ID A7ARZ6_BABBO Unreviewed; 1117 AA.
AC A7ARZ6;
DT 11-SEP-2007, integrated into UniProtKB/TrEMBL.
DT 11-SEP-2007, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=U box domain containing protein {ECO:0000313|EMBL:EDO07315.1};
GN ORFNames=BBOV_IV009610 {ECO:0000313|EMBL:EDO07315.1};
OS Babesia bovis.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Piroplasmida;
OC Babesiidae; Babesia.
OX NCBI_TaxID=5865 {ECO:0000313|EMBL:EDO07315.1, ECO:0000313|Proteomes:UP000002173};
RN [1] {ECO:0000313|EMBL:EDO07315.1, ECO:0000313|Proteomes:UP000002173}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T2Bo {ECO:0000313|EMBL:EDO07315.1};
RX PubMed=17953480; DOI=10.1371/journal.ppat.0030148;
RA Brayton K.A., Lau A.O.T., Herndon D.R., Hannick L., Kappmeyer L.S.,
RA Berens S.J., Bidwell S.L., Brown W.C., Crabtree J., Fadrosh D.,
RA Feldblum T., Forberger H.A., Haas B.J., Howell J.M., Khouri H., Koo H.,
RA Mann D.J., Norimine J., Paulsen I.T., Radune D., Ren Q., Smith R.K. Jr.,
RA Suarez C.E., White O., Wortman J.R., Knowles D.P. Jr., McElwain T.F.,
RA Nene V.M.;
RT "Genome sequence of Babesia bovis and comparative analysis of apicomplexan
RT hemoprotozoa.";
RL PLoS Pathog. 3:1401-1413(2007).
RN [2] {ECO:0000313|Proteomes:UP000002173}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=33294524; DOI=10.1016/j.dib.2020.106533;
RA Ueti M.W., Johnson W.C., Kappmeyer L.S., Herndon D.R., Mousel M.R.,
RA Reif K.E., Taus N.S., Ifeonu O.O., Silva J.C., Suarez C.E., Brayton K.A.;
RT "Transcriptome dataset of Babesia bovis life stages within vertebrate and
RT invertebrate hosts.";
RL Data Brief 33:106533-106533(2020).
RN [3] {ECO:0000313|Proteomes:UP000002173}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=33069745;
RA Ueti M.W., Johnson W.C., Kappmeyer L.S., Herndon D.R., Mousel M.R.,
RA Reif K.E., Taus N.S., Ifeonu O.O., Silva J.C., Suarez C.E., Brayton K.A.;
RT "Comparative analysis of gene expression between Babesia bovis blood stages
RT and kinetes allowed by improved genome annotation.";
RL Int. J. Parasitol. 51:123-136(2021).
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the ubiquitin conjugation factor E4 family.
CC {ECO:0000256|ARBA:ARBA00007434}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDO07315.1}.
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DR EMBL; AAXT01000002; EDO07315.1; -; Genomic_DNA.
DR RefSeq; XP_001610883.1; XM_001610833.1.
DR AlphaFoldDB; A7ARZ6; -.
DR STRING; 5865.A7ARZ6; -.
DR EnsemblProtists; EDO07315; EDO07315; BBOV_IV009610.
DR GeneID; 5479117; -.
DR KEGG; bbo:BBOV_IV009610; -.
DR VEuPathDB; PiroplasmaDB:BBOV_IV009610; -.
DR eggNOG; KOG2042; Eukaryota.
DR InParanoid; A7ARZ6; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000002173; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0000151; C:ubiquitin ligase complex; IEA:InterPro.
DR GO; GO:0034450; F:ubiquitin-ubiquitin ligase activity; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IEA:InterPro.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR019474; Ub_conjug_fac_E4_core.
DR InterPro; IPR045132; UBE4.
DR InterPro; IPR003613; Ubox_domain.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR13931:SF2; UBIQUITIN CONJUGATION FACTOR E4 B; 1.
DR PANTHER; PTHR13931; UBIQUITINATION FACTOR E4; 1.
DR Pfam; PF04564; U-box; 1.
DR Pfam; PF10408; Ufd2P_core; 1.
DR SMART; SM00504; Ubox; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS51698; U_BOX; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000002173}.
FT DOMAIN 1033..1107
FT /note="U-box"
FT /evidence="ECO:0000259|PROSITE:PS51698"
FT REGION 817..864
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1117 AA; 127829 MW; 5AFC9D8257BFFD8A CRC64;
MCTPVVVDHV VKDVLGVTLK RPERGTSGTT PTGSNEQRFY VGQFYTRITG LSSTEEVTLD
TPAIDDVVRA TVFACILHNR NPLIFLSEAF CRCSHAISNV ESGKNPFKSA AVSTDEKLSN
DQQCDLRQLL TLLDENIVRT SALIINCPAF FDLETLVDKK DLKRPPLDVL NDDVRCNMMI
EVSSVSKNSL FVQKLIDAIW LNDDSGATVE LFRLFTRLEH NATNKVIGEK PLAELNALTS
ITVSNIGAKL FLNWISDFQG IDNKRKTSGV QRDVLSLWGR ILSTQPLNEE AIDAAPNFHT
TPSVHEKALN ARKIHFHGKK NITAIRNSLA SIRQDHEHYI DLLANFLKQV LRKDFNTRKD
LLLIFGKLIG LNTAMRHISR VTHVEQPPLS IDDNFKRRRQ FMQDSTFGTS LNIMWLMLVL
AAGITDRKVD SIDPYFCQIG FYAKHKMSSS DDSYTEDEKS ILKEIDEMRN VVDNMLGFVS
SGNAAMGDEA QLLEALEKHQ FDLKATFNAN FITQIFWSNI HALGMLYLPC IQELLKLTLF
TLQEASSSPD AMNDSVYEVL SHVFTWKCVV QNSKFIEVVW HFLNISLQFF LRCALYTKWE
NTQSEAQKKL EGPSLYIHIV NQYVAGNMGE SEEMTAEFIV LPVEFIDTIL DVIKQVFMMH
YYMDHIKPAD VNLLQFMNFE LLIATCIFIM RAPQMAIKNL TLKCETVSSI VLHMCRTGDL
ANFASSKTAT IHLVDALTNI FIASQKADYN SRVSCRLNII QILTKLFEIE AYRNSFVKQI
SSNKEIFVQF MHLLINDTTF IFEEVVTYLS EIRRRELSGT TEEAHDRPTE SSDNASQNPE
YQNQHRQDNE YEVDPSLQDG NVDANQLRGM NFNDLKRRTR SLVEYGWEIT NLFNILCREF
PTEITNMSVL LPQVASCLGC CLDNLAGESC TRLKVKNMME YQFKPKEWLT NIVNCYLSLY
RSENASDSER FIKAIVSEGR YYKPNTFERA YRIITREMLL PSKDRRDFFN MSQKMCMFAK
ANSTLYESAM EAEIPEEFID PIMNDIMEDP VLLPTSGVIM DRKNIERHLM SESTDPFSRQ
PLAKSDLVPQ VDLKRRIDVF MESISQKRDI GDDFYQN
//
