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Database: UniProt
Entry: A7ARR0_BABBO
LinkDB: A7ARR0_BABBO
Original site: A7ARR0_BABBO 
ID   A7ARR0_BABBO            Unreviewed;      1065 AA.
AC   A7ARR0;
DT   11-SEP-2007, integrated into UniProtKB/TrEMBL.
DT   11-SEP-2007, sequence version 1.
DT   08-MAY-2019, entry version 71.
DE   RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE            EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN   ORFNames=BBOV_IV008750 {ECO:0000313|EMBL:EDO07229.1};
OS   Babesia bovis.
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Piroplasmida;
OC   Babesiidae; Babesia.
OX   NCBI_TaxID=5865 {ECO:0000313|EMBL:EDO07229.1, ECO:0000313|Proteomes:UP000002173};
RN   [1] {ECO:0000313|EMBL:EDO07229.1, ECO:0000313|Proteomes:UP000002173}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=T2Bo {ECO:0000313|EMBL:EDO07229.1,
RC   ECO:0000313|Proteomes:UP000002173};
RX   PubMed=17953480; DOI=10.1371/journal.ppat.0030148;
RA   Brayton K.A., Lau A.O.T., Herndon D.R., Hannick L., Kappmeyer L.S.,
RA   Berens S.J., Bidwell S.L., Brown W.C., Crabtree J., Fadrosh D.,
RA   Feldblum T., Forberger H.A., Haas B.J., Howell J.M., Khouri H.,
RA   Koo H., Mann D.J., Norimine J., Paulsen I.T., Radune D., Ren Q.,
RA   Smith R.K. Jr., Suarez C.E., White O., Wortman J.R., Knowles D.P. Jr.,
RA   McElwain T.F., Nene V.M.;
RT   "Genome sequence of Babesia bovis and comparative analysis of
RT   apicomplexan hemoprotozoa.";
RL   PLoS Pathog. 3:1401-1413(2007).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-
CC         COMP:11130, Rhea:RHEA-COMP:11131, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:61560, ChEBI:CHEBI:83828; EC=2.7.7.7;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU000442}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC       {ECO:0000256|RuleBase:RU000442}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EDO07229.1}.
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DR   EMBL; AAXT01000002; EDO07229.1; -; Genomic_DNA.
DR   RefSeq; XP_001610797.1; XM_001610747.1.
DR   STRING; 5865.XP_001610797.1; -.
DR   EnsemblProtists; EDO07229; EDO07229; BBOV_IV008750.
DR   GeneID; 5479031; -.
DR   KEGG; bbo:BBOV_IV008750; -.
DR   EuPathDB; PiroplasmaDB:BBOV_IV008750; -.
DR   InParanoid; A7ARR0; -.
DR   KO; K02327; -.
DR   Proteomes; UP000002173; Partially assembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR042087; DNA_pol_B_C.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR025687; Znf-C4pol.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   Pfam; PF14260; zf-C4pol; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|RuleBase:RU000442};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002173};
KW   DNA replication {ECO:0000256|RuleBase:RU000442};
KW   DNA-binding {ECO:0000256|RuleBase:RU000442};
KW   DNA-directed DNA polymerase {ECO:0000256|RuleBase:RU000442};
KW   Iron {ECO:0000256|RuleBase:RU000442};
KW   Iron-sulfur {ECO:0000256|RuleBase:RU000442};
KW   Metal-binding {ECO:0000256|RuleBase:RU000442};
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU000442,
KW   ECO:0000313|EMBL:EDO07229.1};
KW   Nucleus {ECO:0000256|RuleBase:RU000442};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002173};
KW   Transferase {ECO:0000256|RuleBase:RU000442,
KW   ECO:0000313|EMBL:EDO07229.1}; Zinc {ECO:0000256|RuleBase:RU000442};
KW   Zinc-finger {ECO:0000256|RuleBase:RU000442}.
FT   DOMAIN       87    439       DNA_pol_B_exo1. {ECO:0000259|Pfam:
FT                                PF03104}.
FT   DOMAIN      504    936       DNA_pol_B. {ECO:0000259|Pfam:PF00136}.
FT   DOMAIN      973   1043       zf-C4pol. {ECO:0000259|Pfam:PF14260}.
SQ   SEQUENCE   1065 AA;  121011 MW;  6B81B2A2C6937161 CRC64;
     MVAETQLQEP VTDTYTLNGI DYGELFRRCC RPTLDTTQLE DIVMFQTDAD YTSHYEKVGD
     EPLPSSNNTN NVSRMVELPI IRLYGVTRES HSVLVNVHNF MSYFYVEKPV NFKKEHIPLL
     IDFFNKHLME LPPFKKTCRY VIDIDIVQIT PLMLYKPNAK CDYLKVITTL PRMVSSLRSF
     IESGISLPVL DGDNSTRIPF PRQVCEANIP YVLRFLLDGE ITGGCWIRLP KGTYSIVADK
     TSHCSIEVSM DYKDLDPMPI EGEWQSIGPI RTLSFDIECV KFTGPGFPNA NNDPVIQIAS
     VLHTHGDSLD SAQKFVFTLD TCDNLHGAHV LSFANEAALL MAWKQFFIAV DPDFLTGYNI
     INFDIPYLIN RANALKLPEF TQLPRITRSK SSVRDIISSN NTMGTFENKE INIEGRILFD
     VYDLVRRDHK LKSYTLNYVS FEFLKQQKED VHHSTMSKLQ LGSAADRRRI ASYCLKDSVL
     PLLLIDKLLL LFNYVEMARV TSTPIKMLIS RGQQIRVTMQ IYRQCKLMGY AVPSVNAAQR
     AANSEASYEG ATVLEPKKGY HRNAIAVLDF QSLYPSIMIA HNLCYSTLVP PADASKYPAE
     DLTTVPGHPG LYFIKAHVRK GMLPLIVERL IEARKKAKEE MKVCTDPMLR SVLDGRQLAL
     KITTNSVYGY TGASTSGFLP CVEVATAITS FGRYMIVDTK EKIESHFTKA NGYDTDASVV
     YGDTDSVMIN FGTKDISRAI ELGVQAAAMI TNQAIKPITL LFEKVYLPLL LLAKKRYAGL
     YYTKADKYDK IDCKGIETVR RDFCLLVQQM MERILHMLLV DLDLNGAIEF VKSRISQLLR
     NEIDISLLVV TKSLGKVDYD ARLPHVELAK KLRQRDPGKA PSVGDRVSYL IVKGTKNQPQ
     FDRAEEPLYV VENNIPVDTQ HYLDAIKSTL MRIFEVIMPN PESLFSGEHT RFVTLTSSSE
     GALSMFMKKV ERCLGCKTVI KVPPFCDHCN LEKRQQVMLQ KLEERRQKEA DYFDLWSQCQ
     RCQGSLHNEV ICDNRDCPIF YKRVRTGKVL TSMEATYQSL HLEYT
//
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