEP-2007, integrated into UniProtKB/TrEMBL.
DT 11-SEP-2007, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=BBOV_IV006150 {ECO:0000313|EMBL:EDO06975.1};
OS Babesia bovis.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Piroplasmida;
OC Babesiidae; Babesia.
OX NCBI_TaxID=5865 {ECO:0000313|EMBL:EDO06975.1, ECO:0000313|Proteomes:UP000002173};
RN [1] {ECO:0000313|EMBL:EDO06975.1, ECO:0000313|Proteomes:UP000002173}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T2Bo {ECO:0000313|EMBL:EDO06975.1};
RX PubMed=17953480; DOI=10.1371/journal.ppat.0030148;
RA Brayton K.A., Lau A.O.T., Herndon D.R., Hannick L., Kappmeyer L.S.,
RA Berens S.J., Bidwell S.L., Brown W.C., Crabtree J., Fadrosh D.,
RA Feldblum T., Forberger H.A., Haas B.J., Howell J.M., Khouri H., Koo H.,
RA Mann D.J., Norimine J., Paulsen I.T., Radune D., Ren Q., Smith R.K. Jr.,
RA Suarez C.E., White O., Wortman J.R., Knowles D.P. Jr., McElwain T.F.,
RA Nene V.M.;
RT "Genome sequence of Babesia bovis and comparative analysis of apicomplexan
RT hemoprotozoa.";
RL PLoS Pathog. 3:1401-1413(2007).
RN [2] {ECO:0000313|Proteomes:UP000002173}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=33294524; DOI=10.1016/j.dib.2020.106533;
RA Ueti M.W., Johnson W.C., Kappmeyer L.S., Herndon D.R., Mousel M.R.,
RA Reif K.E., Taus N.S., Ifeonu O.O., Silva J.C., Suarez C.E., Brayton K.A.;
RT "Transcriptome dataset of Babesia bovis life stages within vertebrate and
RT invertebrate hosts.";
RL Data Brief 33:106533-106533(2020).
RN [3] {ECO:0000313|Proteomes:UP000002173}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=33069745;
RA Ueti M.W., Johnson W.C., Kappmeyer L.S., Herndon D.R., Mousel M.R.,
RA Reif K.E., Taus N.S., Ifeonu O.O., Silva J.C., Suarez C.E., Brayton K.A.;
RT "Comparative analysis of gene expression between Babesia bovis blood stages
RT and kinetes allowed by improved genome annotation.";
RL Int. J. Parasitol. 51:123-136(2021).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001127};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17990;
CC Evidence={ECO:0000256|ARBA:ARBA00001127};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00001416};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46609;
CC Evidence={ECO:0000256|ARBA:ARBA00001416};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDO06975.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAXT01000002; EDO06975.1; -; Genomic_DNA.
DR RefSeq; XP_001610543.1; XM_001610493.1.
DR STRING; 5865.A7AR06; -.
DR EnsemblProtists; EDO06975; EDO06975; BBOV_IV006150.
DR GeneID; 5479379; -.
DR KEGG; bbo:BBOV_IV006150; -.
DR VEuPathDB; PiroplasmaDB:BBOV_IV006150; -.
DR eggNOG; KOG1035; Eukaryota.
DR InParanoid; A7AR06; -.
DR Proteomes; UP000002173; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 3.10.110.10; Ubiquitin Conjugating Enzyme; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR006575; RWD_dom.
DR InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR PANTHER; PTHR11042:SF136; EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE 1; 1.
DR PANTHER; PTHR11042; EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF05773; RWD; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF54495; UBC-like; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS50908; RWD; 1.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022527};
KW Reference proteome {ECO:0000313|Proteomes:UP000002173};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022527}.
FT DOMAIN 48..165
FT /note="RWD"
FT /evidence="ECO:0000259|PROSITE:PS50908"
FT DOMAIN 470..767
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 221..244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1414 AA; 161074 MW; DDFF187B5C12DA9C CRC64;
MEDEELTAEL QAQLDEIHAL HYIFFPATVL QRGRIPQHML ADDIFPVEEY ASLLSQLTVR
TSIELNTHSS DCLDAANLVK VGFRVSPYHG DYSRNLEMPQ SFIEVTFPPE YPQNPPGLSI
VMNMALSQTT VQEVVQRIQN VISNTDDGAC VFNATMCLNE MLGDVHAKLY KLWDDTGTAL
AITFSESMRE QVTDSERKPG YGNIDKYTKS GFESPMYSGR PVYSGQQSEK TQSGSMDMNI
TPTGIRSFND TTMVEREMYS SSVDIAGWSL QSLIQAPLWY EGGLKMNEDN TKDNTAYNLR
RQRSYISSEE QLWKPYGRTE TPGNLISQRT WSYDETPEFQ NASIDHSSAH TRLDIDSSNK
PEHNAECQLD PETSMAITRT ITMLSAMTMS SNIERYRQDF ADAITMTQTP FSKFLKARHA
LDQNMYILRT YELPSFCVLK TQRDISTPKE ESEHFKMRRN VIVQQLVATV ASLARLQHNS
LGRYYHCWVE KVQQHEKVKV LMQRAEALTT GTANVVTTEP AEHEALELWM HDMLLKGNNL
DDPGYIEFLL DEAVIRRRLY IQMEHCDGKT LNRVIQTDGL YKNPQLIWTF TRHLLDVLAY
LHSNNAYHQA LSLKNVIVYS NAQGAGVKVC EFGVARLLRQ FCHKDFFCLH NKCKCRDYSK
QLSRELFAYH PLAFGVEPID YEEMENCSDV EAQQEDMFAL GVLLFRMWHP PLEEKQFKEM
FTTVINTQKF PPYFSHSTPN IILKTILRLV SPGRKPTAVE LLSETLVPPV MNSDLYNQYL
RRLQNPSSEE AVGALKFMLK RGWKADVTRL RADVPIKEIV VMAAVIEGLE TFMRKRSVIV
ESPQVLYPVT QNTERNGIVT VLDETNTLLK LPNNIIKAVE ENLKYITNNE YRLYYRCFNV
TQIYTKHGTK IAAMYSCVLP PSKQQMTYTQ LGIKRTKGAM PVPEAKQRQI GIECDVINTA
MESLKSLPLG ENITMVIQLP PLVVVFIALA FSTDIEKAHH IYTNLAIMDV NQFTLSKLLN
DLNVCNDTVD EKLVATMADI LRRRQTLPEA LLQMQAIVTS TTRSFDTHLA DMFKKVEAQL
TIFFPDNLCA CNYRVCNRKD QTNDNTDMLA TSIYLNQEQY LTGMLHLLGI AIMIKDMQPE
NKIYMDFITE SQVASLCEGS IDYPMFAGYI EQPTKKIVVI GGTVINDDGQ QHCYAEYILE
TLCNAVRPRP YDVDSNDNKG IQVVDVVITS CSVKLLPAAM ALANRLIDTG LSCDCRALPL
IHTDHFNDRI KRAGSVKMRV HLQSSGTTTP NVTVNDQGTI SNNEMVTSDS WHDDREWDDT
GDLQPMDTWQ SKLDVTNKKN KGNIPNADYE LINDTKKQTS GTIEYEDDKM FTGISFQVEP
LKDKYGHTRK IDSLPTLVRY LKSLLSRDNK TTNE
//